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1000 Titel
  • Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
1000 Autor/in
  1. Laenoi, Watchara |
  2. Uddin, Muhammad Jasim |
  3. Cinar, Mehmet Ulas |
  4. Grosse-Brinkhaus, Christine |
  5. Tesfaye, Dawit |
  6. Jonas, Elisabeth |
  7. Scholz, Armin M. |
  8. Tholen, Ernst |
  9. Looft, Christian |
  10. Phatsara, Chirawath |
  11. Juengst, Heinz |
  12. Sauerwein, Helga |
  13. Mielenz, Manfred |
  14. Schellander, Karl |
  15. Wimmers, Klaus |
1000 Erscheinungsjahr 2011
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2011-03-20
1000 Erschienen in
1000 Quellenangabe
  • 43: 13
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2011
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1186/1297-9686-43-13 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072315/ |
1000 Ergänzendes Material
  • https://gsejournal.biomedcentral.com/articles/10.1186/1297-9686-43-13#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs. METHODS: Three hundred and ten F2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software. RESULTS: Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level. CONCLUSIONS: Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TGFlbm9pLCBXYXRjaGFyYQ==|https://frl.publisso.de/adhoc/creator/VWRkaW4sIE11aGFtbWFkIEphc2lt|https://frl.publisso.de/adhoc/creator/Q2luYXIsIE1laG1ldCBVbGFz|https://frl.publisso.de/adhoc/creator/R3Jvc3NlLUJyaW5raGF1cywgQ2hyaXN0aW5l|https://frl.publisso.de/adhoc/creator/VGVzZmF5ZSwgRGF3aXQ=|https://frl.publisso.de/adhoc/creator/Sm9uYXMsIEVsaXNhYmV0aA==|https://frl.publisso.de/adhoc/creator/U2Nob2x6LCBBcm1pbiBNLg==|https://frl.publisso.de/adhoc/creator/VGhvbGVuLCBFcm5zdA==|https://frl.publisso.de/adhoc/creator/TG9vZnQsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/creator/UGhhdHNhcmEsIENoaXJhd2F0aA==|https://frl.publisso.de/adhoc/creator/SnVlbmdzdCwgSGVpbno=|https://frl.publisso.de/adhoc/creator/U2F1ZXJ3ZWluLCBIZWxnYQ==|https://frl.publisso.de/adhoc/creator/TWllbGVueiwgTWFuZnJlZA==|https://frl.publisso.de/adhoc/creator/U2NoZWxsYW5kZXIsIEthcmw=|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. German Federal Ministry of Education and Research (BMBF) |
  2. cooperative project 'FUGATO-plus' (sub-project GENE-FL) |
1000 Fördernummer
  1. -
  2. FK20315135C
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer cooperative project 'FUGATO-plus' (sub-project GENE-FL) |
    1000 Förderprogramm -
    1000 Fördernummer FK20315135C
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403432.rdf
1000 Erstellt am 2017-07-11T08:08:41.506+0200
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon Jun 18 12:24:44 CEST 2018
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