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1000 Titel
  • Risk of acute myocardial infarction with NSAIDs in real world use: Bayesian meta-analysis of individual patient data
1000 Autor/in
  1. Bally, Michèle |
  2. Dendukuri, Nandini |
  3. Rich, Benjamin |
  4. Nadeau, Lyne |
  5. Helin-Salmivaara, Arja |
  6. Garbe, Edeltraut |
  7. Brophy, James M |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-09
1000 Erschienen in
1000 Quellenangabe
  • 357:j1909
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1136/bmj.j1909 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423546/ |
1000 Ergänzendes Material
  • http://www.bmj.com/content/357/bmj.j1909?panels_ajax_tab_tab=jnl_bmj_tab_related_art&panels_ajax_tab_trigger=related#datasupp |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Objective To characterise the determinants, time course, and risks of acute myocardial infarction associated with use of oral non-steroidal anti-inflammatory drugs (NSAIDs). Design Systematic review followed by a one stage bayesian individual patient data meta-analysis. Data sources Studies from Canadian and European healthcare databases. Review methods Eligible studies were sourced from computerised drug prescription or medical databases, conducted in the general or an elderly population, documented acute myocardial infarction as specific outcome, studied selective cyclo-oxygenase-2 inhibitors (including rofecoxib) and traditional NSAIDs, compared risk of acute myocardial infarction in NSAID users with non-users, allowed for time dependent analyses, and minimised effects of confounding and misclassification bias. Exposure and outcomes Drug exposure was modelled as an indicator variable incorporating the specific NSAID, its recency, duration of use, and dose. The outcome measures were the summary adjusted odds ratios of first acute myocardial infarction after study entry for each category of NSAID use at index date (date of acute myocardial infarction for cases, matched date for controls) versus non-use in the preceding year and the posterior probability of acute myocardial infarction. Results A cohort of 446 763 individuals including 61 460 with acute myocardial infarction was acquired. Taking any dose of NSAIDs for one week, one month, or more than a month was associated with an increased risk of myocardial infarction. With use for one to seven days the probability of increased myocardial infarction risk (posterior probability of odds ratio >1.0) was 92% for celecoxib, 97% for ibuprofen, and 99% for diclofenac, naproxen, and rofecoxib. The corresponding odds ratios (95% credible intervals) were 1.24 (0.91 to 1.82) for celecoxib, 1.48 (1.00 to 2.26) for ibuprofen, 1.50 (1.06 to 2.04) for diclofenac, 1.53 (1.07 to 2.33) for naproxen, and 1.58 (1.07 to 2.17) for rofecoxib. Greater risk of myocardial infarction was documented for higher dose of NSAIDs. With use for longer than one month, risks did not appear to exceed those associated with shorter durations. Conclusions All NSAIDs, including naproxen, were found to be associated with an increased risk of acute myocardial infarction. Risk of myocardial infarction with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. Risk was greatest during the first month of NSAID use and with higher doses.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QmFsbHksIE1pY2jDqGxl|https://frl.publisso.de/adhoc/creator/RGVuZHVrdXJpLCBOYW5kaW5p|https://frl.publisso.de/adhoc/creator/UmljaCwgQmVuamFtaW4=|https://frl.publisso.de/adhoc/creator/TmFkZWF1LCBMeW5l|https://frl.publisso.de/adhoc/creator/SGVsaW4tU2FsbWl2YWFyYSwgQXJqYQ==|https://frl.publisso.de/adhoc/creator/R2FyYmUsIEVkZWx0cmF1dA==|https://frl.publisso.de/adhoc/creator/QnJvcGh5LCBKYW1lcyBN
1000 Label
1000 Förderer
  1. McGill University Health Centre Research Institute |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. doctoral research thesis in epidemiology
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer McGill University Health Centre Research Institute |
    1000 Förderprogramm doctoral research thesis in epidemiology
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404580.rdf
1000 Erstellt am 2017-09-22T11:24:23.318+0200
1000 Erstellt von 122
1000 beschreibt frl:6404580
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Apr 08 09:06:17 CEST 2021
1000 Objekt bearb. Thu Apr 08 09:06:17 CEST 2021
1000 Vgl. frl:6404580
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404580 |
1000 Sichtbarkeit Metadaten public
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