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1000 Titel
  • Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior
1000 Autor/in
  1. Ponsuksili, Siriluck |
  2. Murani, Eduard |
  3. Trakooljul, Nares |
  4. Krieter, Joachim |
  5. Puppe, Birger |
  6. Schwerin, Manfred |
  7. Zebunke, Manuela |
  8. Wimmers, Klaus |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-11-05
1000 Erschienen in
1000 Quellenangabe
  • 2015(5):16264
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/srep16264 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633681/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/srep16264#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Animal personality and coping styles are basic concepts for evaluating animal welfare. Struggling response of piglets in so-called backtests early in life reflects their coping strategy. Behavioral reactions of piglets in backtests have a moderate heritability, but their genetic basis largely remains unknown. Here, latency, duration and frequency of struggling attempts during one-minute backtests were repeatedly recorded of piglets at days 5, 12, 19, and 26. A genome-wide association study for backtest traits revealed 465 significant SNPs (FDR ≤ 0.05) mostly located in QTL (quantitative trait locus) regions on chromosome 3, 5, 12 and 16. In order to capture genes in these regions, 37 transcripts with significant SNPs were selected for expressionQTL analysis in the hypothalamus. Eight genes (ASGR1, CPAMD8, CTC1, FBXO39, IL19, LOC100511790, RAD51B, UBOX5) had cis- and five (RANGRF, PER1, PDZRN3, SH2D4B, LONP2) had trans-expressionQTL. In particular, for PER1, with known physiological implications for maintenance of circadian rhythms, a role in coping behavior was evidenced by confirmed association in an independent population. For CTC1 a cis-expression QTL and the consistent relationship of gene polymorphism, mRNA expression level and backtest traits promoted its link to coping style. GWAS and eQTL analyses uncovered positional and functional gene candidates for coping behavior.
1000 Sacherschließung
lokal Regulatory networks
lokal Gene expression profiling
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|https://frl.publisso.de/adhoc/creator/S3JpZXRlciwgSm9hY2hpbQ==|https://frl.publisso.de/adhoc/creator/UHVwcGUsIEJpcmdlcg==|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|http://orcid.org/0000-0002-5232-5873|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. Federal Ministry of Education and Research (BMBF) |
  2. The Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. 0315536G
  2. -
1000 Förderprogramm
  1. PHENOMICS project
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm PHENOMICS project
    1000 Fördernummer 0315536G
  2. 1000 joinedFunding-child
    1000 Förderer The Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404797.rdf
1000 Erstellt am 2017-10-04T08:53:18.175+0200
1000 Erstellt von 122
1000 beschreibt frl:6404797
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon May 28 10:12:49 CEST 2018
1000 Objekt bearb. Mon May 28 10:12:49 CEST 2018
1000 Vgl. frl:6404797
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404797 |
1000 Sichtbarkeit Metadaten public
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