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1000 Titel
  • Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
1000 Autor/in
  1. Herrera-Molina, Rodrigo |
  2. Mlinac-Jerkovic, Kristina |
  3. Ilic, Katarina |
  4. Stöber, Franziska |
  5. Vemula, Sampath Kumar |
  6. Sandoval, Mauricio |
  7. Milosevic, Natasa Jovanov |
  8. Simic, Goran |
  9. Smalla, Dr. Karl-Heinz |
  10. Goldschmidt, Jürgen |
  11. Bognar, Svjetlana Kalanj |
  12. Montag, Dirk |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-08-04
1000 Erschienen in
1000 Quellenangabe
  • 7:7273
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/s41598-017-07839-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544750/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-017-07839-9#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca2+ ATPases (PMCAs), an essential regulator of the intracellular Ca2+ concentration ([iCa2+]) and neuronal activity. We show abundant expression and conserved cellular and molecular features of Np in glutamatergic neurons in human hippocampal-cortical pathways as characterized for the rodent brain. In Nptn lox/loxEmx1Cre mice, glutamatergic neuron-selective Np ablation resulted in behavioral deficits indicating hippocampal, striatal, and sensorimotor dysfunction paralleled by highly altered activities in hippocampal CA1 area, sensorimotor cortex layers I-III/IV, and the striatal sensorimotor domain detected by single-photon emission computed tomography. Altered hippocampal and cortical activities correlated with reduction of distinct PMCA paralogs in Nptn lox/loxEmx1Cre mice and increased [iCa2+] in cultured mutant neurons. Human and rodent Np enhanced the post-transcriptional expression of and co-localized with PMCA paralogs in the plasma membrane of transfected cells. Our results indicate Np as essential for PMCA expression in glutamatergic neurons allowing proper [iCa2+] regulation and normal circuit activity. Neuron-type-specific Np ablation empowers the investigation of circuit-coded learning and memory and identification of causal mechanisms leading to cognitive deterioration.
1000 Sacherschließung
lokal Molecular neuroscience
lokal Spatial memory
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGVycmVyYS1Nb2xpbmEsIFJvZHJpZ28=|https://frl.publisso.de/adhoc/creator/TWxpbmFjLUplcmtvdmljLCBLcmlzdGluYQ==|https://frl.publisso.de/adhoc/creator/SWxpYywgS2F0YXJpbmE=|https://frl.publisso.de/adhoc/creator/U3TDtmJlciwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/VmVtdWxhLCBTYW1wYXRoIEt1bWFy|https://frl.publisso.de/adhoc/creator/U2FuZG92YWwsIE1hdXJpY2lv|https://frl.publisso.de/adhoc/creator/TWlsb3NldmljLCBOYXRhc2EgSm92YW5vdg==|https://frl.publisso.de/adhoc/creator/U2ltaWMsIEdvcmFu|https://orcid.org/0000-0002-0269-0311|https://frl.publisso.de/adhoc/creator/R29sZHNjaG1pZHQsIErDvHJnZW4=|https://frl.publisso.de/adhoc/creator/Qm9nbmFyLCBTdmpldGxhbmEgS2FsYW5q|http://orcid.org/0000-0002-4964-1330
1000 Label
1000 Förderer
  1. German Academic Exchange Service (DAAD) |
  2. Deutsche Forschungsgemeinschaft |
  3. Croatian Science Foundation |
  4. Leibniz Association |
1000 Fördernummer
  1. -
  2. SFB854-B08; GRK1167
  3. CSF-IP-2014-09-9730
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Academic Exchange Service (DAAD) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SFB854-B08; GRK1167
  3. 1000 joinedFunding-child
    1000 Förderer Croatian Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer CSF-IP-2014-09-9730
  4. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404788.rdf
1000 Erstellt am 2017-10-02T10:55:25.173+0200
1000 Erstellt von 122
1000 beschreibt frl:6404788
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Apr 08 09:15:32 CEST 2021
1000 Objekt bearb. Thu Apr 08 09:15:31 CEST 2021
1000 Vgl. frl:6404788
1000 Oai Id
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