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1000 Titel
  • Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
1000 Autor/in
  1. Chajès, Véronique |
  2. Biessy, Carine |
  3. Ferrari, Pietro |
  4. Romieu, Isabelle |
  5. Freisling, Heinz |
  6. Huybrechts, Inge |
  7. Scalbert, Augustin |
  8. de Mesquita, Bas Bueno |
  9. Romaguera, Dora |
  10. Gunter, Marc J. |
  11. Vineis, Paolo |
  12. Hansen, Camilla Plambeck |
  13. Jakobsen, Marianne Uhre |
  14. Clavel-Chapelon, Françoise |
  15. Fagherazzi, Guy |
  16. Boutron-Ruault, Marie-Christine |
  17. Katzke, Verana |
  18. Neamat-Allah, Jasmine |
  19. Boeing, Heiner |
  20. Bachlechner, Ursula |
  21. Trichopoulou, Antonia |
  22. Naska, Androniki |
  23. Orfanos, Philippos |
  24. Pala, Valeria |
  25. Masala, Giovanna |
  26. Mattiello, Amalia |
  27. Skeie, Guri |
  28. Weiderpass, Elisabete |
  29. Agudo, Antonio |
  30. Huerta, Jose Maria |
  31. Ardanaz, Eva |
  32. Sánchez, Maria Jose |
  33. Dorronsoro, Miren |
  34. Quirós, Jose Ramon |
  35. Johansson, Ingegerd |
  36. Winkvist, Anna |
  37. Sonested, Emily |
  38. Key, Tim |
  39. Khaw, Kay-Tee |
  40. Wareham, Nicolas J. |
  41. Peeters, Petra H.M. |
  42. Slimani, Nadia |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-02-12
1000 Erschienen in
1000 Quellenangabe
  • 10(2): e0118206
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0118206 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326417/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region. RESULTS: In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend<.0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss (OR = 0.82, 95% CI = 0.66-1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5-year follow-up (OR = 1.08, 95% CI = 0.88-1.33, p = 0.454). No association was found for saturated and cis-monounsaturated fatty acids. CONCLUSIONS: These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially-produced trans fatty acids.
1000 Sacherschließung
lokal Alcohol consumption
lokal Weight loss
lokal Biomarkers
lokal Phospholipids
lokal Fats
lokal Fatty acids
lokal Isomers
lokal Weight gain
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Biologie |
  3. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. European Union |
  2. European Commission |
  3. Ligue contre le Cancer, France |
  4. Société 3M, France |
  5. Mutuelle Générale de l’Education Nationale, France |
  6. Institut National de la Santé et de la Recherche Médicale (INSERM), France |
  7. German Cancer Aid |
  8. German Cancer Research Center |
  9. Federal Ministry of Education and Research, Germany |
  10. Danish Cancer Society |
  11. Health Research Institute Carlos III (Spanish Ministry of Health) |
  12. Spain: participating regional governments and institutions |
  13. Cancer Research UK |
  14. Medical Research Council, UK |
  15. Stroke Association, UK |
  16. British Heart Foundation |
  17. Department of Health, UK |
  18. Food Standards Agency, UK |
  19. Wellcome Trust, UK |
  20. Hellenic Health Foundation, Greece |
  21. Italian Association for Research on Cancer |
  22. National Research Council, Italy |
  23. Associazione Italiana per la Ricerca sul Cancro-AIRC, Italy |
  24. Dutch Ministry of Public Health, Welfare and Sports |
  25. Dutch Ministry of Health |
  26. Dutch Prevention Funds |
  27. LK Research Funds, The Netherlands |
  28. Dutch ZON (Zorg Onderzoek Nederland) |
  29. World Cancer Research Fund (WCRF), The Netherlands |
  30. Swedish Cancer Society |
  31. Swedish Scientific Council |
  32. Regional Government of Skane, Sweden |
  33. Norwegian Cancer Society |
1000 Fördernummer
  1. -
  2. 2005328
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  12. RTICC Rd06/0020/0091; Rd12/0036/0018
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1000 Förderprogramm
  1. EPIC- PANACEA (European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating out of home And obesity) project
  2. Public Health Programme
  3. Public Health and Consumer Protection Directorate 1993–2004; Research Directorate-General 2005
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm EPIC- PANACEA (European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating out of home And obesity) project
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Public Health Programme
    1000 Fördernummer 2005328
  3. 1000 joinedFunding-child
    1000 Förderer Ligue contre le Cancer, France |
    1000 Förderprogramm Public Health and Consumer Protection Directorate 1993–2004; Research Directorate-General 2005
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Société 3M, France |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Mutuelle Générale de l’Education Nationale, France |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Institut National de la Santé et de la Recherche Médicale (INSERM), France |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer German Cancer Aid |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer German Cancer Research Center |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research, Germany |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Danish Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Health Research Institute Carlos III (Spanish Ministry of Health) |
    1000 Förderprogramm -
    1000 Fördernummer -
  12. 1000 joinedFunding-child
    1000 Förderer Spain: participating regional governments and institutions |
    1000 Förderprogramm -
    1000 Fördernummer RTICC Rd06/0020/0091; Rd12/0036/0018
  13. 1000 joinedFunding-child
    1000 Förderer Cancer Research UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  14. 1000 joinedFunding-child
    1000 Förderer Medical Research Council, UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer Stroke Association, UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  16. 1000 joinedFunding-child
    1000 Förderer British Heart Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer Department of Health, UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer Food Standards Agency, UK |
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    1000 Fördernummer -
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    1000 Förderer Wellcome Trust, UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  20. 1000 joinedFunding-child
    1000 Förderer Hellenic Health Foundation, Greece |
    1000 Förderprogramm -
    1000 Fördernummer -
  21. 1000 joinedFunding-child
    1000 Förderer Italian Association for Research on Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  22. 1000 joinedFunding-child
    1000 Förderer National Research Council, Italy |
    1000 Förderprogramm -
    1000 Fördernummer -
  23. 1000 joinedFunding-child
    1000 Förderer Associazione Italiana per la Ricerca sul Cancro-AIRC, Italy |
    1000 Förderprogramm -
    1000 Fördernummer -
  24. 1000 joinedFunding-child
    1000 Förderer Dutch Ministry of Public Health, Welfare and Sports |
    1000 Förderprogramm -
    1000 Fördernummer -
  25. 1000 joinedFunding-child
    1000 Förderer Dutch Ministry of Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  26. 1000 joinedFunding-child
    1000 Förderer Dutch Prevention Funds |
    1000 Förderprogramm -
    1000 Fördernummer -
  27. 1000 joinedFunding-child
    1000 Förderer LK Research Funds, The Netherlands |
    1000 Förderprogramm -
    1000 Fördernummer -
  28. 1000 joinedFunding-child
    1000 Förderer Dutch ZON (Zorg Onderzoek Nederland) |
    1000 Förderprogramm -
    1000 Fördernummer -
  29. 1000 joinedFunding-child
    1000 Förderer World Cancer Research Fund (WCRF), The Netherlands |
    1000 Förderprogramm -
    1000 Fördernummer -
  30. 1000 joinedFunding-child
    1000 Förderer Swedish Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  31. 1000 joinedFunding-child
    1000 Förderer Swedish Scientific Council |
    1000 Förderprogramm -
    1000 Fördernummer -
  32. 1000 joinedFunding-child
    1000 Förderer Regional Government of Skane, Sweden |
    1000 Förderprogramm -
    1000 Fördernummer -
  33. 1000 joinedFunding-child
    1000 Förderer Norwegian Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405281.rdf
1000 Erstellt am 2017-11-06T14:53:06.818+0100
1000 Erstellt von 218
1000 beschreibt frl:6405281
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue Sep 04 10:00:13 CEST 2018
1000 Objekt bearb. Tue Sep 04 10:00:13 CEST 2018
1000 Vgl. frl:6405281
1000 Oai Id
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1000 Sichtbarkeit Metadaten public
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