WeightNameValue
1000 Titel
  • Linear and generalized linear models for the detection of QTL effects on within-subject variability
1000 Autor/in
  1. Guiard, Volker |
  2. Liese, Friedrich |
  3. Reinsch, Norbert |
  4. Wittenburg, Dörte |
1000 Erscheinungsjahr 2008
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2008-01-21
1000 Erschienen in
1000 Quellenangabe
  • 89(4): 245-257
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811399/ |
  • https://doi.org/10.1017/S0016672307008968 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Quantitative trait loci (QTLs) may affect not only the mean of a trait but also its variability. A special aspect is the variability between multiple measured traits of genotyped animals, such as the within-litter variance of piglet birth weights. The sample variance of repeated measurements is assigned as an observation for every genotyped individual. It is shown that the conditional distribution of the non-normally distributed trait can be approximated by a gamma distribution. To detect QTL effects in the daughter design, a generalized linear model with the identity link function is applied. Suitable test statistics are constructed to test the null hypothesis H0: No QTL with effect on the within-litter variance is segregating versus HA: There is a QTL with effect on the variability of birth weight within litter. Furthermore, estimates of the QTL effect and the QTL position are introduced and discussed. The efficiency of the presented tests is compared with a test based on weighted regression. The error probability of the first type as well as the power of QTL detection are discussed and compared for the different tests.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/R3VpYXJkLCBWb2xrZXI=|https://frl.publisso.de/adhoc/creator/TGllc2UsIEZyaWVkcmljaA==|https://frl.publisso.de/adhoc/creator/UmVpbnNjaCwgTm9yYmVydA==|http://orcid.org/0000-0002-3639-2574
1000 Label
1000 Förderer
  1. H. Wilhelm Schaumann Stiftung |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer H. Wilhelm Schaumann Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406321.rdf
1000 Erstellt am 2018-01-15T15:22:30.462+0100
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1000 Vgl. frl:6406321
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406321 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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