Download
MenzelGiuseppe2016.pdf 485,89KB
WeightNameValue
1000 Titel
  • Omentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study
1000 Autor/in
  1. Menzel, Juliane |
  2. di Giuseppe, Romina |
  3. Biemann, Ronald |
  4. Wittenbecher, Clemens |
  5. Aleksandrova, Krasimira |
  6. Pischon, Tobias |
  7. Fritsche, Andreas |
  8. Schulze, Matthias B. |
  9. Böing, Heiner |
  10. Isermann, Berend |
  11. Weikert, Cornelia |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-06-02
1000 Erschienen in
1000 Quellenangabe
  • 251: 415-421
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1016/j.atherosclerosis.2016.06.003 |
1000 Ergänzendes Material
  • http://www.sciencedirect.com/science/article/pii/S002191501630243X?via%3Dihub#appsec1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND AND AIMS: The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke. METHODS: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8.2 ± 1.6 years). Prentice modified Cox regression adjusted for established CVD risk factors was used to estimate associations between omentin-1 and risk of MI and stroke, interactions were tested with cross-product terms. RESULTS: After multivariable adjustment, omentin-1 was not significantly associated with risk of MI (HR per doubling omentin-1:1.17; 95%-CI:0.79-1.72; p = 0.43), but with higher risk of stroke (HR per doubling omentin-1:2.22; 95%-CI:1.52-3.22; p < 0.0001). In subgroup analyses, associations between omentin-1 and stroke risk were generally stronger in lower versus higher CVD risk groups. For example, risk of stroke was stronger in participants without metabolic syndrome (HR per doubling omentin-1:2.58; 95%-CI:1.64-4.07; p < 0.0001) compared to those with metabolic syndrome (HR per doubling omentin-1:1.21; 95%-CI:0.59-2.50; p = 0.60) (p for interaction = 0.05). Similar interactions were observed when participants were classified in low or high risk groups according to waist circumference, triglyceride, hsCRP or adiponectin levels. CONCLUSIONS: Omentin-1 concentrations may be related to increased stroke risk. This association is stronger in metabolically healthy individuals.
1000 Sacherschließung
lokal Risk factor
lokal Intelectin-1
lokal Adipokines
lokal Adiponectin
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0001-7938-4251|https://frl.publisso.de/adhoc/creator/ZGkgR2l1c2VwcGUsIFJvbWluYQ==|https://frl.publisso.de/adhoc/creator/QmllbWFubiwgUm9uYWxk|http://orcid.org/0000-0001-7792-877X|https://frl.publisso.de/adhoc/creator/QWxla3NhbmRyb3ZhLCBLcmFzaW1pcmE=|https://frl.publisso.de/adhoc/creator/UGlzY2hvbiwgVG9iaWFz|https://frl.publisso.de/adhoc/creator/RnJpdHNjaGUsIEFuZHJlYXM=|http://orcid.org/0000-0002-0830-5277|http://d-nb.info/gnd/1111919534|https://frl.publisso.de/adhoc/creator/SXNlcm1hbm4sIEJlcmVuZA==|https://frl.publisso.de/adhoc/creator/V2Vpa2VydCwgQ29ybmVsaWE=
1000 Label
1000 Förderer
  1. Helmholtz Association |
  2. German Federal Ministry of Education and Research (BMBF) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. “Metabolische Dysfunktion und Volkserkrankungen, Teilprojekt: Metabolische Dysfunktion, Entzündungen und kardiovaskuläre Krankheiten sowie metabolische Dysfunktionen und Tumorerkrankungen”
  2. German Center for Diabetes Research (DZD)
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Helmholtz Association |
    1000 Förderprogramm “Metabolische Dysfunktion und Volkserkrankungen, Teilprojekt: Metabolische Dysfunktion, Entzündungen und kardiovaskuläre Krankheiten sowie metabolische Dysfunktionen und Tumorerkrankungen”
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm German Center for Diabetes Research (DZD)
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403852.rdf
1000 Erstellt am 2017-08-14T13:20:17.328+0200
1000 Erstellt von 122
1000 beschreibt frl:6403852
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Mar 04 07:53:23 CET 2021
1000 Objekt bearb. Thu Mar 04 07:53:22 CET 2021
1000 Vgl. frl:6403852
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403852 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source