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1000 Titel
  • Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response
1000 Autor/in
  1. Patterson, Nicholas J. |
  2. Günther, Juliane |
  3. Gibson, Amanda J. |
  4. Offord, Victoria |
  5. Coffey, Tracey J. |
  6. Splitter, Gary |
  7. Monk, Ian |
  8. Seyfert, Hans-Martin |
  9. Werling, Dirk |
1000 Erscheinungsjahr 2014
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-12-09
1000 Erschienen in
1000 Quellenangabe
  • 5: 662
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3389/fmicb.2014.00662 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260764/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of host-species and also lacks several traditional S. aureus virulence factors. This does not, however, explain the apparent ease with which it crosses species-barriers. Recently, TIR-domain containing proteins (Tcps) which inhibit the innate immune response were identified in some Gram-negative bacteria. Here we report the presence of two proteins, S. aureus TIR-like Protein 1 (SaTlp1) and S. aureus TIR-like Protein 2 (SaTlp2), expressed by ST398 which contain domain of unknown function 1863 (DUF1863), similar to the Toll/IL-1 receptor (TIR) domain. In contrast to the Tcps in Gram-negative bacteria, our data suggest that SaTlp1 and SaTlp2 increase activation of the transcription factor NF-κB as well as downstream pro-inflammatory cytokines and immune effectors. To assess the role of both proteins as potential virulence factors knock-out mutants were created. These showed a slightly enhanced survival rate in a murine infectious model compared to the wild-type strain at one dose. Our data suggest that both proteins may act as factors contributing to the enhanced ability of ST398 to cross species-barriers.
1000 Sacherschließung
lokal TCP
lokal TLR signaling
lokal bacterial proteins
lokal mouse model
lokal innate immune response
lokal Staphylococcus aureus
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGF0dGVyc29uLCBOaWNob2xhcyBKLg==|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEp1bGlhbmU=|https://frl.publisso.de/adhoc/creator/R2lic29uLCBBbWFuZGEgSi4=|https://frl.publisso.de/adhoc/creator/T2Zmb3JkLCBWaWN0b3JpYQ==|https://frl.publisso.de/adhoc/creator/Q29mZmV5LCBUcmFjZXkgSi4=|https://frl.publisso.de/adhoc/creator/U3BsaXR0ZXIsIEdhcnk=|https://frl.publisso.de/adhoc/creator/TW9uaywgSWFu|https://frl.publisso.de/adhoc/creator/U2V5ZmVydCwgSGFucy1NYXJ0aW4=|https://frl.publisso.de/adhoc/creator/V2VybGluZywgRGlyaw==
1000 Label
1000 Förderer
  1. BBSRC iCASE |
1000 Fördernummer
  1. BB/G018073/1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer BBSRC iCASE |
    1000 Förderprogramm -
    1000 Fördernummer BB/G018073/1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405830.rdf
1000 Erstellt am 2017-12-12T15:06:21.608+0100
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 23:40:07 CET 2020
1000 Objekt bearb. Thu Jun 28 10:54:32 CEST 2018
1000 Vgl. frl:6405830
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405830 |
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