WeightNameValue
1000 Titel
  • Analysis of the real EADGENE data set: Comparison of methods and guidelines for data normalisation and selection of differentially expressed genes
1000 Autor/in
  1. Jaffrézic, Florence |
  2. de Koning, Dirk-Jan |
  3. Boettcher, Paul J. |
  4. Bonnet, Agnès |
  5. Buitenhuis, Bart |
  6. Closset, Rodrigue |
  7. Déjean, Sébastien |
  8. Delmas, Céline |
  9. Detilleux, Johanne C. |
  10. Dovč, Peter |
  11. Duval, Mylène |
  12. Foulley, Jean-Louis |
  13. Hedegaard, Jakob |
  14. Hornshøj, Henrik |
  15. Hulsegge, Ina |
  16. Janss, Luc |
  17. Jensen, Kirsty |
  18. Jiang, Li |
  19. Lavrič, Miha |
  20. Cao, Kim-Anh Lê |
  21. Lund, Mogens Sandø |
  22. Malinverni, Roberto |
  23. Marot, Guillemette |
  24. Nie, Haisheng |
  25. Petzl, Wolfram |
  26. Pool, Marco H. |
  27. Robert-Granié, Christèle |
  28. San Cristobal, Magali |
  29. van Schothorst, Evert M. |
  30. Schuberth, Hans-Joachim |
  31. Sørensen, Peter |
  32. Stella, Alessandra |
  33. Tosser-Klopp, Gwenola |
  34. Waddington, David |
  35. Watson, Michael |
  36. Yang, Wei |
  37. Zerbe, Holm |
  38. Seyfert, Hans-Martin |
1000 Erscheinungsjahr 2007
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2007-12-06
1000 Erschienen in
1000 Quellenangabe
  • 39: 633
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682811/ |
  • https://doi.org/10.1186/1297-9686-39-6-633 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A large variety of methods has been proposed in the literature for microarray data analysis. The aim of this paper was to present techniques used by the EADGENE (European Animal Disease Genomics Network of Excellence) WP1.4 participants for data quality control, normalisation and statistical methods for the detection of differentially expressed genes in order to provide some more general data analysis guidelines. All the workshop participants were given a real data set obtained in an EADGENE funded microarray study looking at the gene expression changes following artificial infection with two different mastitis causing bacteria: Escherichia coli and Staphylococcus aureus. It was reassuring to see that most of the teams found the same main biological results. In fact, most of the differentially expressed genes were found for infection by E. coli between uninfected and 24 h challenged udder quarters. Very little transcriptional variation was observed for the bacteria S. aureus. Lists of differentially expressed genes found by the different research teams were, however, quite dependent on the method used, especially concerning the data quality control step. These analyses also emphasised a biological problem of cross-talk between infected and uninfected quarters which will have to be dealt with for further microarray studies.
1000 Sacherschließung
lokal normalisation
lokal quality control
lokal microarray data
lokal differentially expressed genes
lokal mastitis resistance
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. EU |
1000 Fördernummer
  1. FOOD-CT-2004-506416
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer EU |
    1000 Förderprogramm -
    1000 Fördernummer FOOD-CT-2004-506416
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406182.rdf
1000 Erstellt am 2018-01-05T11:45:49.665+0100
1000 Erstellt von 25
1000 beschreibt frl:6406182
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon Apr 30 13:59:44 CEST 2018
1000 Objekt bearb. Mon Apr 30 13:59:43 CEST 2018
1000 Vgl. frl:6406182
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406182 |
1000 Sichtbarkeit Metadaten public
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