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1000 Titel
  • Sex-Specific Muscular Maturation Responses Following Prenatal Exposure to Methylation-Related Micronutrients in Pigs
1000 Autor/in
  1. Oster, Michael |
  2. Trakooljul, Nares |
  3. Reyer, Henry |
  4. Zeyner, Annette |
  5. Muráni, Eduard |
  6. Ponsuksili, Siriluck |
  7. Wimmers, Klaus |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-01-18
1000 Erschienen in
1000 Quellenangabe
  • 9(1): 74
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3390/nu9010074 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295118/ |
1000 Ergänzendes Material
  • http://www.mdpi.com/2072-6643/9/1/74#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Supplementation of micronutrients involved in DNA methylation, particularly during pregnancy, is recommended because of its impacts on human health, but further evidence is needed regarding the effects of over-supplementation and differences between sexes. Here, a porcine model was used to assess effects of maternal supplementation with one-carbon-cycle compounds during prenatal and postnatal stages on offspring muscle development. Sows received either a standard diet (CON) or a standard diet supplemented with folate, B6, B12, methionine, choline, and zinc (MET) throughout gestation. Myogenesis-, growth-, and nutrient utilization-related transcript expression was assessed using quantitative PCR. Organismal phenotype and gene expression effects differed significantly between males and females. Male MET-offspring showed increased fetal weight during late pregnancy but decreased live weight postnatally, with compensatory transcriptional responses comprising myogenic key drivers (Pax7, MyoD1, myogenin). In contrast, female weights were unaffected by diet, and mRNA abundances corresponded to a phenotype of cellular reorganization via FABP3, FABP4, SPP1 and Insulin-like Growth Factor-signaling. These findings in an animal model suggest that supplementation during pregnancy with methylation-related micronutrients can promote sex-specific myogenic maturation processes related to organismal growth and muscle metabolism. The usage of maternal dietary supplements should be more carefully considered regarding its ability to promote fetal and postnatal health.
1000 Sacherschließung
lokal maternal diet
lokal pigs
lokal methyl donors
lokal fetal programming
lokal myogenesis
lokal one-carbon cycle
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|http://orcid.org/0000-0001-6470-0434|https://frl.publisso.de/adhoc/creator/WmV5bmVyLCBBbm5ldHRl|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|http://orcid.org/0000-0002-9523-6790
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1000 @id frl:6402413.rdf
1000 Erstellt am 2017-05-11T13:44:52.105+0200
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 22:49:04 CET 2020
1000 Objekt bearb. Thu Nov 22 10:51:51 CET 2018
1000 Vgl. frl:6402413
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402413 |
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