WeightNameValue
1000 Titel
  • Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model
1000 Autor/in
  1. Wirthgen, Elisa |
  2. Kanitz, Ellen |
  3. Tuchscherer, Margret |
  4. Tuchscherer, Armin |
  5. Domanska, Grazyna |
  6. Weitschies, Werner |
  7. Seidlitz, Anne |
  8. Scheuch, Eberhard |
  9. Otten, Winfried |
1000 Erscheinungsjahr 2015
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-12-28
1000 Erschienen in
1000 Quellenangabe
  • 65(2): 147-155
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873483/ |
  • http://dx.doi.org/10.1538/expanim.15-0096 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Abstract: Increased activity of the tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is associated with immunological and neurological disorders, and inhibition of its enzyme activity could be a therapeutic approach for treatment of these disorders. The aim of the present study was to establish a large animal model to study the accumulation of the potential IDO inhibitor 1-methyltryptophan (1-MT) in blood and different organs of domestic pigs (Sus scrofa domestica). Because 1-MT has not been previously evaluated in pigs, the pharmacokinetics of a single subcutaneous 1-MT application was investigated. Based on this kinetic study, a profile for repeated 1-MT applications over a period of five days was simulated and tested. The results show that a single administration of 1-MT increases its concentrations in blood, with the maximum concentration being obtained at 12 h. Repeated daily injections of 1‑MT generated increasing plasma concentrations followed by a steady-state after two days. Twelve hours after the final application, accumulation of 1-MT was observed in the brain and other organs, with a substantial variability among various tissues. The concentrations of 1-MT measured in plasma and tissues were similar to, or even higher, than those of tryptophan. Our data indicate that repeated subcutaneous injections of 1-MT provide a suitable model for accumulation of 1-MT in plasma and tissues of domestic pigs. These findings provide a basis for further research on the immunoregulatory functions of IDO in a large animal model.
1000 Sacherschließung
lokal methyltryptophan
lokal pharmacokinetics
lokal indoleamine 2,3-dioxygenase
lokal tryptophan
lokal pig
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2lydGhnZW4sIEVsaXNh|https://frl.publisso.de/adhoc/creator/S2FuaXR6LCBFbGxlbg==|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIE1hcmdyZXQ=|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIEFybWlu|https://frl.publisso.de/adhoc/creator/RG9tYW5za2EsIEdyYXp5bmE=|https://frl.publisso.de/adhoc/creator/V2VpdHNjaGllcywgV2VybmVy|https://frl.publisso.de/adhoc/creator/U2VpZGxpdHosIEFubmU=|https://frl.publisso.de/adhoc/creator/U2NoZXVjaCwgRWJlcmhhcmQ=|https://frl.publisso.de/adhoc/creator/T3R0ZW4sIFdpbmZyaWVk
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. KA 1266/5- 1; SCHU 853/7-1
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer KA 1266/5- 1; SCHU 853/7-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403167.rdf
1000 Erstellt am 2017-06-19T15:18:45.198+0200
1000 Erstellt von 22
1000 beschreibt frl:6403167
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 15:34:26 CET 2020
1000 Objekt bearb. Tue Feb 19 11:35:55 CET 2019
1000 Vgl. frl:6403167
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403167 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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