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1000 Titel
  • Genetic Deficiency in Neprilysin or Its Pharmacological Inhibition Initiate Excessive Stress-Induced Alcohol Consumption in Mice
1000 Autor/in
  1. Maul, Björn |
  2. Becker, Matthias |
  3. Gembardt, Florian |
  4. Becker, Axel |
  5. Schultheiss, Heinz-Peter |
  6. Siems, Wolf-Eberhard |
  7. Walther, Thomas |
1000 Erscheinungsjahr 2012
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-11-21
1000 Erschienen in
1000 Quellenangabe
  • 7(11): e50187
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2012
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0050187 |
  • http://europepmc.org/articles/PMC3503995 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Both acquired and inherited genetic factors contribute to excessive alcohol consumption and the corresponding development of addiction. Here we show that the genetic deficiency in neprilysin [NEP] did not change the kinetics of alcohol degradation but led to an increase in alcohol intake in mice in a 2-bottle-free-choice paradigm after one single stress stimulus (intruder). A repetition of such stress led to an irreversible elevated alcohol consumption. This phenomenon could be also observed in wild-type mice receiving an orally active NEP inhibitor. We therefore elucidated the stress behavior in NEP-deficient mice. In an Elevated Plus Maze, NEP knockouts crossed more often the area between the arms, implicating a significant stronger stress response. Furthermore, such animals showed a decreased locomotor activity under intense light in a locomotor activity test, identifying such mice to be more responsive in aversive situations than their wild-type controls. Since the reduction in NEP activity itself does not lead to significant signs of an altered alcohol preference in mice but requires an environmental stimulus, our findings build a bridge between stress components and genetic factors in the development of alcoholism. Therefore, targeting NEP activity might be a very attractive approach for the treatment of alcohol abuse in a society with increasing social and financial stress.
1000 Sacherschließung
lokal Alcohol consumption
lokal Psychological stress
lokal Biological locomotion
lokal Animal behavior
lokal Alcoholism
lokal Animal sociality
lokal Mice
lokal Emotions
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWF1bCwgQmrDtnJu|http://orcid.org/0000-0001-9965-6648|https://frl.publisso.de/adhoc/creator/R2VtYmFyZHQsIEZsb3JpYW4=|https://frl.publisso.de/adhoc/creator/QmVja2VyLCBBeGVs|https://frl.publisso.de/adhoc/creator/U2NodWx0aGVpc3MsIEhlaW56LVBldGVy|https://frl.publisso.de/adhoc/creator/U2llbXMsIFdvbGYtRWJlcmhhcmQ=|https://frl.publisso.de/adhoc/creator/V2FsdGhlciwgVGhvbWFz
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. SI 483/3-2; SI 483/3-3; WA1441/18/1-2
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer SI 483/3-2; SI 483/3-3; WA1441/18/1-2
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404646.rdf
1000 Erstellt am 2017-09-25T11:29:16.565+0200
1000 Erstellt von 218
1000 beschreibt frl:6404646
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue Jul 31 12:53:04 CEST 2018
1000 Objekt bearb. Tue Jul 31 12:53:03 CEST 2018
1000 Vgl. frl:6404646
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404646 |
1000 Sichtbarkeit Metadaten public
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