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WeightNameValue
1000 Titel
  • Temperament Type Specific Metabolite Profiles of the Prefrontal Cortex and Serum in Cattle
1000 Autor/in
  1. Brand, Bodo |
  2. Hadlich, Frieder |
  3. Brandt, Bettina |
  4. Schauer, Nicolas |
  5. Graunke, Katharina L. |
  6. Repsilber, Dirk |
  7. Ponsuksili, Siriluk |
  8. Schwerin, Manfred |
  9. Langbein, Jan |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-04-30
1000 Erschienen in
1000 Quellenangabe
  • 10(4):e0125044
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0125044 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416037/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125044#sec015 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In the past decade the number of studies investigating temperament in farm animals has increased greatly because temperament has been shown not only to affect handling but also reproduction, health and economically important production traits. However, molecular pathways underlying temperament and molecular pathways linking temperament to production traits, health and reproduction have yet to be studied in full detail. Here we report the results of metabolite profiling of the prefrontal cortex and serum of cattle with distinct temperament types that were performed to further explore their molecular divergence in the response to the slaughter procedure and to identify new targets for further research of cattle temperament. By performing an untargeted comprehensive metabolite profiling, 627 and 1097 metabolite features comprising 235 and 328 metabolites could be detected in the prefrontal cortex and serum, respectively. In total, 54 prefrontal cortex and 51 serum metabolite features were indicated to have a high relevance in the classification of temperament types by a sparse partial least square discriminant analysis. A clear discrimination between fearful/neophobic-alert, interested-stressed, subdued/uninterested-calm and outgoing/neophilic-alert temperament types could be observed based on the abundance of the identified relevant prefrontal cortex and serum metabolites. Metabolites with high relevance in the classification of temperament types revealed that the main differences between temperament types in the response to the slaughter procedure were related to the abundance of glycerophospholipids, fatty acyls and sterol lipids. Differences in the abundance of metabolites related to C21 steroid metabolism and oxidative stress indicated that the differences in the metabolite profiles of the four extreme temperament types could be the result of a temperament type specific regulation of molecular pathways that are known to be involved in the stress and fear response.
1000 Sacherschließung
lokal Fear
lokal Oxidative stress
lokal Metabolites
lokal Cattle
lokal Liquid chromatography-mass spectrometry
lokal Metabolic pathways
lokal Lipid metabolism
lokal Prefrontal cortex
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QnJhbmQsIEJvZG8=|https://frl.publisso.de/adhoc/creator/SGFkbGljaCwgRnJpZWRlcg==|https://frl.publisso.de/adhoc/creator/QnJhbmR0LCBCZXR0aW5h|https://frl.publisso.de/adhoc/creator/U2NoYXVlciwgTmljb2xhcw==|https://frl.publisso.de/adhoc/creator/R3JhdW5rZSwgS2F0aGFyaW5hIEwu|https://frl.publisso.de/adhoc/creator/UmVwc2lsYmVyLCBEaXJr|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1aw==|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|http://orcid.org/0000-0002-1170-5431
1000 Label
1000 Förderer
  1. erman Federal Ministry of Education and Research (BMBF) |
  2. Metabolomic Discoveries GmbH |
1000 Fördernummer
  1. 0315535; 0315536A; 0315536G
  2. -
1000 Förderprogramm
  1. “PHENOMICS - a system biological approach of genotype-phenotype-distinction in the context of farm animal performance, health and welfare in cattle and pig”
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer erman Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm “PHENOMICS - a system biological approach of genotype-phenotype-distinction in the context of farm animal performance, health and welfare in cattle and pig”
    1000 Fördernummer 0315535; 0315536A; 0315536G
  2. 1000 joinedFunding-child
    1000 Förderer Metabolomic Discoveries GmbH |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404998.rdf
1000 Erstellt am 2017-10-13T11:54:22.606+0200
1000 Erstellt von 122
1000 beschreibt frl:6404998
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 20:46:08 CET 2020
1000 Objekt bearb. Wed Jun 20 13:29:38 CEST 2018
1000 Vgl. frl:6404998
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404998 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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