WeightNameValue
1000 Titel
  • RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
1000 Autor/in
  1. Grauel, M. Katharina |
  2. Maglione, Marta |
  3. Reddy-Alla, Suneel |
  4. Willmes, Claudia G. |
  5. Brockmann, Marisa M. |
  6. Trimbuch, Thorsten |
  7. Rosenmund, Tanja |
  8. Pangalos, Maria |
  9. Vardar, Gülçin |
  10. Stumpf, Alexander |
  11. Rost, Benjamin R. |
  12. Eickholt, Britta J. |
  13. Schmitz, Dietmar |
  14. Sigrist, Stephan J. |
  15. Rosenmund, Christian |
  16. Haucke, Volker |
  17. Walter, Alexander |
1000 Erscheinungsjahr 2016
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-10-11
1000 Erschienen in
1000 Quellenangabe
  • 113(41): 11615–11620
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068320/ |
  • http://dx.doi.org/10.1073/pnas.1605256113 |
1000 Ergänzendes Material
  • http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1605256113/-/DCSupplemental |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca2+ channels and via RIM with other components of the release machinery. Although human RIM-BPs have been implicated in autism spectrum disorders, little is known about the role of mammalian RIM-BPs in synaptic transmission. We investigated RIM-BP2-deficient murine hippocampal neurons in cultures and slices. Short-term facilitation is significantly enhanced in both model systems. Detailed analysis in culture revealed a reduction in initial release probability, which presumably underlies the increased short-term facilitation. Superresolution microscopy revealed an impairment in CaV2.1 clustering at AZs, which likely alters Ca2+ nanodomains at release sites and thereby affects release probability. Additional deletion of RIM-BP1 does not exacerbate the phenotype, indicating that RIM-BP2 is the dominating RIM-BP isoform at these synapses.
1000 Sacherschließung
lokal Neuroscience
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
  3. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/R3JhdWVsLCBNLiBLYXRoYXJpbmE=|https://frl.publisso.de/adhoc/creator/TWFnbGlvbmUsIE1hcnRh|https://frl.publisso.de/adhoc/creator/UmVkZHktQWxsYSwgU3VuZWVs|https://frl.publisso.de/adhoc/creator/V2lsbG1lcywgQ2xhdWRpYSBHLg==|https://frl.publisso.de/adhoc/creator/QnJvY2ttYW5uLCBNYXJpc2EgTS4=|https://frl.publisso.de/adhoc/creator/VHJpbWJ1Y2gsIFRob3JzdGVu|https://frl.publisso.de/adhoc/creator/Um9zZW5tdW5kLCBUYW5qYQ==|https://frl.publisso.de/adhoc/creator/UGFuZ2Fsb3MsIE1hcmlh|https://frl.publisso.de/adhoc/creator/VmFyZGFyLCAgR8O8bMOnaW4=|https://frl.publisso.de/adhoc/creator/U3R1bXBmLCBBbGV4YW5kZXI=|https://frl.publisso.de/adhoc/creator/Um9zdCwgQmVuamFtaW4gUi4=|https://frl.publisso.de/adhoc/creator/RWlja2hvbHQsIEJyaXR0YSBKLg==|https://frl.publisso.de/adhoc/creator/U2NobWl0eiwgRGlldG1hcg==|https://frl.publisso.de/adhoc/creator/U2lncmlzdCwgU3RlcGhhbiBKLg==|https://frl.publisso.de/adhoc/creator/Um9zZW5tdW5kLCBDaHJpc3RpYW4=|http://orcid.org/0000-0003-3119-6993|http://orcid.org/0000-0001-5646-4750
1000 (Academic) Editor
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Emmy-Noether Program |
  3. Studienstiftung des deutschen Volkes PhD Fellowship |
  4. Excellence Cluster Neurocure |
1000 Fördernummer
  1. SFB 958
  2. -
  3. -
  4. Exc257
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SFB 958
  2. 1000 joinedFunding-child
    1000 Förderer Emmy-Noether Program |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Studienstiftung des deutschen Volkes PhD Fellowship |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Excellence Cluster Neurocure |
    1000 Förderprogramm -
    1000 Fördernummer Exc257
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402731.rdf
1000 Erstellt am 2017-06-01T14:13:19.761+0200
1000 Erstellt von 23
1000 beschreibt frl:6402731
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Nov 22 11:02:00 CET 2018
1000 Objekt bearb. Thu Nov 22 11:01:59 CET 2018
1000 Vgl. frl:6402731
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402731 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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