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1000 Titel
  • Deficiency in mTORC1‐controlled C/EBPβ‐mRNA translation improves metabolic health in mice
1000 Autor/in
  1. Zidek, Laura M. |
  2. Ackermann, Tobias |
  3. Hartleben, Götz |
  4. Eichwald, Sabrina |
  5. Kortman, Gertrud |
  6. Kiehntopf, Michael |
  7. Leutz, Achim |
  8. Sonenberg, Nahum |
  9. Wang, Zhao‐Qi |
  10. Müller, Christine |
  11. Calkhoven, Cornelis F |
  12. von Maltzahn, Julia |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-06-25
1000 Erschienen in
1000 Quellenangabe
  • 16(8): 1022-1036
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.15252/embr.201439837 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552494/ |
1000 Ergänzendes Material
  • http://embor.embopress.org/content/16/8/1022.figures-only |
  • http://embor.embopress.org/content/16/8/1022.figures-only#fig-data-supplementary-materials |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptations in response to changes in nutrient supply. Major downstream targets of mTORC1 signalling are the mRNA translation regulators p70 ribosomal protein S6 kinase 1 (S6K1p70) and the 4E‐binding proteins (4E‐BPs). However, little is known about vertebrate mRNAs that are specifically controlled by mTORC1 signalling and are engaged in regulating mTORC1‐associated physiology. Here, we show that translation of the CCAAT/enhancer binding protein beta (C/EBPβ) mRNA into the C/EBPβ‐LIP isoform is suppressed in response to mTORC1 inhibition either through pharmacological treatment or through calorie restriction. Our data indicate that the function of 4E‐BPs is required for suppression of LIP. Intriguingly, mice lacking the cis‐regulatory upstream open reading frame (uORF) in the C/EBPβ‐mRNA, which is required for mTORC1‐stimulated translation into C/EBPβ‐LIP, display an improved metabolic phenotype with features also found under calorie restriction. Thus, our data suggest that translational adjustment of C/EBPβ‐isoform expression is one of the key processes that direct metabolic adaptation in response to changes in mTORC1 activity.
1000 Sacherschließung
lokal C/EBPβ
lokal calorie restriction
lokal metabolism
lokal translation
lokal mTORC1
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/WmlkZWssIExhdXJhIE0u|https://frl.publisso.de/adhoc/creator/QWNrZXJtYW5uLCBUb2JpYXM=|https://frl.publisso.de/adhoc/creator/SGFydGxlYmVuLCBHw7Z0eg==|https://frl.publisso.de/adhoc/creator/RWljaHdhbGQsIFNhYnJpbmE=|https://frl.publisso.de/adhoc/creator/S29ydG1hbiwgR2VydHJ1ZA==|https://frl.publisso.de/adhoc/creator/S2llaG50b3BmLCBNaWNoYWVs|https://frl.publisso.de/adhoc/creator/TGV1dHosIEFjaGlt|https://frl.publisso.de/adhoc/creator/U29uZW5iZXJnLCBOYWh1bQ==|https://frl.publisso.de/adhoc/creator/V2FuZywgWmhhb_KAkFFp|https://frl.publisso.de/adhoc/creator/TcO8bGxlciwgQ2hyaXN0aW5l|https://frl.publisso.de/adhoc/creator/Q2Fsa2hvdmVuLCBDb3JuZWxpcyBG|http://orcid.org/0000-0001-7674-1487
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. CA 283/1-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer CA 283/1-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402767.rdf
1000 Erstellt am 2017-06-02T12:07:10.004+0200
1000 Erstellt von 24
1000 beschreibt frl:6402767
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri Jan 31 01:46:49 CET 2020
1000 Objekt bearb. Mon May 07 12:41:49 CEST 2018
1000 Vgl. frl:6402767
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402767 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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