Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

  1. Ambatipudi, Srikant
  2. Cuenin, Cyrille
  3. Hernandez-Vargas, Hector
  4. Ghantous, Akram
  5. Le Calvez-Kelm, Florence
  6. Kaaks, Rudolf
  7. Barrdahl, Myrto
  8. Boeing, Heiner
  9. Aleksandrova, Krasimira
  10. Trichopoulou, Antonia
  11. Lagiou, Pagona
  12. Naska, Androniki
  13. Palli, Domenico
  14. Krogh, Vittorio
  15. Polidoro, Silvia
  16. Tumino, Rosario
  17. Panico, Salvatore
  18. Bueno-de-Mesquita, Bas
  19. Peeters, Petra HM
  20. Quirós, José Ramón
  21. Navarro, Carmen
  22. Ardanaz, Eva
  23. Dorronsoro, Miren
  24. Key, Tim
  25. Vineis, Paolo
  26. Murphy, Neil
  27. Riboli, Elio
  28. Romieu, Isabelle
  29. Herceg, Zdenko

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WeightNameValue
1000 Titel
  • Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study
1000 Autor/in
  1. Ambatipudi, Srikant |
  2. Cuenin, Cyrille |
  3. Hernandez-Vargas, Hector |
  4. Ghantous, Akram |
  5. Le Calvez-Kelm, Florence |
  6. Kaaks, Rudolf |
  7. Barrdahl, Myrto |
  8. Boeing, Heiner |
  9. Aleksandrova, Krasimira |
  10. Trichopoulou, Antonia |
  11. Lagiou, Pagona |
  12. Naska, Androniki |
  13. Palli, Domenico |
  14. Krogh, Vittorio |
  15. Polidoro, Silvia |
  16. Tumino, Rosario |
  17. Panico, Salvatore |
  18. Bueno-de-Mesquita, Bas |
  19. Peeters, Petra HM |
  20. Quirós, José Ramón |
  21. Navarro, Carmen |
  22. Ardanaz, Eva |
  23. Dorronsoro, Miren |
  24. Key, Tim |
  25. Vineis, Paolo |
  26. Murphy, Neil |
  27. Riboli, Elio |
  28. Romieu, Isabelle |
  29. Herceg, Zdenko |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-02-11
1000 Erschienen in
1000 Quellenangabe
  • 8(5): 599-618
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.2217/epi-2016-0001 |
1000 Ergänzendes Material
  • https://www.futuremedicine.com/doi/suppl/10.2217/epi-2016-0001 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • AIM: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. MATERIALS & METHODS: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. RESULTS: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. CONCLUSION: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.
1000 Sacherschließung
lokal tobacco smoking
lokal prospective cohort
lokal epigenetic signature
lokal DNA methylome
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Institut National du Cancer (INCa) |
  2. European Commission (EC) Seventh Framework Programme (FP7) |
  3. Fondation ARC pour la Recherche sur le Cancer |
  4. Hellenic Health Foundation |
  5. Associazione Italiana per la Ricerca sul Cancro-AIRC |
  6. Regional government of Asturias |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
1000 Förderprogramm
  1. 260791
  2. Translational Cancer Research (TRANSCAN); EurocanPlatform: A European Platform for Translational Cancer Research; Marie Curie Actions – People – Co-funding of regional, national and international programmes (COFUND)
  3. -
  4. -
  5. -
  6. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Institut National du Cancer (INCa) |
    1000 Förderprogramm 260791
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Commission (EC) Seventh Framework Programme (FP7) |
    1000 Förderprogramm Translational Cancer Research (TRANSCAN); EurocanPlatform: A European Platform for Translational Cancer Research; Marie Curie Actions – People – Co-funding of regional, national and international programmes (COFUND)
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Fondation ARC pour la Recherche sur le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Hellenic Health Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Associazione Italiana per la Ricerca sul Cancro-AIRC |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Regional government of Asturias |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403954.rdf
1000 Erstellt am 2017-08-17T12:23:11.156+0200
1000 Erstellt von 122
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1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Tue Mar 30 10:42:48 CEST 2021
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