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WeightNameValue
1000 Titel
  • Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice
1000 Autor/in
  1. Brenmoehl, J. |
  2. Ohde, D. |
  3. Walz, Christina |
  4. Tuchscherer, Armin |
  5. Albrecht, Elke |
  6. Hoeflich, Andreas |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-09-30
1000 Erschienen in
1000 Quellenangabe
  • 187(2): 361 - 373
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1007/s00360-016-1036-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253162/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • For the assessment of genetic or conditional factors of fat cell browning, novel and polygenic animal models are required. Therefore, the long-term selected polygenic mouse line DUhTP originally established in Dummerstorf for high treadmill performance is used. DUhTP mice are characterized by increased fat accumulation in the sedentary condition and elevated fat mobilization during mild voluntary physical activity. In the present study, the phenotype of fat cell browning of subcutaneous fat and a potential effect on oral glucose tolerance, an indicator of metabolic health, were addressed in DUhTP mice. Analysis of peripheral fat pads revealed increased brite (brown-in-white) subcutaneous adipose tissues and in subcutaneous fat from DUhTP mice higher levels of irisin and different markers of fat cell browning like T-box transcription factor (Tbx1), PPARα, and uncoupling protein (UCP1) (P < 0.05) when compared to unselected controls. UCP1 was further increased in subcutaneous fat from DUhTP mice in response to mild exercise (fourfold, P < 0.05). In addition, surface temperature of DUhTP mice was increased when compared to controls indicating a physiological effect of increased UCP1 expression. The present study suggests that DUhTP mice exhibit different markers of mitochondrial biogenesis and fat browning without external stimuli. At an age of 43 days, sedentary DUhTP mice have improved metabolic health as judged from lower levels of blood glucose after an oral glucose tolerance test. Consequently, the non-inbred mouse model DUhTP represents a novel model for the identification of fat cell browning mechanisms in white adipose tissues.
1000 Sacherschließung
lokal Irisin
lokal Browning
lokal Uncoupling protein
lokal Selection
lokal Subcutaneous fat
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QnJlbm1vZWhsLCBKLg==|https://frl.publisso.de/adhoc/creator/T2hkZSwgRC4=|https://frl.publisso.de/adhoc/creator/V2FseiwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIEFybWlu|http://orcid.org/0000-0001-5974-1514|http://orcid.org/0000-0003-2018-2836
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
  2. H. Wilhelm Schaumann Stiftung |
  3. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. HO 2003/6-1
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. Open Access fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer HO 2003/6-1
  2. 1000 joinedFunding-child
    1000 Förderer H. Wilhelm Schaumann Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403450.rdf
1000 Erstellt am 2017-07-12T13:19:55.037+0200
1000 Erstellt von 122
1000 beschreibt frl:6403450
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Jan 31 02:02:41 CET 2020
1000 Objekt bearb. Fri May 25 07:22:12 CEST 2018
1000 Vgl. frl:6403450
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403450 |
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