Download
v13p0532.pdf 1,27MB
WeightNameValue
1000 Titel
  • Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle
1000 Autor/in
  1. Schering, Lisa |
  2. Komolka, Katrin |
  3. Kühn, Christa |
  4. Albrecht, Elke |
  5. Maak, Steffen |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-04-10
1000 Erschienen in
1000 Quellenangabe
  • 13(5): 532-544
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.7150/ijbs.18775 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441172/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Thyroid hormone responsive protein (THRSP) is known to be involved in lipogenic processes in rodents. In cattle, THRSP could be a potential molecular marker for intramuscular fat (IMF) deposition since mRNA abundance was frequently found to be increased in skeletal muscle with high IMF content compared to those with low IMF. The aim of this study was to elucidate the background of this differential expression and to evaluate the role of THRSP as candidate for increased IMF content in cattle. By combination of mRNA and protein analyses, we could demonstrate that THRSP is present mainly in nuclei of adipose tissue, in intramuscular fat cells and associated cells, and in cells of the portal triad of liver, whereas muscle cells did not express THRSP. Cell culture analyses revealed furthermore that THRSP is expressed in mature adipocytes rather than in early stages of adipogenesis. Collectively, our data support the putative role of THRSP as transcriptional regulator and demonstrate that an increased expression of THRSP in M. longissimus is a consequence of but not the reason for a higher number of intramuscular adipocytes in cattle with enhanced IMF deposition.
1000 Sacherschließung
lokal intramuscular fat
lokal THRSP
lokal cattle
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/U2NoZXJpbmcsIExpc2E=|https://frl.publisso.de/adhoc/creator/S29tb2xrYSwgS2F0cmlu|https://frl.publisso.de/adhoc/creator/S8O8aG4sIENocmlzdGE=|http://orcid.org/0000-0001-5974-1514|http://orcid.org/0000-0003-2681-1496
1000 Label
1000 Förderer
  1. Leibniz Association |
  2. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. SAW-2013-FBN-3
  2. -
1000 Förderprogramm
  1. Open Access Fund
  2. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer SAW-2013-FBN-3
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403452.rdf
1000 Erstellt am 2017-07-13T10:01:36.493+0200
1000 Erstellt von 25
1000 beschreibt frl:6403452
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 20:33:00 CET 2020
1000 Objekt bearb. Mon May 28 10:00:49 CEST 2018
1000 Vgl. frl:6403452
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403452 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source