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Thöne-et-al_2017_Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with HPV-an interrupted time series analysis from 2005 to 2010.pdf 1,08MB
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1000 Titel
  • Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine—an interrupted time series analysis from 2005 to 2010 using health insurance data
1000 Autor/in
  1. Thöne, Kathrin |
  2. Horn, Johannes |
  3. Mikolajczyk, Rafael |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-08-14
1000 Erschienen in
1000 Quellenangabe
  • 17: 564
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1186/s12879-017-2663-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557251/ |
1000 Ergänzendes Material
  • https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2663-7#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital warts (AGWs) were observed, but it was not clear at what level the incidence would stabilize and to what extent herd immunity would be present. Given the relatively low HPV vaccination coverage in Germany, we aimed to assess potential vaccination herd immunity effects in the German setting. METHODS: A retrospective open cohort study with data from more than nine million statutory health insurance members from 2005 to 2010 was conducted. AGW cases were identified using ICD-10-codes. The incidence of AGWs was estimated by age, sex, and calendar quarter. Age and sex specific incidence rate ratios were estimated comparing the years 2009–2010 (post-vaccination period) with 2005–2007 (pre-vaccination period). RESULTS: Incidence rate ratio of AGWs for the post-vaccination period compared to the pre-vaccination period showed a u-shaped decrease among the 14- to 24-year-old females and males which corresponds well with the reported HPV vaccination uptake in 2008. A maximum reduction of up to 60% was observed for the 16- to 20-year-old females and slightly less pronounced (up to 50%) for the 16- and 18-year-old males. Age groups outside of the range 14–24 years demonstrated no decrease. The decrease of incidence occurred in both sexes early after the vaccine recommendation and stabilized at lower levels in 2009–2010. CONCLUSIONS: A relative reduction of up to 50% among males of approximately similar age groups as that of females receiving the HPV vaccination suggests herd protection resulting from assortative mixing by age. The early decrease among males can be reduced over time due to partner change.
1000 Sacherschließung
lokal Herd immunity
lokal Anogenital warts (AGWs)
lokal Vaccine coverage
lokal Human papillomavirus (HPV) vaccine
lokal Indirect vaccination effect
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/VGjDtm5lLCBLYXRocmlu|https://frl.publisso.de/adhoc/creator/SG9ybiwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/creator/TWlrb2xhamN6eWssIFJhZmFlbCA=
1000 Förderer
  1. Helmholtz Center for Infection Research |
  2. Sanofi Pasteur MSD |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
  1. Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with HPV-an interrupted time series analysis from 2005 to 2010
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Helmholtz Center for Infection Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Sanofi Pasteur MSD |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406721.rdf
1000 Erstellt am 2018-02-16T14:08:53.577+0100
1000 Erstellt von 266
1000 beschreibt frl:6406721
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed May 16 10:15:23 CEST 2018
1000 Objekt bearb. Wed May 16 10:15:23 CEST 2018
1000 Vgl. frl:6406721
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406721 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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