1000 Titel
  • Research Resource: Novel Structural Insights Bridge Gaps in Glycoprotein Hormone Receptor Analyses
1000 Autor/in
  1. Kreuchwig, Annika |
  2. Kleinau, Gunnar |
  3. Krause, Gerd |
1000 Erscheinungsjahr 2013
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-08-01
1000 Erschienen in
1000 Quellenangabe
  • 27(8): 1357-1363
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427943/ |
  • https://doi.org/10.1210/me.2013-1115 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The first version of a glycoprotein hormone receptor (GPHR) information resource was designed to link functional with structural GPHR information, in order to support sequence-structure-function analysis of the LH, FSH, and TSH receptors (http://ssfa-gphr.de). However, structural information on a binding- and signaling-sensitive extracellular fragment (∼100 residues), the hinge region, had been lacking. A new FSHR crystal structure of the hormone-bound extracellular domain has recently been solved. The structure comprises the leucine-rich repeat domain and most parts of the hinge region. We have not only integrated the new FSHR/FSH structure and the derived homology models of TSHR/TSH, LHCGR/CG, and LHCGR/LH into our web-based information resource, but have additionally provided novel tools to analyze the advanced structural features, with the common characteristics and distinctions between GPHRs, in a more precise manner. The hinge region with its second hormone-binding site allows us to assign functional data to the new structural features between hormone and receptor, such as binding details of a sulfated tyrosine (conserved throughout the GPHRs) extending into a pocket of the hormone. We have also implemented a protein interface analysis tool that enables the identification and visualization of extracellular contact points between interaction partners. This provides a starting point for comparing the binding patterns of GPHRs. Together with the mutagenesis data stored in the database, this will help to decipher the essential residues for ligand recognition and the molecular mechanisms of signal transduction, extending from the extracellular hormone-binding site toward the intracellular G protein-binding sites.
1000 Sacherschließung
lokal hormone
lokal signal transduction
lokal protein binding
lokal leucine
lokal internet
lokal glycoprotein hormone
lokal thyrotropin receptor
lokal crystal structure
lokal information resources
lokal hormone binding
lokal thyrotropin
lokal mutagenesis
lokal tyrosine
lokal ligands
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S3JldWNod2lnLCBBbm5pa2E=|https://frl.publisso.de/adhoc/creator/S2xlaW5hdSwgR3VubmFy|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBHZXJk
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. KL2334/2-2; KR1273/4-1
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer KL2334/2-2; KR1273/4-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403137.rdf
1000 Erstellt am 2017-06-19T09:31:26.410+0200
1000 Erstellt von 25
1000 beschreibt frl:6403137
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Aug 18 07:58:36 CEST 2022
1000 Objekt bearb. Wed Mar 31 07:17:53 CEST 2021
1000 Vgl. frl:6403137
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403137 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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