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1000 Titel
  • Toward improved phosphorus efficiency in monogastrics—interplay of serum, minerals, bone, and immune system after divergent dietary phosphorus supply in swine
1000 Autor/in
  1. Oster, Michael |
  2. Just, Franziska |
  3. Muráni, Eduard |
  4. Ponsuksili, Siriluck |
  5. Büsing, Kirsten |
  6. Wolf, Petra |
  7. Polley, Christian |
  8. Vollmar, Brigitte |
  9. Wimmers, Klaus |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-03-09
1000 Erschienen in
1000 Quellenangabe
  • 310(10): R917-R925
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1152/ajpregu.00215.2015 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896080/ |
1000 Ergänzendes Material
  • http://ajpregu.physiology.org/content/310/10/R917.figures-only#fig-data-additional-files |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Phosphorus (P) is of vital importance for many aspects of metabolism, including bone mineralization, blood buffering, and energy utilization. In order to identify molecular routes affecting intrinsic P utilization, we address processes covering P intake, uptake, metabolism, and excretion. In particular, the interrelation of bone tissue and immune features is of interest to approximate P intake to animal's physiology and health status. German Landrace piglets received different levels of digestible phosphorus: recommended, higher, or lower amounts. At multiple time points, relevant serum parameters were analyzed and radiologic studies on bone characteristics were performed. Peripheral blood mononuclear cells were collected to assess differential gene expression. Dietary differences were reflected by serum phosphorus, calcium, parathyroid hormone, and vitamin D. Bone reorganization was persistently affected as shown by microstructural parameters, cathepsin K levels, and transcripts associated with bone formation. Moreover, blood expression patterns revealed a link to immune response, highlighting bidirectional loops comprising bone formation and immune features, where the receptor-activator of NF-κB ligand/receptor-activator of NF-κB kinase system may play a prominent role. The modulated P supplementation provoked considerable organismal plasticity. Genes found to be differentially expressed due to variable P supply are involved in pathways relevant to P utilization and are potential candidate genes for improved P efficiency.
1000 Sacherschließung
lokal bone characteristics
lokal peripheral blood
lokal diet
lokal mononuclear cell transcriptome
lokal gene expression
lokal phosphorus
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
  3. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/SnVzdCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/QsO8c2luZywgS2lyc3Rlbg==|https://frl.publisso.de/adhoc/creator/V29sZiwgUGV0cmE=|https://frl.publisso.de/adhoc/creator/UG9sbGV5LCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/Vm9sbG1hciwgQnJpZ2l0dGU=|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. Leibniz Science Campus Phosphorus Research Rostock |
  2. European Union |
  3. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. -
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. FP7 EU-project ECO-FCE
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Science Campus Phosphorus Research Rostock |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm FP7 EU-project ECO-FCE
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403866.rdf
1000 Erstellt am 2017-08-14T15:28:11.000+0200
1000 Erstellt von 218
1000 beschreibt frl:6403866
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 27 11:19:07 CEST 2018
1000 Objekt bearb. Wed Jun 27 11:19:06 CEST 2018
1000 Vgl. frl:6403866
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403866 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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