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1000 Titel
  • Molecular and functional heterogeneity of early postnatal porcine satellite cell populations is associated with bioenergetic profile
1000 Autor/in
  1. Miersch, Claudia |
  2. Stange, Katja |
  3. Hering, Silvio |
  4. Kolisek, Martin |
  5. Viergutz, Torsten |
  6. Röntgen, Monika |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-03-27
1000 Erschienen in
1000 Quellenangabe
  • 7: 45052
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1038/srep45052 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366807/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • During postnatal development, hyperplastic and hypertrophic processes of skeletal muscle growth depend on the activation, proliferation, differentiation, and fusion of satellite cells (SC). Therefore, molecular and functional SC heterogeneity is an important component of muscle plasticity and will greatly affect long-term growth performance and muscle health. However, its regulation by cell intrinsic and extrinsic factors is far from clear. In particular, there is only minor information on the early postnatal period which is critical for muscle maturation and the establishment of adult SC pools. Here, we separated two SC subpopulations (P40/50, P50/70) from muscle of 4-day-old piglets. Our results characterize P40/50 as homogeneous population of committed (high expression of Myf5), fast-proliferating muscle progenitors. P50/70 constituted a slow-proliferating phenotype and contains high numbers of differentiated SC progeny. During culture, P50/70 is transformed to a population with lower differentiation potential that contains 40% Pax7-positive cells. A reversible state of low mitochondrial activity that results from active down-regulation of ATP-synthase is associated with the transition of some of the P50/70 cells to this more primitive fate typical for a reserve cell population. We assume that P40/50 and P50/70 subpopulations contribute unequally in the processes of myofiber growth and maintenance of the SC pool.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWllcnNjaCwgQ2xhdWRpYQ==|https://frl.publisso.de/adhoc/creator/U3RhbmdlLCBLYXRqYQ==|https://frl.publisso.de/adhoc/creator/SGVyaW5nLMKgU2lsdmlv|https://frl.publisso.de/adhoc/creator/S29saXNlayzCoE1hcnRpbg==|https://frl.publisso.de/adhoc/creator/Vmllcmd1dHoswqBUb3JzdGVu|https://frl.publisso.de/adhoc/creator/UsO2bnRnZW4sIE1vbmlrYQ==
1000 Förderer
  1. Leibniz Association |
  2. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. Open Access Fund
  2. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402695.rdf
1000 Erstellt am 2017-05-31T15:04:33.283+0200
1000 Erstellt von 25
1000 beschreibt frl:6402695
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon May 28 13:55:08 CEST 2018
1000 Objekt bearb. Mon May 28 13:55:08 CEST 2018
1000 Vgl. frl:6402695
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402695 |
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