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1000 Titel
  • Genetically regulated hepatic transcripts and pathways orchestrate haematological, biochemical and body composition traits
1000 Autor/in
  1. Ponsuksili, Siriluck |
  2. Trakooljul, Nares |
  3. Hadlich, Frieder |
  4. Haack, Fiete |
  5. Murani, Eduard |
  6. Wimmers, Klaus |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-12-21
1000 Erschienen in
1000 Quellenangabe
  • 6: 39614
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/srep39614 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175187/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/srep39614#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The liver is the central metabolic organ and exhibits fundamental functions in haematological traits. Hepatic expression, haematological, plasma biochemical, and body composition traits were assessed in a porcine model (n = 297) to establish tissue-specific genetic variations that influence the function of immune-metabolism-correlated expression networks. At FDR (false discovery rate) <1%, more than 3,600 transcripts were jointly correlated (r = |0.22–0.48|) with the traits. Functional enrichment analysis demonstrated common links of metabolic and immune traits. To understand how immune and metabolic traits are affected via genetic regulation of gene expression, eQTLs were assessed. 20517 significant (FDR < 5%) eQTLs for 1401 transcripts were identified, among which 443 transcripts were associated with at least one of the examined traits and had cis-eQTL (such as ACO1 (6.52 × 10−7) and SOD1 (6.41 × 10−30). The present study establishes a comprehensive view of hepatic gene activity which links together metabolic and immune traits in a porcine model for medical research.
1000 Fachgruppe
  1. Agrarwissenschaften |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|https://frl.publisso.de/adhoc/creator/SGFkbGljaCwgRnJpZWRlcg==|https://frl.publisso.de/adhoc/creator/SGFhY2ssIEZpZXRl|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|http://orcid.org/0000-0002-9523-6790
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1000 Erstellt am 2017-05-15T12:02:23.150+0200
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1000 Zuletzt bearbeitet Thu Nov 22 10:53:24 CET 2018
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6402427 |
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