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1000 Titel
  • The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition
1000 Autor/in
  1. Aleksandrova, Krasimira |
  2. Bamia, Christina |
  3. Drogan, Dagmar |
  4. Lagiou, Pagona |
  5. Trichopoulou, Antonia |
  6. Jenab, Mazda |
  7. Fedirko, Veronika |
  8. Romieu, Isabelle |
  9. Bueno-de-Mesquita, H Bas |
  10. Pischon, Tobias |
  11. Tsilidis, Kostas |
  12. Overvad, Kim |
  13. Tjønneland, Anne |
  14. Bouton-Ruault, Marie-Christine |
  15. Dossus, Laure |
  16. Racine, Antoine |
  17. Kaaks, Rudolf |
  18. Kühn, Tilman |
  19. Tsironis, Christos |
  20. Papatesta, Eleni-Maria |
  21. Saitakis, George |
  22. Palli, Domenico |
  23. Panico, Salvatore |
  24. Grioni, Sara |
  25. Tumino, Rosario |
  26. Vineis, Paolo |
  27. Peeters, Petra H |
  28. Weiderpass, Elisabete |
  29. Lukic, Marko |
  30. Braaten, Tonje |
  31. Quirós, J. Ramón |
  32. Luján-Barroso, Leila |
  33. Sánchez, María-José |
  34. Chilarque, Maria-Dolores |
  35. Ardanas, Eva |
  36. Dorronsoro, Miren |
  37. Nilsson, Lena Maria |
  38. Sund, Malin |
  39. Wallström, Peter |
  40. Ohlsson, Bodil |
  41. Bradbury, Kathryn E |
  42. Khaw, Kay-Tee |
  43. Wareham, Nick |
  44. Stepien, Magdalena |
  45. Duarte-Salles, Talita |
  46. Assi, Nada |
  47. Murphy, Neil |
  48. Gunter, Marc J. |
  49. Riboli, Elio |
  50. Boeing, Heiner |
  51. Trichopoulos, Dimitrios |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-11-11
1000 Erschienen in
1000 Quellenangabe
  • 102(6): 1498-1508
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3945/ajcn.115.116095 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. OBJECTIVE: We aimed to evaluate the potential mediating roles of inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between coffee intake and the primary form of liver cancer-hepatocellular carcinoma (HCC). DESIGN: We conducted a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition among 125 incident HCC cases matched to 250 controls using an incidence-density sampling procedure. The association of coffee intake with HCC risk was evaluated by using multivariable-adjusted conditional logistic regression that accounted for smoking, alcohol consumption, hepatitis infection, and other established liver cancer risk factors. The mediating effects of 21 biomarkers were evaluated on the basis of percentage changes and associated 95% CIs in the estimated regression coefficients of models with and without adjustment for biomarkers individually and in combination. RESULTS: The multivariable-adjusted RR of having ≥4 cups (600 mL) coffee/d compared with <2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62; P-trend = 0.006). A statistically significant attenuation of the association between coffee intake and HCC risk and thereby suspected mediation was confirmed for the inflammatory biomarker IL-6 and for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and total bilirubin, which-in combination-attenuated the regression coefficients by 72% (95% CI: 7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced the highest change in the regression coefficients: 40%, 56%, and 60%, respectively. CONCLUSION: These data suggest that the inverse association of coffee intake with HCC risk was partly accounted for by biomarkers of inflammation and hepatocellular injury.
1000 Sacherschließung
lokal European Prospective Investigation into Cancer and Nutrition
lokal biomarkers
lokal coffee
lokal liver cancer
lokal mediation
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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