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1000 Titel
  • Potential Predictors of Plasma Fibroblast Growth Factor 23 Concentrations: Cross-Sectional Analysis in the EPIC-Germany Study
1000 Autor/in
  1. di Giuseppe, Romina |
  2. Kühn, Tilman |
  3. Hirche, Frank |
  4. Buijsse, Brian |
  5. Dierkes, Jutta |
  6. Fritsche, Andreas |
  7. Kaaks, Rudolf |
  8. Böing, Heiner |
  9. Stangl, Gabriele I. |
  10. Weikert, Cornelia |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-20
1000 Erschienen in
1000 Quellenangabe
  • 10(7): e0133580
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0133580 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508099/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133580#sec018 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. However, what determines higher FGF23 levels is still unclear. Also, little is known about the influence of diet on FGF23. The aim of this study was therefore to identify demographic, clinical and dietary correlates of high FGF23 concentrations in the general population. METHODS: We performed a cross-sectional analysis within a randomly selected subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany comprising 2134 middle-aged men and women. The Human FGF23 (C-Terminal) ELISA kit was used to measure FGF23 in citrate plasma. Dietary data were obtained at baseline via validated food frequency questionnaires including up to 148 food items. RESULTS: Multivariable adjusted logistic regression showed that men had a 66% lower and smokers a 64% higher probability of having higher FGF23 (≥ 90 RU/mL) levels compared, respectively, with women and nonsmokers. Each doubling in parathyroid hormone, creatinine, and C-reactive protein was related to higher FGF23. Among the dietary factors, each doubling in calcium and total energy intake was related, respectively, to a 1.75 and to a 4.41 fold increased probability of having higher FGF23. Finally, each doubling in the intake of iron was related to an 82% lower probability of having higher FGF23 levels. Results did not substantially change after exclusion of participants with lower kidney function. CONCLUSIONS: In middle-aged men and women traditional and non-traditional CVD risk factors were related to higher FGF23 concentrations. These findings may contribute to the understanding of the potential mechanisms linking increased FGF23 to increased CVD risk.
1000 Sacherschließung
lokal Creatinine
lokal Phosphates
lokal Fibroblast growth factor
lokal C-reactive proteins
lokal Diet
lokal Physical activity
lokal Cardiovascular diseases
lokal Blood plasma
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Gesundheitswesen |
  3. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-9587-9745|https://frl.publisso.de/adhoc/creator/S8O8aG4sIFRpbG1hbg==|https://frl.publisso.de/adhoc/creator/SGlyY2hlLCBGcmFuaw==|http://orcid.org/0000-0003-0026-9360|https://frl.publisso.de/adhoc/creator/RGllcmtlcywgSnV0dGE=|https://frl.publisso.de/adhoc/creator/RnJpdHNjaGUsIEFuZHJlYXM=|https://frl.publisso.de/adhoc/creator/S2Fha3MsIFJ1ZG9sZg==|http://d-nb.info/gnd/1111919534|https://frl.publisso.de/adhoc/creator/U3RhbmdsLCBHYWJyaWVsZSBJLg==|https://frl.publisso.de/adhoc/creator/V2Vpa2VydCwgQ29ybmVsaWE=
1000 Förderer
  1. German Heart Research Foundation (DSHF) |
  2. Federal Ministry of Education and Research (BMBF) |
1000 Fördernummer
  1. -
  2. FZK0315668
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Heart Research Foundation (DSHF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer FZK0315668
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405105.rdf
1000 Erstellt am 2017-10-20T15:50:12.293+0200
1000 Erstellt von 218
1000 beschreibt frl:6405105
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 13 13:00:10 CEST 2018
1000 Objekt bearb. Wed Jun 13 13:00:10 CEST 2018
1000 Vgl. frl:6405105
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405105 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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