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1000 Titel
  • Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation
1000 Autor/in
  1. Kluth, Oliver |
  2. Matzke, Daniela |
  3. Kamitz, Anne |
  4. Jähnert, Markus |
  5. Vogel, Heike |
  6. Scherneck, Stephan |
  7. Staiger, Harald |
  8. Machicao, Fausto |
  9. Häring, Hans-Ulrich |
  10. Schürmann, Annette |
  11. Schulze, Matthias B. |
  12. Joost, Hans-Georg |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-09-08
1000 Erschienen in
1000 Quellenangabe
  • 11(9): e1005506
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pgen.1005506 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562707/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005506#sec021 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Beta-cell apoptosis and failure to induce beta-cell regeneration are hallmarks of type 2-like diabetes in mouse models. Here we show that islets from obese, diabetes-susceptible New Zealand Obese (NZO) mice, in contrast to diabetes-resistant C57BL/6J (B6)-ob/ob mice, do not proliferate in response to an in-vivo glucose challenge but lose their beta-cells. Genome-wide RNAseq based transcriptomics indicated an induction of 22 cell cycle-associated genes in B6-ob/ob islets that did not respond in NZO islets. Of all genes differentially expressed in islets of the two strains, seven mapped to the diabesity QTL Nob3, and were hypomorphic in either NZO (Lefty1, Apoa2, Pcp4l1, Mndal, Slamf7, Pydc3) or B6 (Ifi202b). Adenoviral overexpression of Lefty1, Apoa2, and Pcp4l1 in primary islet cells increased proliferation, whereas overexpression of Ifi202b suppressed it. We conclude that the identified genes in synergy with obesity and insulin resistance participate in adaptive islet hyperplasia and prevention from severe diabetes in B6-ob/ob mice.
1000 Sacherschließung
lokal Type 2 diabetes
lokal Carbohydrates
lokal Obesity
lokal Diet
lokal Mouse models
lokal Diabetes mellitus
lokal Gene expression
lokal Insulin
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S2x1dGgsIE9saXZlcg==|https://frl.publisso.de/adhoc/creator/TWF0emtlLCBEYW5pZWxh|https://frl.publisso.de/adhoc/creator/S2FtaXR6LCBBbm5l|https://frl.publisso.de/adhoc/creator/SsOkaG5lcnQsIE1hcmt1cw==|https://frl.publisso.de/adhoc/creator/Vm9nZWwsIEhlaWtl|https://frl.publisso.de/adhoc/creator/U2NoZXJuZWNrLCBTdGVwaGFu|https://frl.publisso.de/adhoc/creator/U3RhaWdlciwgSGFyYWxk|https://frl.publisso.de/adhoc/creator/TWFjaGljYW8sIEZhdXN0bw==|https://frl.publisso.de/adhoc/creator/SMOkcmluZywgSGFucy1VbHJpY2g=|https://frl.publisso.de/adhoc/creator/U2Now7xybWFubiwgQW5uZXR0ZQ==|http://orcid.org/0000-0002-0830-5277|http://orcid.org/0000-0002-5860-606X
1000 Förderer
  1. German Research Foundation (DFG) |
  2. German Ministry of Education and Research (BMBF) |
  3. State of Brandenburg |
1000 Fördernummer
  1. GK1208
  2. 01GI0847; 01GI0922; 01GI0925
  3. -
1000 Förderprogramm
  1. -
  2. NEUROTARGET
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer GK1208
  2. 1000 joinedFunding-child
    1000 Förderer German Ministry of Education and Research (BMBF) |
    1000 Förderprogramm NEUROTARGET
    1000 Fördernummer 01GI0847; 01GI0922; 01GI0925
  3. 1000 joinedFunding-child
    1000 Förderer State of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404971.rdf
1000 Erstellt am 2017-10-12T17:02:44.013+0200
1000 Erstellt von 218
1000 beschreibt frl:6404971
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon May 28 09:36:09 CEST 2018
1000 Objekt bearb. Mon May 28 09:36:09 CEST 2018
1000 Vgl. frl:6404971
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404971 |
1000 Sichtbarkeit Metadaten public
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