Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study

  1. Merritt, Melissa A.
  2. Riboli, Elio
  3. Murphy, Neil
  4. Kadi, Mai
  5. Tjønneland, Anne
  6. Olsen, Anja
  7. Overvad, Kim
  8. Dossus, Laure
  9. Dartois, Laureen
  10. Clavel-Chapelon, Françoise
  11. Fortner, Renée T.
  12. Katzke, Verena A.
  13. Boeing, Heiner ORCID logo
  14. Trichopoulou, Antonia
  15. Lagiou, Pagona
  16. Trichopoulos, Dimitrios
  17. Palli, Domenico
  18. Sieri, Sabina
  19. Tumino, Rosario
  20. Sacerdote, Carlotta
  21. Panico, Salvatore
  22. Bueno-de-Mesquita, H. Bas
  23. Peeters, Petra H.
  24. Lund, Eiliv
  25. Nakamura, Aurelie
  26. Weiderpass, Elisabete
  27. Quirós, J. Ramón
  28. Agudo, Antonio
  29. Molina-Montes, Esther
  30. Larrañaga, Nerea
  31. Dorronsoro, Miren
  32. Cirera, Lluís
  33. Barricarte, Aurelio
  34. Olsson, Åsa
  35. Butt, Salma
  36. Idahl, Annika
  37. Lundin, Eva
  38. Wareham, Nicholas J.
  39. Key, Timothy J.
  40. Brennan, Paul
  41. Ferrari, Pietro
  42. Wark, Petra A.
  43. Norat, Teresa
  44. Cross, Amanda J.
  45. Gunter, Marc J.

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WeightNameValue
1000 Titel
  • Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
1000 Autor/in
  1. Merritt, Melissa A. |
  2. Riboli, Elio |
  3. Murphy, Neil |
  4. Kadi, Mai |
  5. Tjønneland, Anne |
  6. Olsen, Anja |
  7. Overvad, Kim |
  8. Dossus, Laure |
  9. Dartois, Laureen |
  10. Clavel-Chapelon, Françoise |
  11. Fortner, Renée T. |
  12. Katzke, Verena A. |
  13. Boeing, Heiner |
  14. Trichopoulou, Antonia |
  15. Lagiou, Pagona |
  16. Trichopoulos, Dimitrios |
  17. Palli, Domenico |
  18. Sieri, Sabina |
  19. Tumino, Rosario |
  20. Sacerdote, Carlotta |
  21. Panico, Salvatore |
  22. Bueno-de-Mesquita, H. Bas |
  23. Peeters, Petra H. |
  24. Lund, Eiliv |
  25. Nakamura, Aurelie |
  26. Weiderpass, Elisabete |
  27. Quirós, J. Ramón |
  28. Agudo, Antonio |
  29. Molina-Montes, Esther |
  30. Larrañaga, Nerea |
  31. Dorronsoro, Miren |
  32. Cirera, Lluís |
  33. Barricarte, Aurelio |
  34. Olsson, Åsa |
  35. Butt, Salma |
  36. Idahl, Annika |
  37. Lundin, Eva |
  38. Wareham, Nicholas J. |
  39. Key, Timothy J. |
  40. Brennan, Paul |
  41. Ferrari, Pietro |
  42. Wark, Petra A. |
  43. Norat, Teresa |
  44. Cross, Amanda J. |
  45. Gunter, Marc J. |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-10-30
1000 Erschienen in
1000 Quellenangabe
  • 13: 252
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12916-015-0484-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627614/ |
1000 Ergänzendes Material
  • https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0484-3#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. METHODS: The analysis was performed within the European Investigation into Cancer and Nutrition prospective cohort study, which enrolled >500,000 women and men from 1992 to 2000, who were residing in a given town/geographic area in 10 European countries. The current analysis included 322,972 eligible women aged 25–70 years with 99 % complete follow-up for vital status. We assessed reproductive characteristics reported at the study baseline including parity, age at the first birth, breastfeeding, infertility, oral contraceptive use, age at menarche and menopause, total ovulatory years, and history of oophorectomy/hysterectomy. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality were determined using Cox proportional hazards regression models adjusted for menopausal status, body mass index, physical activity, education level, and smoking status/intensity and duration. RESULTS: During a mean follow-up of 12.9 years, 14,383 deaths occurred. The HR (95 % CI) for risk of all-cause mortality was lower in parous versus nulliparous women (0.80; 0.76–0.84), in women who had ever versus never breastfed (0.92; 0.87–0.97), in ever versus never users of oral contraceptives (among non-smokers; 0.90; 0.86–0.95), and in women reporting a later age at menarche (≥15 years versus <12; 0.90; 0.85–0.96; P for trend = 0.038). CONCLUSIONS: Childbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated with better health outcomes. These findings may contribute to the development of improved strategies to promote better long-term health in women.
1000 Sacherschließung
lokal Age at menopause
lokal Oral contraceptives
lokal Mortality
lokal Age at menarche
lokal Parity
lokal Breastfeeding
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. European Commission |
  2. International Agency for Research on Cancer |
  3. Danish Cancer Society (Denmark) |
  4. Ligue Contre le Cancer |
  5. Institut Gustave Roussy |
  6. Mutuelle Générale de l’Education Nationale |
  7. Institut National de la Santé et de la Recherche Médicale (INSERM), France |
  8. German Cancer Aid |
  9. German Cancer Research Center / Deutsches Krebsforschungszentrum (DKFZ) |
  10. Federal Ministry of Education and Research (BMBF) |
  11. Deutsche Krebshilfe |
  12. Federal Ministry of Education and Research (Germany) |
  13. Hellenic Health Foundation (Greece) |
  14. Associazione Italiana per la Ricerca sul Cancro (AIRC), Italy |
  15. National Research Council (Italy) |
  16. Dutch Ministry of Public Health, Welfare and Sports (VWS) |
  17. Netherlands Cancer Registry (NKR) |
  18. - |
  19. - |
  20. Dutch ZON (Zorg Onderzoek Nederland) |
  21. World Cancer Research Fund (WCRF) |
  22. The Netherlands |
  23. European Research Council |
  24. Nordforsk |
  25. Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway) |
  26. - |
  27. - |
  28. ISCIII RETIC |
  29. - |
  30. Regional Government of Andalucía |
  31. Regional Government of Asturias |
  32. Regional Government of Basque Country |
  33. Regional Governments of Murcia |
  34. Regional Government of Navarra |
  35. Swedish Cancer Society |
  36. Swedish Scientific Council |
  37. Regional Government of Skåne and Västerbotten (Sweden) |
  38. Cancer Research, UK |
  39. Medical Research Council, United Kingdom |
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    1000 Förderprogramm EPIC-Norfolk; EPIC-Oxford
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1000 Objektart article
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1000 @id frl:6404703.rdf
1000 Erstellt am 2017-09-26T13:19:40.102+0200
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