WeightNameValue
1000 Titel
  • A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk
1000 Autor/in
  1. Aleksandrova, Krasimira |
  2. Chuang, Shu-Chun |
  3. Boeing, Heiner |
  4. Zuo, Hui |
  5. Tell, Grethe S. |
  6. Pischon, Tobias |
  7. Jenab, Mazda |
  8. Bueno-de-Mesquita, Bas |
  9. Vollset, Stein Emil |
  10. Midttun, Øivind |
  11. Ueland, Per Magne |
  12. Fedirko, Veronika |
  13. Johansson, Mattias |
  14. Weiderpass, Elisabete |
  15. Severi, Gianluca |
  16. Racine, Antoine |
  17. Boutron-Ruault, Marie-Christine |
  18. Kaaks, Rudolf |
  19. Kühn, Tilman |
  20. Tjønneland, Anne |
  21. Overvad, Kim |
  22. Quirós, J. Ramón |
  23. Jakszyn, Paula |
  24. Sánchez, María-José |
  25. Dorronsoro, Miren |
  26. Chirlaque, Maria-Dolores |
  27. Ardanaz, Eva |
  28. Khaw, Kay-Tee |
  29. Wareham, Nicholas J. |
  30. Travis, Ruth C. |
  31. Trichopoulou, Antonia |
  32. Lagiou, Pagona |
  33. Trichopoulos, Dimitrios |
  34. Palli, Domenico |
  35. Sieri, Sabina |
  36. Tumino, Rosario |
  37. Panico, Salvatore |
  38. May, Anne M. |
  39. Palmqvist, Richard |
  40. Ljuslinder, Ingrid |
  41. Kong, So Yeon J. |
  42. Freisling, Heinz |
  43. Gunter, Marc J. |
  44. Lu, Yunxia |
  45. Cross, Amanda J. |
  46. Riboli, Elio |
  47. Vineis, Paolo |
1000 Erscheinungsjahr 2015
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-02-24
1000 Erschienen in
1000 Quellenangabe
  • 107(4): djv010
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402364/ |
  • https://doi.org/10.1093/jnci/djv010 |
1000 Ergänzendes Material
  • https://academic.oup.com/jnci/article/107/4/djv010/894565#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. RESULTS: After multivariable adjustment for a priori chosen CRC risk factors, a “U-shaped” association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided Pdifference = .87) and after excluding case patients diagnosed within the first four follow-up years. CONCLUSIONS: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
1000 Sacherschließung
lokal follow-up
lokal plasma drug concentration
lokal colorectal cancer
lokal rectal carcinoma
lokal inflammation
lokal biological markers
lokal colon
lokal immune system
lokal nutrition in cancer
lokal neopterin
lokal oxidative stress
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Gesundheitswesen |
  3. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. Research Council of Norway |
  2. European Prospective Investigation into Cancer and Nutrition (EPIC) cohort |
  3. European Commission |
  4. Danish Cancer Society |
  5. Ligue centre le Cancer |
  6. Institut Gustave Roussy |
  7. Mutuelle Générale de l’Education Nationale |
  8. Institut National de la Santé et de la Recherche Médicale (INSERM) |
  9. Hellenic Health Foundation |
  10. Stavros Niarchos Foundation |
  11. Hellenic Ministry of Health and Social Solidarity |
  12. German Cancer Aid |
  13. Federal Ministry of Education and Research |
  14. Italian Association for Research on Cancer |
  15. National Research Council of Italy |
  16. Dutch Ministry of Public Health, Welfare and Sports (VWS) |
  17. Netherlands Cancer Registry (NKR) |
  18. - |
  19. - |
  20. Dutch ZON (Zorg Onderzoek Nederland) |
  21. - |
  22. - |
  23. Helga – Nordforsk centre of excellence in food, nutrition and health |
  24. Norwegian Extra Foundation for Health and Rehabilitation |
  25. Norwegian Cancer Society |
  26. Spanish Ministry of Health |
  27. Spanish Regional Government of Andalusia |
  28. Spanish Regional Government of Asturias |
  29. Spanish Regional Government of Basque Country |
  30. Spanish Regional Government of Murcia |
  31. Navarra Institute of Oncology |
  32. Catalan Institute of Oncology |
  33. Swedish Cancer Society |
  34. Swedish Scientific Council |
  35. Regional Government of Skane |
  36. Regional Government of Västerbotten |
  37. Cancer Research UK |
  38. Medical Research Council |
  39. National Cancer Institute |
  40. - |
  41. - |
1000 Fördernummer
  1. 204650
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. -
  23. -
  24. -
  25. -
  26. Exp 96/0032; RETICC DR06/0020
  27. -
  28. -
  29. -
  30. N0 6236
  31. -
  32. -
  33. -
  34. -
  35. -
  36. -
  37. -
  38. -
  39. 1RO1CA102460
  40. -
  41. -
1000 Förderprogramm
  1. Hordaland Health Study
  2. -
  3. Europe Against Cancer Program (SANCO)
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. LK Research Funds
  19. Dutch Prevention Funds
  20. -
  21. World Cancer Research Fund (WCRF)
  22. Statistics Netherlands
  23. -
  24. -
  25. -
  26. Health Research Fund (FIS)
  27. -
  28. -
  29. -
  30. -
  31. -
  32. -
  33. -
  34. -
  35. -
  36. -
  37. -
  38. -
  39. -
  40. World Cancer Research Fund International
  41. Wereld Kanker Onderzoek Fonds (WCRF NL)
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Research Council of Norway |
    1000 Förderprogramm Hordaland Health Study
    1000 Fördernummer 204650
  2. 1000 joinedFunding-child
    1000 Förderer European Prospective Investigation into Cancer and Nutrition (EPIC) cohort |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Europe Against Cancer Program (SANCO)
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Danish Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Ligue centre le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Institut Gustave Roussy |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer Mutuelle Générale de l’Education Nationale |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer Institut National de la Santé et de la Recherche Médicale (INSERM) |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer Hellenic Health Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Stavros Niarchos Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Hellenic Ministry of Health and Social Solidarity |
    1000 Förderprogramm -
    1000 Fördernummer -
  12. 1000 joinedFunding-child
    1000 Förderer German Cancer Aid |
    1000 Förderprogramm -
    1000 Fördernummer -
  13. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  14. 1000 joinedFunding-child
    1000 Förderer Italian Association for Research on Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer National Research Council of Italy |
    1000 Förderprogramm -
    1000 Fördernummer -
  16. 1000 joinedFunding-child
    1000 Förderer Dutch Ministry of Public Health, Welfare and Sports (VWS) |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer Netherlands Cancer Registry (NKR) |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm LK Research Funds
    1000 Fördernummer -
  19. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm Dutch Prevention Funds
    1000 Fördernummer -
  20. 1000 joinedFunding-child
    1000 Förderer Dutch ZON (Zorg Onderzoek Nederland) |
    1000 Förderprogramm -
    1000 Fördernummer -
  21. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm World Cancer Research Fund (WCRF)
    1000 Fördernummer -
  22. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm Statistics Netherlands
    1000 Fördernummer -
  23. 1000 joinedFunding-child
    1000 Förderer Helga – Nordforsk centre of excellence in food, nutrition and health |
    1000 Förderprogramm -
    1000 Fördernummer -
  24. 1000 joinedFunding-child
    1000 Förderer Norwegian Extra Foundation for Health and Rehabilitation |
    1000 Förderprogramm -
    1000 Fördernummer -
  25. 1000 joinedFunding-child
    1000 Förderer Norwegian Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  26. 1000 joinedFunding-child
    1000 Förderer Spanish Ministry of Health |
    1000 Förderprogramm Health Research Fund (FIS)
    1000 Fördernummer Exp 96/0032; RETICC DR06/0020
  27. 1000 joinedFunding-child
    1000 Förderer Spanish Regional Government of Andalusia |
    1000 Förderprogramm -
    1000 Fördernummer -
  28. 1000 joinedFunding-child
    1000 Förderer Spanish Regional Government of Asturias |
    1000 Förderprogramm -
    1000 Fördernummer -
  29. 1000 joinedFunding-child
    1000 Förderer Spanish Regional Government of Basque Country |
    1000 Förderprogramm -
    1000 Fördernummer -
  30. 1000 joinedFunding-child
    1000 Förderer Spanish Regional Government of Murcia |
    1000 Förderprogramm -
    1000 Fördernummer N0 6236
  31. 1000 joinedFunding-child
    1000 Förderer Navarra Institute of Oncology |
    1000 Förderprogramm -
    1000 Fördernummer -
  32. 1000 joinedFunding-child
    1000 Förderer Catalan Institute of Oncology |
    1000 Förderprogramm -
    1000 Fördernummer -
  33. 1000 joinedFunding-child
    1000 Förderer Swedish Cancer Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  34. 1000 joinedFunding-child
    1000 Förderer Swedish Scientific Council |
    1000 Förderprogramm -
    1000 Fördernummer -
  35. 1000 joinedFunding-child
    1000 Förderer Regional Government of Skane |
    1000 Förderprogramm -
    1000 Fördernummer -
  36. 1000 joinedFunding-child
    1000 Förderer Regional Government of Västerbotten |
    1000 Förderprogramm -
    1000 Fördernummer -
  37. 1000 joinedFunding-child
    1000 Förderer Cancer Research UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  38. 1000 joinedFunding-child
    1000 Förderer Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer -
  39. 1000 joinedFunding-child
    1000 Förderer National Cancer Institute |
    1000 Förderprogramm -
    1000 Fördernummer 1RO1CA102460
  40. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm World Cancer Research Fund International
    1000 Fördernummer -
  41. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm Wereld Kanker Onderzoek Fonds (WCRF NL)
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405506.rdf
1000 Erstellt am 2017-11-27T16:49:01.173+0100
1000 Erstellt von 25
1000 beschreibt frl:6405506
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue Sep 04 10:15:51 CEST 2018
1000 Objekt bearb. Tue Sep 04 10:15:50 CEST 2018
1000 Vgl. frl:6405506
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405506 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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