wolters1.pdf 1,54MB
1000 Titel
  • The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children—Analyses based on path models
1000 Autor/in
  1. Wolters, Maike |
  2. Dering, Carmen |
  3. Siani, Alfonso |
  4. Russo, Paola |
  5. Kaprio, Jaakko |
  6. Risé, Patrizia |
  7. Moreno, Luis A |
  8. De Henauw, Stefaan |
  9. Mehlig, Kirsten |
  10. Veidebaum, Toomas |
  11. Molnár, Denés |
  12. Tornaritis, Michael |
  13. Iacoviello, Licia |
  14. Pitsiladis, Yannis |
  15. Galli, Claudio |
  16. Foraita, Ronja |
  17. Börnhorst, Claudia |
1000 Mitwirkende/r
  1. I. Family Consortium |
  2. IDEFICS Consortium |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-07-21
1000 Erschienen in
1000 Quellenangabe
  • 12(7):e0181485
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. METHODS: A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (T<C) and BP z-score as well as the mediating effects of selected key PUFA levels (dihomo-gamma-linolenic acid, DGLA; arachidonic acid, ARA; eicosapentaenoic acid, EPA) or estimated D5D activity (D5D index) and BMI z-score were investigated through path model analyses, adjusting for sex, age, educational level of parents, family history of hypertension, lifestyle factors and blood levels of saturated and monounsaturated fatty acids, triglycerides and low density lipoprotein cholesterol. Whole blood fatty acids were measured by a validated gas chromatographic method and recorded as percentage of weight of all fatty acids detected. RESULTS: Minor allele carriers of the SNP rs174546 had significantly higher DGLA and lower ARA and EPA levels as well as a lower D5D index. Via ARA and BMI z-score, the polymorphism had an indirect lowering effect on systolic BP z-score for each additional T allele (standardized effect estimate -0.057, p = 0.007). For DGLA, EPA and D5D index, the indirect effects of rs174546 on systolic BP were also negative but did not reach significance. DGLA and EPA had an increasing indirect effect on systolic BP via BMI. Results for diastolic BP were in general similar but effect estimates were lower compared to systolic BP. CONCLUSION: Genetic variation in FADS1 influences BP via ARA and BMI indicating a favorable effect of the minor allele in SNP rs174546. Thus, polymorphisms with an impact on the D5D activity may play a role for the BP level mediated through PUFA and BMI. Therefore, health effects of dietary n-6 and n-3 PUFA may vary depending on genetic FADS1 variants.
1000 Sacherschließung
lokal body mass index
lokal childhood obesity
lokal genetic polymorphism
lokal blood pressure
lokal human genetics
lokal hypertension
lokal fatty acids
lokal cardiovascular diseases
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. European Commission |
  2. Leibniz Association |
1000 Fördernummer
  1. 016181; FP7 266044 (KBBE 2010-4)
  2. -
1000 Förderprogramm
  1. Sixth RTD Framework Programme; Seventh RTD Framework Programme
  2. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Sixth RTD Framework Programme; Seventh RTD Framework Programme
    1000 Fördernummer 016181; FP7 266044 (KBBE 2010-4)
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404425.rdf
1000 Erstellt am 2017-09-13T13:07:13.727+0200
1000 Erstellt von 122
1000 beschreibt frl:6404425
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Apr 01 13:21:38 CEST 2021
1000 Objekt bearb. Thu Apr 01 13:21:37 CEST 2021
1000 Vgl. frl:6404425
1000 Oai Id
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1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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