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WeightNameValue
1000 Titel
  • Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism
1000 Autor/in
  1. Oster, Michael |
  2. Magowan, Elizabeth |
  3. Dannenberger, Dirk |
  4. Ponsuksili, Siriluck |
  5. Reyer, Henry |
  6. Wimmers, Klaus |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-08-01
1000 Erschienen in
1000 Quellenangabe
  • 18(8):1674
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/ijms18081674 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578064/ |
1000 Ergänzendes Material
  • http://www.mdpi.com/1422-0067/18/8/1674#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Due to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE) twenty-four animals with extreme phenotypes regarding residual feed intake (RFI) were analyzed. Transcriptome and fatty acid profiles of liver tissue were complemented with measurements on blood parameters and thyroid hormone levels. Based on 803 differentially-abundant probe sets between low- and high-FE animals, canonical pathways like integrin signaling and lipid and carbohydrate metabolism, were shown to be affected. Molecular alterations of lipid metabolism show a pattern of a reduced hepatic usage of fatty acids in high-FE animals. Complementary analyses at the systemic level exclusively pointed to increased circulating triglycerides which were, however, accompanied by considerably lower concentrations of saturated and polyunsaturated fatty acids in the liver of high-FE pigs. These results are in accordance with altered muscle-to-fat ratios usually ascribed to FE animals. It is concluded that strategies to improve FE might favor a metabolic shift from energy storage towards energy utilization and mobilization.
1000 Sacherschließung
lokal resource efficiency
lokal liver
lokal lipid metabolism
lokal nutrient utilization
lokal gene expression
lokal feed efficiency
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/TWFnb3dhbiwgRWxpemFiZXRo|https://frl.publisso.de/adhoc/creator/RGFubmVuYmVyZ2VyLCBEaXJr|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|http://orcid.org/0000-0001-6470-0434|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. European Union |
  2. Leibniz Institute for Farm Animal Biology |
1000 Fördernummer
  1. 311794
  2. -
1000 Förderprogramm
  1. Seventh Framework Programme (FP7/2007–2013)
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Seventh Framework Programme (FP7/2007–2013)
    1000 Fördernummer 311794
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405774.rdf
1000 Erstellt am 2017-12-11T13:12:46.529+0100
1000 Erstellt von 122
1000 beschreibt frl:6405774
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 20 12:56:53 CEST 2018
1000 Objekt bearb. Wed Jun 20 12:56:53 CEST 2018
1000 Vgl. frl:6405774
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405774 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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