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1000 Titel
  • Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients
1000 Autor/in
  1. Friemel, Juliane |
  2. Foraita, Ronja |
  3. Günther, Kathrin |
  4. Heibeck, Mathias |
  5. Günther, Frauke |
  6. Pflueger, Maren |
  7. Behrens, Thomas |
  8. Bullerdiek, Jörn |
  9. Nimzyk, Rolf |
  10. Pohlabeln, Hermann |
  11. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-03-11
1000 Erschienen in
1000 Quellenangabe
  • 16: 33
1000 Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12903-016-0185-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788953/ |
1000 Ergänzendes Material
  • https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-016-0185-0#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The survival time of patients with head and neck squamous cell carcinoma (HNSCC) is related to health behavior, such as tobacco smoking and alcohol consumption. Poor oral health (OH), dental care (DC) and the frequent use of mouthwash have been shown to represent independent risk factors for head and neck cancerogenesis, but their impact on the survival of HNSCC patients has not been systematically investigated. METHODS: Two hundred seventy-six incident HNSCC cases recruited for the ARCAGE study were followed through a period of 6–10 years. Interview-based information on wearing of dentures, gum bleeding, teeth brushing, use of floss and dentist visits were grouped into weighted composite scores, i.e. oral health (OH) and dental care (DH). Use of mouthwash was assessed as frequency per day. Also obtained were other types of health behavior, such as smoking, alcohol drinking and diet, appreciated as both confounding and study variables. Endpoints were progression-free survival, overall survival and tumor-specific survival. Prognostic values were estimated using Kaplan-Meier analysis and Cox proportional hazards regression models. RESULTS: A good dental care score, summarizing annual dental visits, daily teeth cleaning and use of floss was associated with longer overall survival time (p = .001). The results of the Cox regression models similarly suggested a higher risk of tumor progression and shortened overall survival in patients with poor dental care, but the results lost their statistical significance after other types of health behavior had been controlled for. Frequent use of mouthwash (≥ 2 times/day) significantly increased the risk of tumor-specific death (HR = 2.26; CI = 1.19–4.32). Alcohol consumption and tobacco smoking were dose-dependently associated with tumor progression and shorter overall survival. CONCLUSION: Frequent mouthwash use of ≥ 2 times/day seems to elevate the risk of tumor-specific death in HNSCC patients. Good dental care scores are associated with longer overall survival.
1000 Freie Schlagwörter
  • Tobacco smoking
  • Head and neck squamous cell carcinoma (HNSCC)
  • Oral health
  • Dental care
  • Alcohol consumption
  • Mouthwash use
1000 Fachgruppe
  1. Biologie |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RnJpZW1lbCwgSnVsaWFuZQ==|https://frl.publisso.de/adhoc/creator/Rm9yYWl0YSwgUm9uamE=|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEthdGhyaW4=|https://frl.publisso.de/adhoc/creator/SGVpYmVjaywgTWF0aGlhcw==|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEZyYXVrZQ==|https://frl.publisso.de/adhoc/creator/UGZsdWVnZXIsIE1hcmVu|https://frl.publisso.de/adhoc/creator/QmVocmVucywgVGhvbWFz|https://frl.publisso.de/adhoc/creator/QnVsbGVyZGllaywgSsO2cm4=|https://frl.publisso.de/adhoc/creator/TmltenlrLCBSb2xm|http://orcid.org/0000-0002-9575-1119|http://orcid.org/0000-0003-3777-570X
1000 Förderer
  1. Leibniz Association
  2. German Research Foundation (DFG)
  3. German Cancer Aid
1000 Fördernummer
  1. -
  2. AH 82/6-1; BU 592/11-1
  3. 110276
1000 Förderprogramm
  1. Open Access fund
  2. -
  3. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404343.rdf
1000 Erstellt am 2017-09-08T14:54:13.734+0200
1000 Erstellt von 218
1000 beschreibt frl:6404343
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jun 14 11:17:47 CEST 2018
1000 Objekt bearb. Thu Jun 14 11:17:47 CEST 2018
1000 Vgl. frl:6404343
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404343 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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