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1000 Titel
  • Risk of Stroke after Herpes Zoster – Evidence from a German Self-Controlled Case-Series Study
1000 Autor/in
  1. Schink, Tania |
  2. Behr, Sigrid |
  3. Thöne, Kathrin |
  4. Bricout, Hélène |
  5. Garbe, Edeltraut |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-11-23
1000 Erschienen in
1000 Quellenangabe
  • 11(11):e0166554
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0166554 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120818/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Herpes zoster (HZ) is caused by reactivation of the latent varicella-zoster virus (VZV). A severe complication of HZ is VZV vasculopathy which can result in ischemic or hemorrhagic stroke. The aims of our study were to assess the risk of stroke after the onset of HZ and to investigate the roles of stroke subtype, HZ location and the time interval between HZ onset and stroke. METHODS: A self-controlled case-series study was performed on a cohort of patients with incident stroke recorded in the German Pharmacoepidemiological Research Database (GePaRD), which covers about 20 million persons throughout Germany. We estimated adjusted incidence rate ratios (IRR) by comparing the rate of stroke in risk periods (i.e., periods following HZ) with the rate of stroke in control periods (i.e., periods without HZ) in the same individuals, controlling for both time-invariant and major potentially time-variant confounders. RESULTS: The cohort included 124,462 stroke patients, of whom 6,035 (5%) had at least one HZ diagnosis identified in GePaRD either as main hospital discharge diagnosis or as HZ treated with antivirals. The risk of stroke was about 1.3 times higher in the risk periods 3 months after HZ onset, than in the control periods (IRR: 1.29; 95% confidence interval: 1.16–1.44). An elevated risk of similar magnitude was observed for ischemic and unspecified stroke, but a 1.5-fold higher risk was observed for hemorrhagic stroke. A slightly stronger effect on the risk of stroke was also observed during the 3 months after HZ ophthalmicus (HZO) onset (1.59; 1.10–2.32). The risk was highest 3 and 4 weeks after HZ onset and decreased thereafter. CONCLUSIONS: Our study corroborates an increased risk of stroke after HZ, which is highest 3 to 4 weeks after HZ onset. The results suggest that the risk is more pronounced after HZO and is numerically higher for hemorrhagic than for ischemic stroke.
1000 Sacherschließung
lokal Myocardial infarcation
lokal Transient ischemic attacks
lokal Stroke
lokal Outpatients
lokal Hemorrhagic stroke
lokal Antivirals
lokal Shingles
lokal Ischemic stroke
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/U2NoaW5rLCBUYW5pYQ==|https://frl.publisso.de/adhoc/creator/QmVociwgU2lncmlk|https://frl.publisso.de/adhoc/creator/VGjDtm5lLCBLYXRocmlu|https://frl.publisso.de/adhoc/creator/QnJpY291dCwgSMOpbMOobmU=|https://frl.publisso.de/adhoc/creator/R2FyYmUsIEVkZWx0cmF1dA==
1000 Förderer
  1. Sanofi Pasteur MSD |
  2. Leibniz-Institut für Präventionsforschung und Epidemiologie (BIPS) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sanofi Pasteur MSD |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz-Institut für Präventionsforschung und Epidemiologie (BIPS) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6403960.rdf
1000 Erstellt am 2017-08-17T14:05:24.831+0200
1000 Erstellt von 122
1000 beschreibt frl:6403960
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon Jun 18 13:18:08 CEST 2018
1000 Objekt bearb. Mon Jun 18 13:18:08 CEST 2018
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6403960 |
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