1000 Titel
  • Research Resource: Update and Extension of a Glycoprotein Hormone Receptors Web Application
1000 Autor/in
  1. Kreuchwig, Annika |
  2. Kleinau, Gunnar |
  3. Kreuchwig, Franziska |
  4. Worth, Catherine L. |
  5. Krause, Gerd |
1000 Erscheinungsjahr 2011
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2011-04-01
1000 Erschienen in
1000 Quellenangabe
  • 25(4): 707-712
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417262/ |
  • https://doi.org/10.1210/me.2010-0510 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The SSFA-GPHR (Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors) database provides a comprehensive set of mutation data for the glycoprotein hormone receptors (covering the lutropin, the FSH, and the TSH receptors). Moreover, it provides a platform for comparison and investigation of these homologous receptors and helps in understanding protein malfunctions associated with several diseases. Besides extending the data set (> 1100 mutations), the database has been completely redesigned and several novel features and analysis tools have been added to the web site. These tools allow the focused extraction of semiquantitative mutant data from the GPHR subtypes and different experimental approaches. Functional and structural data of the GPHRs are now linked interactively at the web interface, and new tools for data visualization (on three-dimensional protein structures) are provided. The interpretation of functional findings is supported by receptor morphings simulating intramolecular changes during the activation process, which thus help to trace the potential function of each amino acid and provide clues to the local structural environment, including potentially relocated spatial counterpart residues. Furthermore, double and triple mutations are newly included to allow the analysis of their functional effects related to their spatial interrelationship in structures or homology models. A new important feature is the search option and data visualization by interactive and user-defined snake-plots. These new tools allow fast and easy searches for specific functional data and thereby give deeper insights in the mechanisms of hormone binding, signal transduction, and signaling regulation. The web application “Sequence-Structure-Function-Analysis of GPHRs” is accessible on the internet at http://www.ssfa-gphr.de/.
1000 Sacherschließung
lokal hormone binding
lokal datasets
lokal signal transduction
lokal snakes
lokal internet
lokal glycoprotein hormone
lokal thyrotropin receptor
lokal mutation
lokal amino acids
lokal luteinizing hormone
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S3JldWNod2lnLCBBbm5pa2E=|https://frl.publisso.de/adhoc/creator/S2xlaW5hdSwgR3VubmFy|https://frl.publisso.de/adhoc/creator/S3JldWNod2lnLCBGcmFuemlza2E=|https://frl.publisso.de/adhoc/creator/V29ydGgsIENhdGhlcmluZSBMLg==|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBHZXJk
1000 Label
1000 Förderer
  1. Deutscher Akademischer Austausch Dienst |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Kurt Hahn Trust scholarship 2008–2009
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutscher Akademischer Austausch Dienst |
    1000 Förderprogramm Kurt Hahn Trust scholarship 2008–2009
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403139.rdf
1000 Erstellt am 2017-06-19T09:55:24.216+0200
1000 Erstellt von 25
1000 beschreibt frl:6403139
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Aug 18 07:58:30 CEST 2022
1000 Objekt bearb. Wed Mar 31 07:20:57 CEST 2021
1000 Vgl. frl:6403139
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403139 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source