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1000 Titel
  • The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort
1000 Autor/in
  1. Gianfagna, Francesco |
  2. Grippi, Claudio |
  3. Bailey, Mark E S |
  4. Börnhorst, Claudia |
  5. De Henauw, Stefan |
  6. Foraita, Ronja |
  7. Koni, Anna C |
  8. Krogh, Vittorio |
  9. Mårild, Staffan |
  10. Molnár, Dénes |
  11. Moreno, Luis |
  12. Pitsiladis, Yannis |
  13. Russo, Paola |
  14. Siani, Alfonso |
  15. Tornaritis, Michael |
  16. Veidebaum, Toomas |
  17. Iacoviello, Licia |
  18. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-02-24
1000 Erschienen in
1000 Quellenangabe
  • 12(2):e0172698
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0172698 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325300/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172698#sec015 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND AND AIMS: Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene variants and haplotypes and body mass index (BMI) in a large sample of European children. METHODS AND RESULTS: From a large European multi-center study on childhood obesity, 4,528 children (2.0–9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred. Regression models were applied to estimate the associations between SNPs or haplotypes and BMI as well as other anthropometric measures. BMI was associated with all NMU SNPs (p<0.05). Among five haplotypes inferred, the haplotype carrying the minor alleles (CCT, frequency = 22.3%) was the only associated with lower BMI values (beta = -0.16, 95%CI:-0.28,-0.04, p = 0.006; z-score, beta = -0.08, 95%CI:-0.14,-0.01, p = 0.019) and decreased risk of overweight/obesity (OR = 0.81, 95%CI:0.68,0.97, p = 0.020) when compared to the most prevalent haplotype (codominant model). Similar significant associations were also observed using the same variables collected after two years’ time (BMI, beta = -0.25, 95%CI:-0.41,-0.08, p = 0.004; z-score, beta = -0.10, 95%CI:-0.18,-0.03, p = 0.009; overweight/obesity OR = 0.81, 95%CI:0.66,0.99, p = 0.036). The association was age-dependent in girls (interaction between CCT haplotypes and age, p = 0.008), more evident between 7 and 9 years of age. The CCT haplotype was consistently associated with lower levels of fat mass, skinfold thickness, hip and arm circumferences both at T0 and at T1, after adjustment for multiple testing (FDR-adjusted p<0.05). CONCLUSIONS: This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children. Genetic variations within or in linkage with this haplotype should be investigated to identify functional variants responsible for the observed phenotypic variation.
1000 Sacherschließung
lokal haplotypes
lokal children
lokal fats
lokal variant genotypes
lokal Europe
lokal anthropometry
lokal body mass index
lokal obesity
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/R2lhbmZhZ25hLCBGcmFuY2VzY28=|https://frl.publisso.de/adhoc/creator/R3JpcHBpLCBDbGF1ZGlv|https://frl.publisso.de/adhoc/creator/QmFpbGV5LCBNYXJrIEUgUw==|https://frl.publisso.de/adhoc/creator/QsO2cm5ob3JzdCwgQ2xhdWRpYQ==|https://frl.publisso.de/adhoc/creator/RGUgSGVuYXV3LCBTdGVmYW4=|https://frl.publisso.de/adhoc/creator/Rm9yYWl0YSwgUm9uamE=|https://frl.publisso.de/adhoc/creator/S29uaSwgQW5uYSBD|https://frl.publisso.de/adhoc/creator/S3JvZ2gsIFZpdHRvcmlv|https://frl.publisso.de/adhoc/creator/TcOlcmlsZCwgU3RhZmZhbg==|https://frl.publisso.de/adhoc/creator/TW9sbsOhciwgRMOpbmVz|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlz|https://frl.publisso.de/adhoc/creator/UGl0c2lsYWRpcywgWWFubmlz|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/creator/U2lhbmksIEFsZm9uc28=|https://frl.publisso.de/adhoc/creator/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/creator/SWFjb3ZpZWxsbywgTGljaWE=|http://orcid.org/0000-0003-3777-570X
1000 Förderer
  1. European Community |
  2. European Union |
  3. Fondazione Umberto Veronesi |
  4. Italian Ministry of Health |
1000 Fördernummer
  1. 016181 - FOOD
  2. -
  3. -
  4. 167/GR-2011-02351736
1000 Förderprogramm
  1. Sixth RTD Framework Programme
  2. IDEFICS study
  3. 2014 Young Investigator Research Programme award
  4. 2011 Young Investigator Grant
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Sixth RTD Framework Programme
    1000 Fördernummer 016181 - FOOD
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm IDEFICS study
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Fondazione Umberto Veronesi |
    1000 Förderprogramm 2014 Young Investigator Research Programme award
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Italian Ministry of Health |
    1000 Förderprogramm 2011 Young Investigator Grant
    1000 Fördernummer 167/GR-2011-02351736
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404699.rdf
1000 Erstellt am 2017-09-26T13:05:21.822+0200
1000 Erstellt von 122
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 27 11:01:16 CEST 2018
1000 Objekt bearb. Wed Jun 27 11:01:15 CEST 2018
1000 Vgl. frl:6404699
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404699 |
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