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Herrmann-et-al_2014_Reference values of bone stiffness.pdf 1,09MB
WeightNameValue
1000 Titel
  • Reference values of bone stiffness index and C-terminal telopeptide in healthy European children
1000 Autor/in
  1. Herrmann, Diana |
  2. Intemann, Timm |
  3. Lauria, Fabio |
  4. Marild, Staffan |
  5. Molnar, Dénes |
  6. Moreno, Luis A. |
  7. Sioen, Isabelle |
  8. Tornaritis, Michael |
  9. Veidebaum, Toomas |
  10. Pigeot, Iris |
  11. Ahrens, Wolfgang |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
1000 Erscheinungsjahr 2014
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-09-15
1000 Erschienen in
1000 Quellenangabe
  • 38: S76-S85
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/ijo.2014.138 |
1000 Ergänzendes Material
  • https://www.nature.com/articles/ijo2014138#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND/OBJECTIVE: Quantitative ultrasound measurements and bone metabolic markers can help to monitor bone health and to detect impaired skeletal development. Population-based reference values for children may serve as a basis for preventive measures to reduce the risk of osteoporosis and osteoporotic fractures in later life. This is the first paper providing age-, sex- and height-specific reference values for bone stiffness index (SI) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) in healthy, apparently prepubertal children. SUBJECTS/METHODS: In the population-based IDEFICS baseline survey (2007–2008) and follow-up (2009–2010), 18 745 children from eight European countries were newly recruited. A total of 10 791 2–10.9-year-old and 1646 3–8.9-year-old healthy children provided data on SI of the right and left calcaneus and serum CTX, respectively. Furthermore, height and weight were measured. Percentile curves were calculated using the General Additive Model for Location Scale and Shape (GAMLSS) to model the distribution of SI and CTX depending on multiple covariates while accounting for dispersion, skewness, and the kurtosis of this distribution. RESULTS: SI was negatively associated with age and height in children aged 2–5 years, whereas a positive association was observed in children aged 6–10 years. The dip in SI occurred at older age for higher SI percentiles and was observed earlier in taller children than in smaller children. The CTX reference curves showed a linear-positive association with age and height. No major sex differences were observed for the SI and CTX reference values. CONCLUSIONS: These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug reactions during medical treatments.
1000 Sacherschließung
lokal Diagnosis
lokal Epidemiology
lokal Metabolic bone disease
lokal Paediatrics
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGVycm1hbm4sIERpYW5h|https://frl.publisso.de/adhoc/creator/SW50ZW1hbm4sIFRpbW0=|https://frl.publisso.de/adhoc/creator/TGF1cmlhLCBGYWJpbw==|https://frl.publisso.de/adhoc/creator/TWFyaWxkLCBTdGFmZmFu|https://frl.publisso.de/adhoc/creator/TW9sbmFyLCBEw6luZXM=|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlzIEEu|https://frl.publisso.de/adhoc/creator/U2lvZW4sIElzYWJlbGxl|https://frl.publisso.de/adhoc/creator/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|http://orcid.org/0000-0001-7483-0726|http://orcid.org/0000-0003-3777-570X|https://frl.publisso.de/adhoc/corporateBody/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==
1000 Förderer
  1. European community |
  2. Research Foundation Flanders |
  3. Volkswagen Foundation |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 1.2.683.14.N.00
  3. -
1000 Förderprogramm
  1. Sixth Framework Programme
  2. -
  3. -
1000 Dateien
  1. Reference values of bone stiffness index and C-terminal telopeptide in healthy European children
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European community |
    1000 Förderprogramm Sixth Framework Programme
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Research Foundation Flanders |
    1000 Förderprogramm -
    1000 Fördernummer 1.2.683.14.N.00
  3. 1000 joinedFunding-child
    1000 Förderer Volkswagen Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407160.rdf
1000 Erstellt am 2018-03-16T11:27:41.450+0100
1000 Erstellt von 266
1000 beschreibt frl:6407160
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Tue May 29 12:49:32 CEST 2018
1000 Objekt bearb. Tue May 29 12:49:32 CEST 2018
1000 Vgl. frl:6407160
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407160 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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