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1000 Titel
  • Methodological utility of chemerin as a novel biomarker of immunity and metabolism
1000 Autor/in
  1. Eichelmann, Fabian |
  2. Weikert, Cornelia |
  3. di Giuseppe, Romina |
  4. Biemann, Ronald |
  5. Isermann, Berend |
  6. Böing, Heiner |
  7. Aleksandrova, Krasimira |
  8. Schulze, Matthias B. |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-06-07
1000 Erschienen in
1000 Quellenangabe
  • 6(5): 340-347
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1530/EC-17-0098 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510453/ |
1000 Ergänzendes Material
  • http://www.endocrineconnections.com/content/6/5/340.figures-only |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses. Intra-individual reproducibility of chemerin measurements was assessed by calculating intraclass correlation coefficients (ICCs) and exploration of Bland–Altman plots. Reliability analyses revealed good reproducibility of chemerin measurements (ICC: 0.72 (95%-CI 0.65, 0.78)). Visual inspection of Bland–Altman plots confirmed that the two time point measurements had a high level of agreement. In correlation analyses, chemerin was positively correlated with adiposity measures (body mass index and waist circumference). In addition, independent of adiposity measures, chemerin was correlated with the biomarkers C-reactive protein, fatty acid-binding protein 4 and progranulin (Rho-s ranging from 0.23 to 0.37). In multivariable linear regression analysis, a combination of correlated factors including body mass index, waist circumference, C-reactive protein, progranulin and fatty acid-binding protein-4 explained 28.0% of chemerin concentrations. These findings demonstrate methodological utility of chemerin concentrations in population-based research setting. Human studies are highly warranted in order to provide further insights into the role of chemerin as a biomarker linking immunity and metabolism in relation to chronic disease risk.
1000 Sacherschließung
lokal adipokine
lokal reliability
lokal immune system
lokal chemerin
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RWljaGVsbWFubiwgRmFiaWFu|https://frl.publisso.de/adhoc/creator/V2Vpa2VydCwgQ29ybmVsaWE=|https://frl.publisso.de/adhoc/creator/ZGkgR2l1c2VwcGUsIFJvbWluYQ==|https://frl.publisso.de/adhoc/creator/QmllbWFubiwgUm9uYWxk|https://frl.publisso.de/adhoc/creator/SXNlcm1hbm4sIEJlcmVuZA==|http://d-nb.info/gnd/1111919534|https://frl.publisso.de/adhoc/creator/QWxla3NhbmRyb3ZhLCBLcmFzaW1pcmE=|http://orcid.org/0000-0002-0830-5277
1000 Label
1000 Fördernummer
  1. 01 EA 9401
  2. SOC 95201408 05F02; SOC 98200769 05F02
  3. 70-2488-Ha I
  4. AL 1784/3-1
  5. -
  6. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. internal funding
  5. Open Access Fund
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405687.rdf
1000 Erstellt am 2017-12-04T13:54:00.085+0100
1000 Erstellt von 122
1000 beschreibt frl:6405687
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 16:10:58 CET 2020
1000 Objekt bearb. Fri Jul 27 11:09:51 CEST 2018
1000 Vgl. frl:6405687
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405687 |
1000 Sichtbarkeit Metadaten public
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