WeightNameValue
1000 Titel
  • Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity
1000 Autor/in
  1. Voigt, Anja |
  2. Katterle, Yvonne |
  3. Kahle, Melanie |
  4. Kluge, Reinhart |
  5. Schürmann, Annette |
  6. Joost, Hans-Georg |
  7. Klaus, Susanne |
1000 Erscheinungsjahr 2015
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-11-19
1000 Erschienen in
1000 Quellenangabe
  • 10(6): 57
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653120/ |
  • https://dx.doi.org/10.1007/s12263-015-0507-x |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Induction of skeletal muscle (SM) mitochondrial stress by expression of uncoupling protein 1 (UCP1) in mice results in a healthy metabolic phenotype associated with increased secretion of FGF21 from SM. Here, we investigated whether SM mitochondrial uncoupling can compensate obesity and insulin resistance in the NZO mouse, a polygenic diabesity model. Male NZO mice were crossed with heterozygous UCP1 transgenic (tg) mice (mixed C57BL/6/CBA background) and further backcrossed to obtain F1 and N2 offspring with 50 and 75 % NZO background, respectively. Male F1 and N2 progeny were fed a high-fat diet ad libitum for 20 weeks from weaning. Blood glucose was reduced, and diabetes (severe hyperglycemia >300 mg/dl) was fully prevented in both F1- and N2-tg progeny compared to a diabetes prevalence of 15 % in F1 and 42 % in N2 wild type. In contrast, relative body fat content and plasma insulin were decreased, and glucose tolerance was improved, in F1-tg only. Both F1 and N2-tg showed decreased lean body mass. Accordingly, induction of SM stress response including FGF21 expression and secretion was similar in both F1 and N2-tg mice. In white adipose tissue, expression of FGF21 target genes was enhanced in F1 and N2-tg mice, whereas lipid metabolism genes were induced in F1-tg only. There was no evidence for induction of browning in either UCP1 backcross. We conclude that SM mitochondrial uncoupling induces FGF21 expression and prevents diabetes in mice with a 50-75 % NZO background independent of its effects on adipose tissue.
1000 Sacherschließung
lokal Glucose metabolism
lokal Fibroblast growth factor 21
lokal White adipose tissue
lokal Uncoupling protein 1
lokal Polygenic obesity
lokal Glucose tolerance test
lokal Diabetes
lokal Lipid metabolism
lokal Gene expression
lokal Body composition
lokal Skeletal muscle
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Vm9pZ3QsIEFuamE=|https://frl.publisso.de/adhoc/creator/S2F0dGVybGUsIFl2b25uZQ==|https://frl.publisso.de/adhoc/creator/S2FobGUsIE1lbGFuaWU=|https://frl.publisso.de/adhoc/creator/S2x1Z2UsIFJlaW5oYXJ0|https://frl.publisso.de/adhoc/creator/U2Now7xybWFubiwgQW5uZXR0ZQ==|http://orcid.org/0000-0002-5860-606X|http://orcid.org/0000-0001-8726-185X
1000 Förderer
  1. European Union’s Seventh Framework Program FP7 2007–2013 |
  2. German Ministry of Education and Research |
  3. State of Brandenburg |
1000 Fördernummer
  1. No. 244995
  2. 01GI0922; 01GI0925
  3. -
1000 Förderprogramm
  1. BIOCLAIMS Project
  2. -
  3. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union’s Seventh Framework Program FP7 2007–2013 |
    1000 Förderprogramm BIOCLAIMS Project
    1000 Fördernummer No. 244995
  2. 1000 joinedFunding-child
    1000 Förderer German Ministry of Education and Research |
    1000 Förderprogramm -
    1000 Fördernummer 01GI0922; 01GI0925
  3. 1000 joinedFunding-child
    1000 Förderer State of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403239.rdf
1000 Erstellt am 2017-06-26T15:28:46.519+0200
1000 Erstellt von 22
1000 beschreibt frl:6403239
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Nov 22 13:30:06 CET 2018
1000 Objekt bearb. Thu Nov 22 13:30:06 CET 2018
1000 Vgl. frl:6403239
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403239 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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