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1000 Titel
  • Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties
1000 Autor/in
  1. Ponsuksili, Siriluck |
  2. Hadlich, Frieder |
  3. Siengdee, Puntita |
  4. Murani, Eduard |
  5. Schwerin, Manfred |
  6. Du, Yang |
  7. Wimmers, Klaus |
1000 Erscheinungsjahr 2013
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-08-05
1000 Erschienen in
1000 Quellenangabe
  • 14: 533
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2013
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/1471-2164-14-533 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750351/ |
1000 Ergänzendes Material
  • https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-533#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Physiological processes aiding the conversion of muscle to meat involve many genes associated with muscle structure and metabolic processes. MicroRNAs regulate networks of genes to orchestrate cellular functions, in turn regulating phenotypes. RESULTS: We applied weighted gene co-expression network analysis to identify co-expression modules that correlated to meat quality phenotypes and were highly enriched for genes involved in glucose metabolism, response to wounding, mitochondrial ribosome, mitochondrion, and extracellular matrix. Negative correlation of miRNA with mRNA and target prediction were used to select transcripts out of the modules of trait-associated mRNAs to further identify those genes that are correlated with post mortem traits. CONCLUSIONS: Porcine muscle co-expression transcript networks that correlated to post mortem traits were identified. The integration of miRNA and mRNA expression analyses, as well as network analysis, enabled us to interpret the differentially-regulated genes from a systems perspective. Linking co-expression networks of transcripts and hierarchically organized pairs of miRNAs and mRNAs to meat properties yields new insight into several biological pathways underlying phenotype differences. These pathways may also be diagnostic for many myopathies, which are accompanied by deficient nutrient and oxygen supply of muscle fibers.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/SGFkbGljaCwgRnJpZWRlcg==|https://frl.publisso.de/adhoc/creator/U2llbmdkZWUsIFB1bnRpdGE=|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|http://orcid.org/0000-0002-5707-513X|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. German Research Foundation (DFG) |
1000 Fördernummer
  1. PO753/6-1; WI1754/14-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer PO753/6-1; WI1754/14-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404549.rdf
1000 Erstellt am 2017-09-21T14:30:03.080+0200
1000 Erstellt von 218
1000 beschreibt frl:6404549
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon May 07 12:27:46 CEST 2018
1000 Objekt bearb. Mon May 07 12:27:46 CEST 2018
1000 Vgl. frl:6404549
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404549 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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