WeightNameValue
1000 Titel
  • Glycogen Synthase Kinase 3β Interaction Protein Functions as an A-kinase Anchoring Protein
1000 Autor/in
  1. Hundsrucker, Christian |
  2. Skroblin, Philipp |
  3. Christian, Frank |
  4. Zenn, Hans-Michael |
  5. Popara, Viola |
  6. Joshi, Mangesh |
  7. Eichhorst, Jenny |
  8. Wiesner, Burkhard |
  9. Herberg, Friedrich W. |
  10. Reif, Bernd |
  11. Rosenthal, Walter |
  12. Klussmann, Enno |
1000 Erscheinungsjahr 2009
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-12-11
1000 Erschienen in
1000 Quellenangabe
  • 285: 5507-5521
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820779/ |
  • http://doi.org/10.1074/jbc.M109.047944 |
1000 Ergänzendes Material
  • http://www.jbc.org/cgi/content/full/M109.047944/DC1 |
  • http://www.jbc.org/content/285/8/5507/suppl/DC2 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A-kinase anchoring proteins (AKAPs) include a family of scaffolding proteins that target protein kinase A (PKA) and other signaling proteins to cellular compartments and thereby confine the activities of the associated proteins to distinct regions within cells. AKAPs bind PKA directly. The interaction is mediated by the dimerization and docking domain of regulatory subunits of PKA and the PKA-binding domain of AKAPs. Analysis of the interactions between the dimerization and docking domain and various PKA-binding domains yielded a generalized motif allowing the identification of AKAPs. Our bioinformatics and peptide array screening approaches based on this signature motif identified GSKIP (glycogen synthase kinase 3β interaction protein) as an AKAP. GSKIP directly interacts with PKA and GSK3β (glycogen synthase kinase 3β). It is widely expressed and facilitates phosphorylation and thus inactivation of GSK3β by PKA. GSKIP contains the evolutionarily conserved domain of unknown function 727. We show here that this domain of GSKIP and its vertebrate orthologues binds both PKA and GSK3β and thereby provides a mechanism for the integration of PKA and GSK3β signaling pathways.
1000 Sacherschließung
lokal Signal Transduction/Protein Kinases/Serine/Threonine
lokal Protein/Protein-Protein Interactions
lokal Evolution/Protein
lokal Signal Transduction/Adapter Proteins
lokal AKAP
lokal Glycogen Synthase Kinase 3
lokal Phosphorylation/Kinases/Serine-Threonine
lokal Signal Transduction/Cyclic Nucleotides/Cyclic AMP
lokal Signal Transduction/Protein Kinases/Cyclic Nucleotide
lokal Signal Transduction/Protein Kinases
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SHVuZHNydWNrZXIsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/creator/U2tyb2JsaW4sIFBoaWxpcHA=|http://orcid.org/0000-0001-8208-5930|https://frl.publisso.de/adhoc/creator/WmVubiwgSGFucy1NaWNoYWVs|https://frl.publisso.de/adhoc/creator/UG9wYXJhLCBWaW9sYQ==|https://frl.publisso.de/adhoc/creator/Sm9zaGksIE1hbmdlc2g=|https://frl.publisso.de/adhoc/creator/RWljaGhvcnN0LCBKZW5ueQ==|https://frl.publisso.de/adhoc/creator/V2llc25lciwgQnVya2hhcmQ=|https://frl.publisso.de/adhoc/creator/SGVyYmVyZywgRnJpZWRyaWNoIFcu|http://orcid.org/0000-0001-7368-7198|https://frl.publisso.de/adhoc/creator/Um9zZW50aGFsLCBXYWx0ZXI=|https://frl.publisso.de/adhoc/creator/S2x1c3NtYW5uLCBFbm5v
1000 Förderer
  1. genid-5539c4a841ab4ab4abb7702d66568681-0FBAB44D39E9B683C2D4276EFB1849E5 |
1000 Fördernummer
  1. KL1415/4-1
  2. 037189
  3. FKZ 0315097; FKZ 0315516
1000 Förderprogramm
  1. Forschergruppe 806
  2. Project Thera cAMP
  3. GoBio Program
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer genid-5539c4a841ab4ab4abb7702d66568681-0FBAB44D39E9B683C2D4276EFB1849E5 |
    1000 Förderprogramm Forschergruppe 806
    1000 Fördernummer KL1415/4-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403018.rdf
1000 Erstellt am 2017-06-13T11:20:51.824+0200
1000 Erstellt von 25
1000 beschreibt frl:6403018
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Mar 08 12:47:03 CET 2018
1000 Objekt bearb. Thu Mar 08 12:47:03 CET 2018
1000 Vgl. frl:6403018
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403018 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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