Download
pone.0138480.pdf 380,06KB
WeightNameValue
1000 Titel
  • Reproducibility of Retinol Binding Protein 4 and Omentin-1 Measurements over a Four Months Period: A Reliability Study in a Cohort of 207 Apparently Healthy Participants
1000 Autor/in
  1. di Giuseppe, Romina |
  2. Biemann, Ronald |
  3. Arregui, Maria |
  4. Hoffmann, Juliane |
  5. Aleksandrova, Krasimira |
  6. Boeing, Heiner |
  7. Isermann, Berend |
  8. Weikert, Cornelia |
  9. Wittenbecher, Clemens |
  10. Menzel, Juliane |
  11. Schulze, Matthias B. |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-09-24
1000 Erschienen in
1000 Quellenangabe
  • 10(9): e0138480
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0138480 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581620/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The reliability of single time point measurements of the novel adipokines retinol-binding protein 4 and omentin-1 in the blood has not been evaluated in large samples yet. The present study aimed to assess the amount of biological variation of these two adipokines within individuals. The study sample comprised 207 participants (124 women and 83 men) from Potsdam (Germany) and surrounding areas, with an average age of 56.5 years (SD 4.2). Blood samples were collected from each participant twice, approximately four months apart. Using enzyme linked immunosorbent assays, the concentrations of retinol-binding protein 4 and omentin-1 were determined in EDTA plasma. As indicators of reliability, intraclass correlation coefficients (ICCs) were calculated from the repeated biomarker measurements. The ICCs for repeated retinol-binding protein 4 and omentin-1 measurements were 0.77 (95% CI 0.71, 0.82) and 0.83 (95% CI 0.78, 0.87), respectively, indicating for both adipokines excellent reliability. ICCs were stable across strata according to sex, age, BMI, and blood pressure. Thus, for epidemiological studies it seems reasonable to rely on concentrations of retinol-binding protein 4 and omentin-1 in samples from a single time point if repeated measurements are not available.
1000 Sacherschließung
lokal Enzyme assays
lokal Research validity
lokal Biomarkers
lokal Blood pressure
lokal Adipokines
lokal Observational studies
lokal Blood
lokal Blood plasma
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/ZGkgR2l1c2VwcGUsIFJvbWluYQ==|https://frl.publisso.de/adhoc/creator/QmllbWFubiwgUm9uYWxk|https://frl.publisso.de/adhoc/creator/QXJyZWd1aSwgTWFyaWE=|https://frl.publisso.de/adhoc/creator/SG9mZm1hbm4sIEp1bGlhbmU=|https://frl.publisso.de/adhoc/creator/QWxla3NhbmRyb3ZhLCBLcmFzaW1pcmE=|http://orcid.org/0000-0002-3358-1775|https://frl.publisso.de/adhoc/creator/SXNlcm1hbm4sIEJlcmVuZA==|https://frl.publisso.de/adhoc/creator/V2Vpa2VydCwgQ29ybmVsaWE=|http://orcid.org/0000-0001-7792-877X|http://orcid.org/0000-0001-7938-4251|http://orcid.org/0000-0002-0830-5277
1000 Label
1000 Förderer
  1. German Federal Ministry of Education and Research (BMBF) |
  2. German Center for Diabetes Research (DZD) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer German Center for Diabetes Research (DZD) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404890.rdf
1000 Erstellt am 2017-10-09T16:30:18.569+0200
1000 Erstellt von 218
1000 beschreibt frl:6404890
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri Jan 31 02:24:04 CET 2020
1000 Objekt bearb. Tue Sep 04 10:18:53 CEST 2018
1000 Vgl. frl:6404890
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404890 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source