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1000 Titel
  • Centromere sequence and dynamics in Dictyostelium discoideum
1000 Autor/in
  1. Heidel, Andrew J. |
  2. Glöckner, Gernot |
1000 Erscheinungsjahr 2009
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-01-29
1000 Erschienen in
1000 Quellenangabe
  • 37(6): 1809-1816
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2009
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1093/nar/gkp017 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665215/ |
1000 Ergänzendes Material
  • https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkp017#43256055 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Centromeres play a pivotal role in the life of a eukaryote cell, perform an essential and conserved function, but this has not led to a standard centromere structure. It remains currently unclear, how the centromeric function is achieved by widely differing structures. Since centromeres are often large and consist mainly of repetitive sequences they have only been analyzed in great detail in a handful of organisms. The genome of Dictyostelium discoideum, a valuable model organism, was described a few years ago but its centromere organization remained largely unclear. Using available sequence information we reconstructed the putative centromere organization in three of the six chromosomes of D. discoideum. They mainly consist of one type of transposons that is confined to centromeric regions. Centromeres are dynamic due to transposon integration, but an optimal centromere size seems to exist in D. discoideum. One centromere probably has expanded recently, whereas another underwent major rearrangements. In addition to insights into the centromere organization and dynamics of a protist eukaryote, this work also provides a starting point for the analysis of the evolution of centromere structures in social amoebas by comparative genomics.
1000 Sacherschließung
lokal dna transposons
lokal dictyostelium
lokal chromosomes
lokal centromere
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGVpZGVsLCBBbmRyZXcgSi4=|http://orcid.org/0000-0002-9061-1061
1000 Label
1000 Förderer
  1. DFG |
1000 Fördernummer
  1. Gl235/1-2
1000 Förderprogramm
  1. -
1000 Dateien
  1. Centromere sequence and dynamics in Dictyostelium discoideum
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer DFG |
    1000 Förderprogramm -
    1000 Fördernummer Gl235/1-2
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402711.rdf
1000 Erstellt am 2017-06-01T09:50:20.198+0200
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1000 Zuletzt bearbeitet Wed Nov 25 12:56:29 CET 2020
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1000 Vgl. frl:6402711
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402711 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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