WeightNameValue
1000 Titel
  • Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus
1000 Autor/in
  1. Jakob, Burkhard |
  2. Kochlamazashvili, Gaga |
  3. Jäpel, Maria |
  4. Gauhar, Aziz |
  5. Bock, Hans H. |
  6. Maritzen, Tanja |
  7. Haucke, Volker |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-23
1000 Erschienen in
1000 Quellenangabe
  • 114(21): 5533–5538
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448185/ |
  • http://doi.org/10.1073/pnas.1704447114 |
1000 Ergänzendes Material
  • http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1704447114/-/DCSupplemental |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Brain development and function depend on the directed and coordinated migration of neurons from proliferative zones to their final position. The secreted glycoprotein Reelin is an important factor directing neuronal migration. Loss of Reelin function results in the severe developmental disorder lissencephaly and is associated with neurological diseases in humans. Reelin signals via the lipoprotein receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), but the exact mechanism by which these receptors control cellular function is poorly understood. We report that loss of the signaling scaffold intersectin 1 (ITSN1) in mice leads to defective neuronal migration and ablates Reelin stimulation of hippocampal long-term potentiation (LTP). Knockout (KO) mice lacking ITSN1 suffer from dispersion of pyramidal neurons and malformation of the radial glial scaffold, akin to the hippocampal lamination defects observed in VLDLR or ApoER2 mutants. ITSN1 genetically interacts with Reelin receptors, as evidenced by the prominent neuronal migration and radial glial defects in hippocampus and cortex seen in double-KO mice lacking ITSN1 and ApoER2. These defects were similar to, albeit less severe than, those observed in Reelin-deficient or VLDLR/ ApoER2 double-KO mice. Molecularly, ITSN1 associates with the VLDLR and its downstream signaling adaptor Dab1 to facilitate Reelin signaling. Collectively, these data identify ITSN1 as a component of Reelin signaling that acts predominantly by facilitating the VLDLR-Dab1 axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity.
1000 Sacherschließung
lokal multidomain scaffold
lokal endocytosis
lokal synaptic plasticity
lokal Reelin signaling
lokal hippocampus
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SmFrb2IsIEJ1cmtoYXJk|https://frl.publisso.de/adhoc/creator/S29jaGxhbWF6YXNodmlsaSwgR2FnYQ==|https://frl.publisso.de/adhoc/creator/SsOkcGVsLCBNYXJpYQ==|https://frl.publisso.de/adhoc/creator/R2F1aGFyLCBBeml6|https://frl.publisso.de/adhoc/creator/Qm9jaywgSGFucyBILg==|http://orcid.org/0000-0003-4993-0340|http://orcid.org/0000-0003-3119-6993
1000 Label
1000 Förderer
  1. German Research Foundation |
  2. NeuroCure Cluster of Excellence |
  3. German Ministry of Science |
1000 Fördernummer
  1. SFB958/A01
  2. Exc-257
  3. 0316174C
1000 Förderprogramm
  1. -
  2. -
  3. e:bio project
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer SFB958/A01
  2. 1000 joinedFunding-child
    1000 Förderer NeuroCure Cluster of Excellence |
    1000 Förderprogramm -
    1000 Fördernummer Exc-257
  3. 1000 joinedFunding-child
    1000 Förderer German Ministry of Science |
    1000 Förderprogramm e:bio project
    1000 Fördernummer 0316174C
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403243.rdf
1000 Erstellt am 2017-06-27T12:15:12.114+0200
1000 Erstellt von 25
1000 beschreibt frl:6403243
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet 2022-08-18T07:57:27.009+0200
1000 Objekt bearb. Wed Mar 31 07:28:38 CEST 2021
1000 Vgl. frl:6403243
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403243 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source