Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

  1. Wheeler, Eleanor
  2. Leong, Aaron
  3. Liu, Ching-Ti
  4. Hivert, Marie-France
  5. Strawbridge, Rona
  6. Podmore, Clara
  7. Li, Man
  8. Yao, Jie
  9. Sim, Xueling
  10. Hong, Jaeyoung
  11. Chu, Audrey Y.
  12. Zhang, Weihua
  13. Wang, Xu
  14. Chen, Peng
  15. Maruthur, Nisa M.
  16. Porneala, Bianca C.
  17. Sharp, Stephen
  18. Jia, Yucheng
  19. Kabagambe, Edmond K.
  20. Chang, Li-Ching
  21. Chen, Wei-Min
  22. Elks, Cathy E.
  23. Evans, Daniel
  24. Fan, Qiao
  25. Giulianini, Franco
  26. Go, Min Jin
  27. Hottenga, Jouke-Jan
  28. Hu, Yao
  29. Jackson, Anne U.
  30. Kanoni, Stavroula
  31. Kim, Young Jin
  32. Kleber, Marcus E.
  33. Ladenvall, Claes
  34. Lecoeur, Cecile
  35. Lim, Sing Hui
  36. Lu, Yingchang
  37. Mahajan, Anubha
  38. Marzi, Carola
  39. Nalls, Mike A.
  40. Navarro, Pau
  41. Nolte, Ilja M.
  42. Rose, Lynda M.
  43. Rybin, Denis V.
  44. sanna, serena
  45. Shi, Yuan
  46. Stram, Daniel O.
  47. Takeuchi, Fumihiko
  48. Tan, Shu Pei
  49. van der Most, Peter
  50. van Vliet-Ostaptchouk, Jana
  51. Wong, Andrew
  52. Yengo, Loic
  53. Zhao, Wanting
  54. Goel, Anuj
  55. Martinez Larrad, Maria Teresa
  56. Radke, Dörte
  57. Salo, Perttu
  58. Tanaka, Toshiko
  59. van Iperen, Erik P. A.
  60. Abecasis, Goncalo
  61. Afaq, Saima
  62. Ziad Alizadeh, Behrooz
  63. Bertoni, Alain G.
  64. Bonnefond, Amelie
  65. Böttcher, Yvonne
  66. Bottinger, Erwin
  67. Campbell, Harry
  68. Carlson, Olga
  69. Chen, Chien-Hsiun
  70. Cho, Yoon Shin
  71. Garvey, W. Timothy
  72. Gieger, Christian
  73. Goodarzi, Mark O.
  74. Grallert, Harald
  75. Hamsten, Anders
  76. Hartman, Catharina A.
  77. Herder, Christian
  78. Hsiung, Chao Agnes
  79. huang, jie
  80. Igase, Michiya
  81. Isono, Masato
  82. Katsuya, Tomohiro
  83. Khor, Chiea-Chuen
  84. Kiess, Wieland
  85. Kohara, Katsuhiko
  86. Kovacs, Peter
  87. Lee, Juyoung
  88. Lee, Wen-Jane
  89. Lehne, Benjamin
  90. Li, Huaixing
  91. Liu, Jianjun
  92. Lobbens, Stephane
  93. Luan, Jian'an
  94. Lyssenko, Valeriya
  95. Meitinger, Thomas
  96. Miki, Tetsuro
  97. Miljkovic, Iva
  98. Moon, Sanghoon
  99. Mulas, Antonella
  100. Müller, Gabriele
  101. Müller-Nurasyid, Martina
  102. Nagaraja, Ramaiah
  103. Nauck, Matthias
  104. Pankow, James S.
  105. Polasek, Ozren
  106. Prokopenko, Inga
  107. Ramos, Paula
  108. Rasmussen-Torvik, Laura
  109. Rathmann, Wolfgang
  110. Rich, Stephen S.
  111. Robertson, Neil R.
  112. Roden, Michael
  113. Roussel, Ronan
  114. Rudan, Igor
  115. Scott, Robert A.
  116. Scott, William R.
  117. Sennblad, Bengt
  118. Siscovick, David S.
  119. Strauch, Konstantin
  120. Sun, Liang
  121. Swertz, Morris
  122. Tajuddin, Salman M.
  123. Taylor, Kent D.
  124. Teo, Yik-Ying
  125. Tham, Yih Chung
  126. Tönjes, Anke
  127. Wareham, Nicholas
  128. Willemsen, Gonneke
  129. Wilsgaard, Tom
  130. Hingorani, Aroon
  131. EPIC-CVD Consortium
  132. EPIC-InterAct Consortium
  133. Lifelines Cohort Study
  134. Egan, Josephine
  135. Ferrucci, Luigi
  136. Hovingh, G. Kees
  137. Jula, Antti
  138. Kivimaki, Mika
  139. Kumari, Meena
  140. Njølstad, Inger
  141. Palmer, Colin
  142. Ríos, Manuel Serrano
  143. Stumvoll, Michael
  144. Watkins, Hugh
  145. Aung, Tin
  146. Blüher, Matthias
  147. Boehnke, Michael
  148. Boomsma, Dorret
  149. Bornstein, Stefan R.
  150. Chambers, John C.
  151. Chasman, Daniel I.
  152. Chen, Yii-Der Ida
  153. Chen, Yduan-Tsong
  154. Cheng, Ching-Yu
  155. CUCCA, Francesco
  156. de Geus, Eco
  157. Deloukas, Panos
  158. Evans, Michele K.
  159. Fornage, Myriam
  160. Friedlander, Yechiel
  161. Froguel, Philippe
  162. Groop, Leif
  163. Gross, Myron D.
  164. Harris, Tamara B.
  165. Hayward, Caroline
  166. Heng, Chew Kiat
  167. Ingelsson, Erik
  168. Kato, Norihiro
  169. Kim, Bong-Jo
  170. Koh, Woon-Puay
  171. Kooner, Jaspal S.
  172. Körner, Antje
  173. Kuh, Diana
  174. Kuusisto, Johanna
  175. Laakso, Markku
  176. Lin, Xu
  177. Liu, Yongmei
  178. Loos, Ruth J. F.
  179. Magnusson, Patrik
  180. März, Winfried
  181. McCarthy, Mark
  182. , Albertine
  183. Ong, Ken
  184. Pedersen, Nancy L.
  185. Pereira, Mark
  186. Peters, Annette
  187. Ridker, Paul M.
  188. Sabanayagam, Charumathi
  189. Sale, Michele
  190. Saleheen, Danish
  191. Saltevo, Juha
  192. Schwarz, Peter EH.
  193. Sheu, Wayne H. H.
  194. Snieder, Harold
  195. Spector, Timothy D.
  196. Tabara, Yasuharu
  197. Tuomilehto, Jaakko
  198. van Dam, Rob
  199. Wilson, James G.
  200. Wilson, James F
  201. Wolffenbuttel, Bruce H. R.
  202. Wong, Tien Y
  203. Wu, Jer-Yuarn
  204. Yuan, Jian-Min
  205. Zonderman, Alan B.
  206. Soranzo, Nicole
  207. Guo, Xiuqing
  208. Roberts, David J.
  209. Florez, Jose C.
  210. Sladek, Robert
  211. Dupuis, Josee
  212. Morris, Andrew
  213. Tai, E-Shyong
  214. Selvin, Elizabeth
  215. Rotter, Jerome I.
  216. Langenberg, Claudia
  217. Barroso, Ines
  218. Meigs, James B.

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WeightNameValue
1000 Titel
  • Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
1000 Autor/in
  1. Wheeler, Eleanor |
  2. Leong, Aaron |
  3. Liu, Ching-Ti |
  4. Hivert, Marie-France |
  5. Strawbridge, Rona |
  6. Podmore, Clara |
  7. Li, Man |
  8. Yao, Jie |
  9. Sim, Xueling |
  10. Hong, Jaeyoung |
  11. Chu, Audrey Y. |
  12. Zhang, Weihua |
  13. Wang, Xu |
  14. Chen, Peng |
  15. Maruthur, Nisa M. |
  16. Porneala, Bianca C. |
  17. Sharp, Stephen |
  18. Jia, Yucheng |
  19. Kabagambe, Edmond K. |
  20. Chang, Li-Ching |
  21. Chen, Wei-Min |
  22. Elks, Cathy E. |
  23. Evans, Daniel |
  24. Fan, Qiao |
  25. Giulianini, Franco |
  26. Go, Min Jin |
  27. Hottenga, Jouke-Jan |
  28. Hu, Yao |
  29. Jackson, Anne U. |
  30. Kanoni, Stavroula |
  31. Kim, Young Jin |
  32. Kleber, Marcus E. |
  33. Ladenvall, Claes |
  34. Lecoeur, Cecile |
  35. Lim, Sing Hui |
  36. Lu, Yingchang |
  37. Mahajan, Anubha |
  38. Marzi, Carola |
  39. Nalls, Mike A. |
  40. Navarro, Pau |
  41. Nolte, Ilja M. |
  42. Rose, Lynda M. |
  43. Rybin, Denis V. |
  44. sanna, serena |
  45. Shi, Yuan |
  46. Stram, Daniel O. |
  47. Takeuchi, Fumihiko |
  48. Tan, Shu Pei |
  49. van der Most, Peter |
  50. van Vliet-Ostaptchouk, Jana |
  51. Wong, Andrew |
  52. Yengo, Loic |
  53. Zhao, Wanting |
  54. Goel, Anuj |
  55. Martinez Larrad, Maria Teresa |
  56. Radke, Dörte |
  57. Salo, Perttu |
  58. Tanaka, Toshiko |
  59. van Iperen, Erik P. A. |
  60. Abecasis, Goncalo |
  61. Afaq, Saima |
  62. Ziad Alizadeh, Behrooz |
  63. Bertoni, Alain G. |
  64. Bonnefond, Amelie |
  65. Böttcher, Yvonne |
  66. Bottinger, Erwin |
  67. Campbell, Harry |
  68. Carlson, Olga |
  69. Chen, Chien-Hsiun |
  70. Cho, Yoon Shin |
  71. Garvey, W. Timothy |
  72. Gieger, Christian |
  73. Goodarzi, Mark O. |
  74. Grallert, Harald |
  75. Hamsten, Anders |
  76. Hartman, Catharina A. |
  77. Herder, Christian |
  78. Hsiung, Chao Agnes |
  79. huang, jie |
  80. Igase, Michiya |
  81. Isono, Masato |
  82. Katsuya, Tomohiro |
  83. Khor, Chiea-Chuen |
  84. Kiess, Wieland |
  85. Kohara, Katsuhiko |
  86. Kovacs, Peter |
  87. Lee, Juyoung |
  88. Lee, Wen-Jane |
  89. Lehne, Benjamin |
  90. Li, Huaixing |
  91. Liu, Jianjun |
  92. Lobbens, Stephane |
  93. Luan, Jian'an |
  94. Lyssenko, Valeriya |
  95. Meitinger, Thomas |
  96. Miki, Tetsuro |
  97. Miljkovic, Iva |
  98. Moon, Sanghoon |
  99. Mulas, Antonella |
  100. Müller, Gabriele |
  101. Müller-Nurasyid, Martina |
  102. Nagaraja, Ramaiah |
  103. Nauck, Matthias |
  104. Pankow, James S. |
  105. Polasek, Ozren |
  106. Prokopenko, Inga |
  107. Ramos, Paula |
  108. Rasmussen-Torvik, Laura |
  109. Rathmann, Wolfgang |
  110. Rich, Stephen S. |
  111. Robertson, Neil R. |
  112. Roden, Michael |
  113. Roussel, Ronan |
  114. Rudan, Igor |
  115. Scott, Robert A. |
  116. Scott, William R. |
  117. Sennblad, Bengt |
  118. Siscovick, David S. |
  119. Strauch, Konstantin |
  120. Sun, Liang |
  121. Swertz, Morris |
  122. Tajuddin, Salman M. |
  123. Taylor, Kent D. |
  124. Teo, Yik-Ying |
  125. Tham, Yih Chung |
  126. Tönjes, Anke |
  127. Wareham, Nicholas |
  128. Willemsen, Gonneke |
  129. Wilsgaard, Tom |
  130. Hingorani, Aroon |
  131. EPIC-CVD Consortium |
  132. EPIC-InterAct Consortium |
  133. Lifelines Cohort Study |
  134. Egan, Josephine |
  135. Ferrucci, Luigi |
  136. Hovingh, G. Kees |
  137. Jula, Antti |
  138. Kivimaki, Mika |
  139. Kumari, Meena |
  140. Njølstad, Inger |
  141. Palmer, Colin |
  142. Ríos, Manuel Serrano |
  143. Stumvoll, Michael |
  144. Watkins, Hugh |
  145. Aung, Tin |
  146. Blüher, Matthias |
  147. Boehnke, Michael |
  148. Boomsma, Dorret |
  149. Bornstein, Stefan R. |
  150. Chambers, John C. |
  151. Chasman, Daniel I. |
  152. Chen, Yii-Der Ida |
  153. Chen, Yduan-Tsong |
  154. Cheng, Ching-Yu |
  155. CUCCA, Francesco |
  156. de Geus, Eco |
  157. Deloukas, Panos |
  158. Evans, Michele K. |
  159. Fornage, Myriam |
  160. Friedlander, Yechiel |
  161. Froguel, Philippe |
  162. Groop, Leif |
  163. Gross, Myron D. |
  164. Harris, Tamara B. |
  165. Hayward, Caroline |
  166. Heng, Chew Kiat |
  167. Ingelsson, Erik |
  168. Kato, Norihiro |
  169. Kim, Bong-Jo |
  170. Koh, Woon-Puay |
  171. Kooner, Jaspal S. |
  172. Körner, Antje |
  173. Kuh, Diana |
  174. Kuusisto, Johanna |
  175. Laakso, Markku |
  176. Lin, Xu |
  177. Liu, Yongmei |
  178. Loos, Ruth J. F. |
  179. Magnusson, Patrik |
  180. März, Winfried |
  181. McCarthy, Mark |
  182. , Albertine |
  183. Ong, Ken |
  184. Pedersen, Nancy L. |
  185. Pereira, Mark |
  186. Peters, Annette |
  187. Ridker, Paul M. |
  188. Sabanayagam, Charumathi |
  189. Sale, Michele |
  190. Saleheen, Danish |
  191. Saltevo, Juha |
  192. Schwarz, Peter EH. |
  193. Sheu, Wayne H. H. |
  194. Snieder, Harold |
  195. Spector, Timothy D. |
  196. Tabara, Yasuharu |
  197. Tuomilehto, Jaakko |
  198. van Dam, Rob |
  199. Wilson, James G. |
  200. Wilson, James F |
  201. Wolffenbuttel, Bruce H. R. |
  202. Wong, Tien Y |
  203. Wu, Jer-Yuarn |
  204. Yuan, Jian-Min |
  205. Zonderman, Alan B. |
  206. Soranzo, Nicole |
  207. Guo, Xiuqing |
  208. Roberts, David J. |
  209. Florez, Jose C. |
  210. Sladek, Robert |
  211. Dupuis, Josee |
  212. Morris, Andrew |
  213. Tai, E-Shyong |
  214. Selvin, Elizabeth |
  215. Rotter, Jerome I. |
  216. Langenberg, Claudia |
  217. Barroso, Ines |
  218. Meigs, James B. |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-09-12
1000 Erschienen in
1000 Quellenangabe
  • 14(9):e1002383
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pmed.1002383 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595282/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002383#sec027 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.METHODS AND FINDING: Using genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04–1.06, per HbA1c-raising allele, p = 3 × 10−29); whereas GS-E was not (OR = 1.00, 95% CI 0.99–1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66–0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38–0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI 0.55–0.74) of African American adults with T2D to remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants. CONCLUSIONS: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
1000 Sacherschließung
lokal Type 2 diabetes
lokal African American people
lokal Genome-wide association studies
lokal Diabetes diagnosis and management
lokal Diabetes mellitus
lokal HbA1c
lokal Human genetics
lokal Meta-analysis
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2hlZWxlciwgRWxlYW5vcg==|https://frl.publisso.de/adhoc/creator/TGVvbmcsIEFhcm9u|http://orcid.org/0000-0002-0703-0742|http://orcid.org/0000-0001-7752-2585|http://orcid.org/0000-0001-8506-3585|http://orcid.org/0000-0002-2452-8067|http://orcid.org/0000-0002-3839-0281|https://frl.publisso.de/adhoc/creator/WWFvLCBKaWU=|http://orcid.org/0000-0002-1233-7642|https://frl.publisso.de/adhoc/creator/SG9uZywgSmFleW91bmcg|https://frl.publisso.de/adhoc/creator/Q2h1LCBBdWRyZXkgWS4g|https://frl.publisso.de/adhoc/creator/WmhhbmcsIFdlaWh1YSA=|https://frl.publisso.de/adhoc/creator/V2FuZywgWHUg|http://orcid.org/0000-0002-1422-4641|https://frl.publisso.de/adhoc/creator/TWFydXRodXIsIE5pc2EgTS4g|https://frl.publisso.de/adhoc/creator/UG9ybmVhbGEsIEJpYW5jYSBDLiA=|http://orcid.org/0000-0003-2375-1440|https://frl.publisso.de/adhoc/creator/SmlhLCBZdWNoZW5nIA==|https://frl.publisso.de/adhoc/creator/S2FiYWdhbWJlLCBFZG1vbmQgSy4g|https://frl.publisso.de/adhoc/creator/Q2hhbmcsIExpLUNoaW5nIA==|https://frl.publisso.de/adhoc/creator/Q2hlbiwgV2VpLU1pbiA=|https://frl.publisso.de/adhoc/creator/RWxrcywgQ2F0aHkgRS4g|http://orcid.org/0000-0003-4185-7687|https://frl.publisso.de/adhoc/creator/RmFuLCBRaWFvIA==|https://frl.publisso.de/adhoc/creator/R2l1bGlhbmluaSwgRnJhbmNvIA==|https://frl.publisso.de/adhoc/creator/R28sIE1pbiBKaW4g|https://frl.publisso.de/adhoc/creator/SG90dGVuZ2EsIEpvdWtlLUphbiA=|https://frl.publisso.de/adhoc/creator/SHUsIFlhbyA=|https://frl.publisso.de/adhoc/creator/SmFja3NvbiwgQW5uZSBVLiA=|https://frl.publisso.de/adhoc/creator/S2Fub25pLCBTdGF2cm91bGEg|http://orcid.org/0000-0002-4132-4437|https://frl.publisso.de/adhoc/creator/S2xlYmVyLCBNYXJjdXMgRS4g|http://orcid.org/0000-0002-7501-6598|http://orcid.org/0000-0003-0075-6417|http://orcid.org/0000-0002-3793-9658|https://frl.publisso.de/adhoc/creator/THUsIFlpbmdjaGFuZyA=|https://frl.publisso.de/adhoc/creator/TWFoYWphbiwgQW51YmhhIA==|https://frl.publisso.de/adhoc/creator/TWFyemksIENhcm9sYSA=|https://frl.publisso.de/adhoc/creator/TmFsbHMsIE1pa2UgQS4g|http://orcid.org/0000-0001-5576-8584|https://frl.publisso.de/adhoc/creator/Tm9sdGUsIElsamEgTS4g|https://frl.publisso.de/adhoc/creator/Um9zZSwgTHluZGEgTS4g|https://frl.publisso.de/adhoc/creator/UnliaW4sIERlbmlzIFYuIA==|http://orcid.org/0000-0002-3768-1749|https://frl.publisso.de/adhoc/creator/U2hpLCBZdWFuIA==|https://frl.publisso.de/adhoc/creator/U3RyYW0sIERhbmllbCBPLiA=|http://orcid.org/0000-0003-3185-5661|https://frl.publisso.de/adhoc/creator/VGFuLCBTaHUgUGVpIA==|http://orcid.org/0000-0001-8450-3518|http://orcid.org/0000-0002-7943-3153|http://orcid.org/0000-0003-2079-4779|http://orcid.org/0000-0002-4272-9305|https://frl.publisso.de/adhoc/creator/WmhhbywgV2FudGluZyA=|https://frl.publisso.de/adhoc/creator/R29lbCwgQW51aiA=|https://frl.publisso.de/adhoc/creator/TWFydGluZXogTGFycmFkLCBNYXJpYSBUZXJlc2Eg|https://frl.publisso.de/adhoc/creator/UmFka2UsIETDtnJ0ZSA=|https://frl.publisso.de/adhoc/creator/U2FsbywgUGVydHR1IA==|http://orcid.org/0000-0002-4161-3829|https://frl.publisso.de/adhoc/creator/dmFuIElwZXJlbiwgRXJpayBQLiBBLiA=|https://frl.publisso.de/adhoc/creator/QWJlY2FzaXMsIEdvbmNhbG8g|https://frl.publisso.de/adhoc/creator/QWZhcSwgU2FpbWEg|http://orcid.org/0000-0002-1415-8007|https://frl.publisso.de/adhoc/creator/QmVydG9uaSwgQWxhaW4gRy4g|https://frl.publisso.de/adhoc/creator/Qm9ubmVmb25kLCBBbWVsaWUg|https://frl.publisso.de/adhoc/creator/QsO2dHRjaGVyLCBZdm9ubmUg|http://orcid.org/0000-0001-6868-6676|http://orcid.org/0000-0002-6169-6262|http://orcid.org/0000-0003-4099-7178|https://frl.publisso.de/adhoc/creator/Q2hlbiwgQ2hpZW4tSHNpdW4g|https://frl.publisso.de/adhoc/creator/Q2hvLCBZb29uIFNoaW4g|https://frl.publisso.de/adhoc/creator/R2FydmV5LCBXLiBUaW1vdGh5IA==|https://frl.publisso.de/adhoc/creator/R2llZ2VyLCBDaHJpc3RpYW4g|https://frl.publisso.de/adhoc/creator/R29vZGFyemksIE1hcmsgTy4g|https://frl.publisso.de/adhoc/creator/R3JhbGxlcnQsIEhhcmFsZCA=|https://frl.publisso.de/adhoc/creator/SGFtc3RlbiwgQW5kZXJzIA==|https://frl.publisso.de/adhoc/creator/SGFydG1hbiwgQ2F0aGFyaW5hIEEu|http://orcid.org/0000-0002-2050-093X|https://frl.publisso.de/adhoc/creator/SHNpdW5nLCBDaGFvIEFnbmVzIA==|http://orcid.org/0000-0002-9441-4698|https://frl.publisso.de/adhoc/creator/SWdhc2UsIE1pY2hpeWEg|https://frl.publisso.de/adhoc/creator/SXNvbm8sIE1hc2F0byA=|http://orcid.org/0000-0002-8892-8828|https://frl.publisso.de/adhoc/creator/S2hvciwgQ2hpZWEtQ2h1ZW4g|https://frl.publisso.de/adhoc/creator/S2llc3MsIFdpZWxhbmQ=|https://frl.publisso.de/adhoc/creator/S29oYXJhLCBLYXRzdWhpa28g|http://orcid.org/0000-0002-0290-5423|https://frl.publisso.de/adhoc/creator/TGVlLCBKdXlvdW5nIA==|http://orcid.org/0000-0002-4390-8129|https://frl.publisso.de/adhoc/creator/TGVobmUsIEJlbmphbWluIA==|https://frl.publisso.de/adhoc/creator/TGksIEh1YWl4aW5nIA==|https://frl.publisso.de/adhoc/creator/TGl1LCBKaWFuanVuIA==|https://frl.publisso.de/adhoc/creator/TG9iYmVucywgU3RlcGhhbmUg|https://frl.publisso.de/adhoc/creator/THVhbiwgSmlhbidhbiA=|https://frl.publisso.de/adhoc/creator/THlzc2Vua28sIFZhbGVyaXlhIA==|https://frl.publisso.de/adhoc/creator/TWVpdGluZ2VyLCBUaG9tYXMg|https://frl.publisso.de/adhoc/creator/TWlraSwgVGV0c3Vybw==|http://orcid.org/0000-0002-3155-9777|https://frl.publisso.de/adhoc/creator/TW9vbiwgU2FuZ2hvb24g|https://frl.publisso.de/adhoc/creator/TXVsYXMsIEFudG9uZWxsYSA=|http://orcid.org/0000-0002-1591-0539|https://frl.publisso.de/adhoc/creator/TcO8bGxlci1OdXJhc3lpZCwgTWFydGluYSA=|https://frl.publisso.de/adhoc/creator/TmFnYXJhamEsIFJhbWFpYWg=|https://frl.publisso.de/adhoc/creator/TmF1Y2ssIE1hdHRoaWFzIA==|https://frl.publisso.de/adhoc/creator/UGFua293LCBKYW1lcyBTLg==|https://frl.publisso.de/adhoc/creator/UG9sYXNlaywgT3pyZW4=|https://frl.publisso.de/adhoc/creator/UHJva29wZW5rbywgSW5nYQ==|http://orcid.org/0000-0002-9433-6634|https://frl.publisso.de/adhoc/creator/UmFzbXVzc2VuLVRvcnZpaywgTGF1cmE=|https://frl.publisso.de/adhoc/creator/UmF0aG1hbm4sIFdvbGZnYW5nIA==|https://frl.publisso.de/adhoc/creator/UmljaCwgU3RlcGhlbiBTLg==|https://frl.publisso.de/adhoc/creator/Um9iZXJ0c29uLCBOZWlsIFIu|http://d-nb.info/gnd/130812773|https://frl.publisso.de/adhoc/creator/Um91c3NlbCwgUm9uYW4=|https://frl.publisso.de/adhoc/creator/UnVkYW4sIElnb3I=|https://frl.publisso.de/adhoc/creator/U2NvdHQsIFJvYmVydCBBLg==|https://frl.publisso.de/adhoc/creator/U2NvdHQsIFdpbGxpYW0gUi4=|https://frl.publisso.de/adhoc/creator/U2VubmJsYWQsIEJlbmd0|https://frl.publisso.de/adhoc/creator/U2lzY292aWNrLCBEYXZpZCBTLg==|https://frl.publisso.de/adhoc/creator/U3RyYXVjaCwgS29uc3RhbnRpbg==|https://frl.publisso.de/adhoc/creator/U3VuLCBMaWFuZw==|http://orcid.org/0000-0002-0979-3401|http://orcid.org/0000-0002-7919-8528|https://frl.publisso.de/adhoc/creator/VGF5bG9yLCBLZW50IEQu|https://frl.publisso.de/adhoc/creator/VGVvLCBZaWstWWluZw==|https://frl.publisso.de/adhoc/creator/VGhhbSwgWWloIENodW5n|https://frl.publisso.de/adhoc/creator/VMO2bmplcywgQW5rZQ==|http://orcid.org/0000-0003-1422-2993|https://frl.publisso.de/adhoc/creator/V2lsbGVtc2VuLCBHb25uZWtl|https://frl.publisso.de/adhoc/creator/V2lsc2dhYXJkLCBUb20=|http://orcid.org/0000-0001-8365-0081|https://frl.publisso.de/adhoc/creator/RVBJQy1DVkQgQ29uc29ydGl1bSA=|https://frl.publisso.de/adhoc/creator/RVBJQy1JbnRlckFjdCBDb25zb3J0aXVtIA==|https://frl.publisso.de/adhoc/creator/TGlmZWxpbmVzIENvaG9ydCBTdHVkeSA=|https://frl.publisso.de/adhoc/creator/RWdhbiwgSm9zZXBoaW5l|http://orcid.org/0000-0002-6273-1613|https://frl.publisso.de/adhoc/creator/SG92aW5naCwgRy4gS2Vlcw==|https://frl.publisso.de/adhoc/creator/SnVsYSwgQW50dGk=|http://orcid.org/0000-0002-4699-5627|https://frl.publisso.de/adhoc/creator/S3VtYXJpLCBNZWVuYQ==|https://frl.publisso.de/adhoc/creator/TmrDuGxzdGFkLCBJbmdlcg==|http://orcid.org/0000-0002-6415-6560|https://frl.publisso.de/adhoc/creator/UsOtb3MsIE1hbnVlbCBTZXJyYW5v|https://frl.publisso.de/adhoc/creator/U3R1bXZvbGwsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/V2F0a2lucywgSHVnaCA=|https://frl.publisso.de/adhoc/creator/QXVuZywgVGlu|https://frl.publisso.de/adhoc/creator/QmzDvGhlciwgTWF0dGhpYXM=|https://frl.publisso.de/adhoc/creator/Qm9laG5rZSwgTWljaGFlbA==|http://orcid.org/0000-0002-7099-7972|https://frl.publisso.de/adhoc/creator/Qm9ybnN0ZWluLCBTdGVmYW4gUi4g|https://frl.publisso.de/adhoc/creator/Q2hhbWJlcnMsIEpvaG4gQy4=|https://frl.publisso.de/adhoc/creator/Q2hhc21hbiwgRGFuaWVsIEku|https://frl.publisso.de/adhoc/creator/Q2hlbiwgWWlpLURlciBJZGE=|https://frl.publisso.de/adhoc/creator/Q2hlbiwgWWR1YW4tVHNvbmc=|https://frl.publisso.de/adhoc/creator/Q2hlbmcsIENoaW5nLVl1|http://orcid.org/0000-0002-7414-1995|http://orcid.org/0000-0001-6022-2666|https://frl.publisso.de/adhoc/creator/RGVsb3VrYXMsIFBhbm9z|https://frl.publisso.de/adhoc/creator/RXZhbnMsIE1pY2hlbGUgSy4=|https://frl.publisso.de/adhoc/creator/Rm9ybmFnZSwgTXlyaWFtIA==|http://orcid.org/0000-0001-6783-3531|https://frl.publisso.de/adhoc/creator/RnJvZ3VlbCwgUGhpbGlwcGU=|https://frl.publisso.de/adhoc/creator/R3Jvb3AsIExlaWYg|https://frl.publisso.de/adhoc/creator/R3Jvc3MsIE15cm9uIEQu|https://frl.publisso.de/adhoc/creator/SGFycmlzLCBUYW1hcmEgQi4=|https://frl.publisso.de/adhoc/creator/SGF5d2FyZCwgQ2Fyb2xpbmU=|http://orcid.org/0000-0002-7309-9473|https://frl.publisso.de/adhoc/creator/SW5nZWxzc29uLCBFcmlr|https://frl.publisso.de/adhoc/creator/S2F0bywgTm9yaWhpcm8=|https://frl.publisso.de/adhoc/creator/S2ltLCBCb25nLUpv|https://frl.publisso.de/adhoc/creator/S29oLCBXb29uLVB1YXk=|https://frl.publisso.de/adhoc/creator/S29vbmVyLCBKYXNwYWwgUy4=|https://frl.publisso.de/adhoc/creator/S8O2cm5lciwgQW50amU=|https://frl.publisso.de/adhoc/creator/S3VoLCBEaWFuYQ==|https://frl.publisso.de/adhoc/creator/S3V1c2lzdG8sIEpvaGFubmE=|https://frl.publisso.de/adhoc/creator/TGFha3NvLCBNYXJra3U=|https://frl.publisso.de/adhoc/creator/TGluLCBYdQ==|https://frl.publisso.de/adhoc/creator/TGl1LCBZb25nbWVp|https://frl.publisso.de/adhoc/creator/TG9vcywgUnV0aCBKLiBGLg==|http://orcid.org/0000-0002-7315-7899|https://frl.publisso.de/adhoc/creator/TcOkcnosIFdpbmZyaWVk|http://orcid.org/0000-0002-4393-0510|http://orcid.org/0000-0003-3925-3913|http://orcid.org/0000-0003-4689-7530|https://frl.publisso.de/adhoc/creator/UGVkZXJzZW4sIE5hbmN5IEwu|http://orcid.org/0000-0002-6704-5276|http://orcid.org/0000-0001-6645-0985|https://frl.publisso.de/adhoc/creator/Umlka2VyLCBQYXVsIE0u|http://orcid.org/0000-0002-4042-4719|http://orcid.org/0000-0003-1644-9040|https://frl.publisso.de/adhoc/creator/U2FsZWhlZW4sIERhbmlzaCA=|https://frl.publisso.de/adhoc/creator/U2FsdGV2bywgSnVoYQ==|https://frl.publisso.de/adhoc/creator/U2Nod2FyeiwgUGV0ZXIgRUgu|https://frl.publisso.de/adhoc/creator/U2hldSwgV2F5bmUgSC4gSC4=|https://frl.publisso.de/adhoc/creator/U25pZWRlciwgSGFyb2xk|https://frl.publisso.de/adhoc/creator/U3BlY3RvciwgVGltb3RoeSBELiA=|https://frl.publisso.de/adhoc/creator/VGFiYXJhLCBZYXN1aGFydQ==|https://frl.publisso.de/adhoc/creator/VHVvbWlsZWh0bywgSmFha2tv|http://orcid.org/0000-0002-7354-8734|https://frl.publisso.de/adhoc/creator/V2lsc29uLCBKYW1lcyBHLg==|http://orcid.org/0000-0001-5751-9178|https://frl.publisso.de/adhoc/creator/V29sZmZlbmJ1dHRlbCwgQnJ1Y2UgSC4gUi4=|http://orcid.org/0000-0002-8448-1264|https://frl.publisso.de/adhoc/creator/V3UsIEplci1ZdWFybg==|http://orcid.org/0000-0002-4620-3108|https://frl.publisso.de/adhoc/creator/Wm9uZGVybWFuLCBBbGFuIEIu|https://frl.publisso.de/adhoc/creator/U29yYW56bywgTmljb2xl|https://frl.publisso.de/adhoc/creator/R3VvLCBYaXVxaW5n|https://frl.publisso.de/adhoc/creator/Um9iZXJ0cywgRGF2aWQgSi4=|https://frl.publisso.de/adhoc/creator/RmxvcmV6LCBKb3NlIEMu|http://orcid.org/0000-0002-2730-1204|http://orcid.org/0000-0003-2871-3603|http://orcid.org/0000-0002-6805-6014|https://frl.publisso.de/adhoc/creator/VGFpLCBFLVNoeW9uZw==|https://frl.publisso.de/adhoc/creator/U2VsdmluLCBFbGl6YWJldGg=|https://frl.publisso.de/adhoc/creator/Um90dGVyLCBKZXJvbWUgSS4=|http://orcid.org/0000-0002-5017-7344|http://orcid.org/0000-0001-5800-4520|https://frl.publisso.de/adhoc/creator/TWVpZ3MsIEphbWVzIEIu
1000 Förderer
  1. Ministry of Education, Culture, Sports, Science, and Technology, Japan |
  2. Japan Science and Technology Agency |
  3. Japan Atherosclerosis Prevention Fund |
  4. Takeda Medical Research Foundation |
  5. Japanese National Cardiovascular Research |
  6. Dutch Science Organisation |
  7. CardioVascular Research Initiative |
  8. European Union |
  9. Wellcome Trust |
  10. National Heart, Lung, and Blood Institute (NHLBI) |
  11. National Human Genome Research Institute |
  12. National Institutes of Health (NIH) |
  13. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
  14. National Institute of Allergy and Infectious Diseases (NIAID) |
  15. National Human Genome Research Institute (NHGRI) |
  16. National Institute of Child Health and Human Development (NICHD) |
  17. Juvenile Diabetes Research Foundation International (JDRF) |
  18. National Institute for Health Research Cambridge Biomedical Research Centre |
  19. Medical Research Council UK |
  20. Magnus Bergvall foundation |
  21. Foundation for old servants |
  22. Andrea and Charles Bronfman Philanthropies |
  23. NIH, National Institute on Aging |
  24. National Institute of Biomedical Innovation Organization (NIBIO) |
  25. National Center for Global Health and Medicine (NCGM) |
  26. University of Alabama at Birmingham |
  27. Northwestern University |
  28. University of Minnesota |
  29. Kaiser Foundation Research Institute |
  30. Johns Hopkins University School of Medicine |
  31. Croatian Ministry of Science, Education and sports |
  32. Croatian Science Foundation |
  33. CNAMTS |
  34. Lilly |
  35. Novartis Pharma |
  36. Sanofi-Aventis |
  37. INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé) |
  38. Cohortes Santé TGIR |
  39. Association Diabète Risque Vasculaire |
  40. Fédération Française de Cardiologie |
  41. LA Fondation de France |
  42. ALFEDIAM |
  43. Société francophone du diabète |
  44. ONIVINS |
  45. Abbott |
  46. Ardix Medical |
  47. Bayer Diagnostics |
  48. Becton Dickinson |
  49. Cardionics |
  50. Merck Santé |
  51. Novo Nordisk |
  52. Pierre Fabre |
  53. Roche |
  54. Topcon |
  55. NHS Blood and Transplant (UK) |
  56. NIHR Biomedical Research Centre at Oxford |
  57. Commission of the European Communities, Directorate C - Public Health and Risk Assessment, Health & Consumer Protection |
  58. Dresden University of Technology |
  59. Academy of Finland |
  60. Kuopio University Hospital from Ministry of Health and Social Affairs |
  61. Finnish Funding Agency for Technology and Innovation |
  62. Nordic Centre of Excellence |
  63. Finnish Diabetes Research Foundation |
  64. Yrjö Jahnsson Foundation |
  65. Sigrid Juselius Foundation |
  66. TEKES |
  67. Affymetrix, Inc for genotyping services |
  68. Massachusetts General Hospital |
  69. Canadian Diabetes Association |
  70. American Diabetes Association |
  71. hospital district of Pirkanmaa |
  72. hospital district of Southern Ostrobothnia |
  73. hospital district of North Ostrobothnia |
  74. hospital district of Central Finland |
  75. hospital district of Northern Savo |
  76. Finnish National Public Health Institute |
  77. Finnish Diabetes Association |
  78. Ministry of Social Affairs and Health in Finland |
  79. Finland’s Slottery Machine Association |
  80. National Center on Minority Health and Health Disparities |
  81. Swedish Diabetes Association |
  82. Swedish Heart-Lung Foundation |
  83. German Cancer Aid |
  84. German Federal Ministry of Education and Research (BMBF) |
  85. Cancer Research UK |
  86. Spanish Ministry of Health |
  87. Murcia Regional Government |
  88. Swedish Research Council |
  89. Danish Cancer Society |
  90. Compagnia di San Paolo |
  91. Asturias Regional Government |
  92. Västerboten County Council |
  93. Dutch Ministry of Public Health, Welfare and Sports (VWS) |
  94. Netherlands Cancer Registry (NKR) |
  95. LK Research Funds |
  96. Dutch Prevention Funds |
  97. Dutch ZON (Zorg Onderzoek Nederland) |
  98. World Cancer Research Fund (WCRF) |
  99. Statistics Netherlands |
  100. Sicilian Regional Government |
  101. AIRE -ONLUS Ragusa |
  102. Imperial College Biomedical Research Centre |
  103. Dutch Diabetes Research Foundation |
  104. Korea Centers for Disease Control and Prevention |
  105. Korea National Institute of Health |
  106. State of Bavaria |
  107. Ministry of Innovation, Science, Research and Technology of the state North Rhine-Westphalia |
  108. Munich Center of Health Sciences (MC-Health) |
  109. Ludwig-Maximilians-Universität |
  110. German Research Foundation |
  111. German Diabetes Association |
  112. DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland) |
  113. Boehringer Ingelheim Foundation |
  114. Integrated Research and Treatment Centre (IFB) Adiposity Diseases |
  115. Free State of Saxony |
  116. Netherlands Organization of Scientific Research (NWO) |
  117. Dutch government |
  118. Dutch Ministry of Economic Affairs |
  119. Dutch Ministry of Education, Culture and Science |
  120. Dutch Ministry for Health, Welfare and Sports |
  121. Northern Netherlands Collaboration of Provinces (SNN) |
  122. Province of Groningen |
  123. University Medical Center Groningen |
  124. University of Groningen |
  125. Dutch Kidney Foundation |
  126. British Heart Foundation |
  127. National Institute of Health Research (NIHR) |
  128. Data Tecnica International |
  129. Finnish Heart Foundation |
  130. Finnish Diabetes Foundation |
  131. Ministry of Science and Technology of China |
  132. National Natural Science Foundation of China |
  133. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL) |
  134. Netherlands Bioinformatics Centre (NBIC) |
  135. VU University’s Institute for Health and Care Research (EMGO+ ) |
  136. Neuroscience Campus Amsterdam (NCA) |
  137. European Science Foundation (ESF) |
  138. European Science Council (ERC) |
  139. Rutgers University Cell and DNA Repository |
  140. Avera Institute, Sioux Falls, South Dakota/USA |
  141. Chief Scientist Office of the Scottish Government |
  142. AstraZeneca |
  143. Knut and Alice Wallenberg Foundation |
  144. Torsten and Ragnar Söderberg Foundation |
  145. Karolinska Institutet |
  146. Stockholm County Council |
  147. National Research Foundation, Singapore |
  148. Singapore National Medical Research Council |
  149. Fondo Europeo para el Desarrollo Regional, Red de Centros RCMN |
  150. Instituto de Salud Carlos III-RETIC |
  151. Ministerio de Ciencia e Innovación (ISCII) |
  152. Madrid Autonomous Community (MOIR) |
  153. Eli Lilly Lab, Spain |
  154. Bayer Pharmaceutical Co., Spain |
  155. Fundación Mutua Madrileña 2008, Spain |
  156. Ministry of Cultural Affairs of the Federal State of Mecklenburg - West Pomerania |
  157. Social Ministry of the Federal State of Mecklenburg - West Pomerania |
  158. Siemens Healthcare, Erlangen, Germany |
  159. Federal State of Mecklenburg- West Pomerania |
  160. National Health Research Institutes, Taiwan |
  161. National Science Council, Taiwan |
  162. National Taiwan University Hospital, Taiwan |
  163. Dutch Ministry of Justice (WODC) |
  164. Dutch Brain Foundation |
  165. Norwegian Research Council |
  166. Swedish Foundation for Strategic Research |
  167. Royal Swedish Academy of Science |
  168. Swedish Ministry for Higher Education |
  169. Swedish Diabetes Foundation |
  170. Uppsala University |
  171. Uppsala University Hospital |
  172. Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) |
  173. Academia Sinica, Taipei, Taiwan |
  174. Ministry of Science and Technology (Nation N) |
  175. National Cancer Institute |
  176. Amgen |
1000 Fördernummer
  1. 24390084; 21390099; 20390185
  2. -
  3. -
  4. -
  5. -
  6. 016.156.445
  7. CVON2011-19
  8. FP7-603091-2; FP6; LSHM_CT_2006_037197; FP7/2007-2013; 279153; FP7-279143; G51; FP7-201668; FP7-305739; HEALTH-F2-2007 201681; 257082; HEALTH-F5-2011-282510; HEALTH-F4-2007-201413; LSHG-CT-2006-018947; LSHM‐CT‐ 2007‐037273; EU/QLRT-2001-01254; QLG2-CT-2002-01254
  9. WT098017; 079895; 068545/Z/02; 076113/B/04/Z; 097451/Z/11/Z; GR072960; 083270/Z/07/Z; WT098051; 084723/Z/08/Z; 090532; 098381; WT091310; 088869/B/09/Z; 075491/Z/04
  10. HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268201100008C; HHSN268201100009C; HHSN268201100010C; HHSN268201100011C; HHSN268201100012C; R01HL087641; R01HL59367; R01HL086694; T32-HL007024; HHSN268201300025C; HHSN268201300026C;HHSN268201300027C; HHSN268201300028C; HHSN268201300029C; HHSN268200900041C; N01‐HC‐25195; HHSN268201300046C; HHSN268201300047C; HHSN268201300048C; HHSN268201300049C; HHSN268201300050C; N01-HC-95159; N01-HC-95160; N01-HC-95161; N01-HC-95162; N01-HC-95163; N01-HC-95164; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169; UL1-TR-001079; UL1-TR-000040; DK063491; HL043851; HL080467; R01HL036310
  11. U01HG004402
  12. HHSN268200625226C; UL1RR025005; 2R01DK089174; K24DK106414; R21DK080294; U01 DK062418; 1R01DK106236-01A1; HHSN268200782096C; R01D0042157-01A; MH081802; HG002651; HG005581; HL084729; RO1CA55069; R35CA53890; R01CA80205; R01CA144034; UM1 CA182876; AG028555; AG08724; AG04563; AG10175; AG08861; DK U01-066134
  13. R01 DK078616; K24 DK080140; U01 DK085526
  14. -
  15. U01-HG-004729; U01-HG-004446; U01-HG-004424
  16. -
  17. -
  18. -
  19. G0000934; G0601261; MR/M012190/1; G0601966; G0700931; K013351; MC_UU_12019/1
  20. -
  21. -
  22. -
  23. N01AG62101; N01AG62103; N01AG62106; 1R01AG032098-01A1; NO1-AG-1–2109; 263-MA-410953
  24. -
  25. -
  26. HHSN268201300025C; HHSN268201300026C
  27. HHSN268201300027C
  28. HHSN268201300028C
  29. HHSN268201300029C
  30. HHSN268200900041C
  31. 216-1080315-0302
  32. 8875
  33. -
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  36. -
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  38. -
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  55. -
  56. -
  57. 2004310
  58. -
  59. 117844; 40758; 211497; 118590; 129293; 124243
  60. 5254
  61. 40058/07
  62. 070014
  63. -
  64. 56358
  65. -
  66. 70103/06; 40058/07; 1510/31/06
  67. N02‐HL‐6‐4278
  68. -
  69. -
  70. #1-15-ACE-26
  71. -
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. human subjects protocol
  81. -
  82. 20120197
  83. -
  84. 01GI1128; 01EO1501; K6e/2; AD2-060E; 01ZZ9603; 01ZZ0103; 01ZZ0403; 03ZIK012
  85. C8221/A19170
  86. -
  87. 6236
  88. M-2005-1112; 2009-2298; 2012-1397
  89. -
  90. -
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  100. -
  101. -
  102. -
  103. 2013.81.1673
  104. 4845–301; 4851–302; 4851–307
  105. 2014-NI73001-00
  106. -
  107. -
  108. -
  109. -
  110. CRC 1052 B01;CRC 1052 B03; CRC1052/1 C05; SFB 1052; A01; C01; SPP 1629 TO 718/2-1
  111. -
  112. -
  113. -
  114. 01EO1001
  115. -
  116. 175.010.2007.006; 904-61-090; 985-10-002; 904-61-193; 480-04-004; 400-05-717; Addiction-31160008; Middelgroot-911-09-032; Spinozapremie 56-464-14192; GB-MW 940-38-011; 100-001-004; 60-60600-97-118; 261-98-710; GB-MaGW 480-01-006 and GB-MaGW 480-07-001; GB-MaGW 452-04-314 and GB-MaGW 452-06-004; 175.010.2003.005; 481-08-013; NWO 480-05-003
  117. -
  118. -
  119. -
  120. -
  121. -
  122. -
  123. -
  124. -
  125. -
  126. SP/04/002; RG/10/12/28456; PG/29605
  127. RP-PG-0407-10371
  128. -
  129. -
  130. -
  131. 2016YFC1304903
  132. 30930081; 81471013; 81170734
  133. 184.021.007
  134. 2008.024
  135. -
  136. -
  137. EU/QLRT-2001-01254; FP-006
  138. 230374
  139. NIMH U24 MH068457-06
  140. -
  141. CZB/4/276; CZB/4/710
  142. -
  143. -
  144. -
  145. -
  146. 560283
  147. 370062002
  148. 1270/2010
  149. FEDER 2FD 1997/2309; C03/08
  150. RD06/0015/0012; FIS 03/1618
  151. -
  152. S2010/BMD-2423
  153. -
  154. -
  155. -
  156. -
  157. -
  158. -
  159. -
  160. PH-100-SP-01; BS-094-PP-01; PH-100-PP-03
  161. NSC 98-2314-B-075A-002-MY3; NSC 96-2314-B-002-151; NSC 96-2314-B-002-152; NSC 98-2314-B-002-122-MY2; NSC 100-2314-B-002-115; NSC 101-2325-002-078; 101-2314-B-075A-006-MY3
  162. NTUH 98-N1266; NTUH 100-N1775; NTUH 101-N2010; NTUH 101-N; VN101-04; NTUH 101-S1784
  163. -
  164. -
  165. -
  166. -
  167. -
  168. -
  169. 2013-024
  170. -
  171. -
  172. b2011036
  173. -
  174. -
  175. CA047988; UM1CA182913
  176. -
1000 Förderprogramm
  1. -
  2. Science and Technology Incubation Program in Advanced Regions; Core Research for Evolutional Science and Technology (CREST)
  3. -
  4. -
  5. -
  6. -
  7. Genius
  8. Beta-JUDO; European Regional Development Fund (ERDF); EpiMigrant; Action on Hearing Loss; AtheroRemo; RiskyCAD; EPIGENESYS; BLUEPRINT; EUROSPAN; ENGAGE; GenomEUtwin
  9. Senior Fellowship in Basic Biomedical Science; Strategic Award; Biomedical Collections
  10. Cardiovascular Epidemiology Training; Framingham Heart Study
  11. -
  12. Roadmap for Medical Research
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. -
  23. Intramural Research Program
  24. Program for Promotion of Fundamental Studies in Health Sciences
  25. -
  26. -
  27. -
  28. -
  29. -
  30. -
  31. -
  32. -
  33. -
  34. -
  35. -
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  48. -
  49. -
  50. -
  51. -
  52. -
  53. -
  54. -
  55. -
  56. -
  57. -
  58. Med Drive
  59. -
  60. EVO
  61. -
  62. Systems biology in controlled dietary interventions and cohort studies, SYSDIET
  63. -
  64. -
  65. -
  66. -
  67. -
  68. MGH Research Scholars Award
  69. Postdoctoral Research fellowship
  70. Pathway Accelerator Award
  71. -
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. # Z01-AG000513; 09-AG-N248
  81. -
  82. -
  83. -
  84. German Obesity Biomaterial Bank
  85. -
  86. Health Research Fund (FIS)
  87. -
  88. -
  89. -
  90. -
  91. -
  92. -
  93. -
  94. -
  95. -
  96. -
  97. -
  98. -
  99. -
  100. -
  101. -
  102. -
  103. Diabetes Funds Junior Fellowship
  104. -
  105. -
  106. -
  107. -
  108. -
  109. LMUinnovativ
  110. "Obesity mechanisms”
  111. -
  112. -
  113. -
  114. -
  115. -
  116. NWO Longitudinal Survey and Panel Funding; NWO large-sized investment; Medical Research Council program; ZonMW Brainpower; ZonMw Risk Behavior and Dependence; ZonMw Culture and Health; Social Sciences Council medium-sized investment; Social Sciences Council project
  117. -
  118. -
  119. -
  120. -
  121. -
  122. -
  123. -
  124. -
  125. -
  126. -
  127. -
  128. -
  129. -
  130. -
  131. -
  132. -
  133. -
  134. BioAssist/RK
  135. -
  136. -
  137. EuroSTRESS
  138. -
  139. -
  140. -
  141. -
  142. -
  143. Wallenberg Academy Fellow
  144. -
  145. Strategic Cardiovascular Program; SRP diabetes
  146. Strategic Cardiovascular Program
  147. HUJ-CREATE
  148. -
  149. -
  150. -
  151. -
  152. -
  153. -
  154. -
  155. -
  156. -
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Ministry of Education, Culture, Sports, Science, and Technology, Japan |
    1000 Förderprogramm -
    1000 Fördernummer 24390084; 21390099; 20390185
  2. 1000 joinedFunding-child
    1000 Förderer Japan Science and Technology Agency |
    1000 Förderprogramm Science and Technology Incubation Program in Advanced Regions; Core Research for Evolutional Science and Technology (CREST)
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Japan Atherosclerosis Prevention Fund |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Takeda Medical Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Japanese National Cardiovascular Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Dutch Science Organisation |
    1000 Förderprogramm -
    1000 Fördernummer 016.156.445
  7. 1000 joinedFunding-child
    1000 Förderer CardioVascular Research Initiative |
    1000 Förderprogramm Genius
    1000 Fördernummer CVON2011-19
  8. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Beta-JUDO; European Regional Development Fund (ERDF); EpiMigrant; Action on Hearing Loss; AtheroRemo; RiskyCAD; EPIGENESYS; BLUEPRINT; EUROSPAN; ENGAGE; GenomEUtwin
    1000 Fördernummer FP7-603091-2; FP6; LSHM_CT_2006_037197; FP7/2007-2013; 279153; FP7-279143; G51; FP7-201668; FP7-305739; HEALTH-F2-2007 201681; 257082; HEALTH-F5-2011-282510; HEALTH-F4-2007-201413; LSHG-CT-2006-018947; LSHM‐CT‐ 2007‐037273; EU/QLRT-2001-01254; QLG2-CT-2002-01254
  9. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm Senior Fellowship in Basic Biomedical Science; Strategic Award; Biomedical Collections
    1000 Fördernummer WT098017; 079895; 068545/Z/02; 076113/B/04/Z; 097451/Z/11/Z; GR072960; 083270/Z/07/Z; WT098051; 084723/Z/08/Z; 090532; 098381; WT091310; 088869/B/09/Z; 075491/Z/04
  10. 1000 joinedFunding-child
    1000 Förderer National Heart, Lung, and Blood Institute (NHLBI) |
    1000 Förderprogramm Cardiovascular Epidemiology Training; Framingham Heart Study
    1000 Fördernummer HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268201100008C; HHSN268201100009C; HHSN268201100010C; HHSN268201100011C; HHSN268201100012C; R01HL087641; R01HL59367; R01HL086694; T32-HL007024; HHSN268201300025C; HHSN268201300026C;HHSN268201300027C; HHSN268201300028C; HHSN268201300029C; HHSN268200900041C; N01‐HC‐25195; HHSN268201300046C; HHSN268201300047C; HHSN268201300048C; HHSN268201300049C; HHSN268201300050C; N01-HC-95159; N01-HC-95160; N01-HC-95161; N01-HC-95162; N01-HC-95163; N01-HC-95164; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169; UL1-TR-001079; UL1-TR-000040; DK063491; HL043851; HL080467; R01HL036310
  11. 1000 joinedFunding-child
    1000 Förderer National Human Genome Research Institute |
    1000 Förderprogramm -
    1000 Fördernummer U01HG004402
  12. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health (NIH) |
    1000 Förderprogramm Roadmap for Medical Research
    1000 Fördernummer HHSN268200625226C; UL1RR025005; 2R01DK089174; K24DK106414; R21DK080294; U01 DK062418; 1R01DK106236-01A1; HHSN268200782096C; R01D0042157-01A; MH081802; HG002651; HG005581; HL084729; RO1CA55069; R35CA53890; R01CA80205; R01CA144034; UM1 CA182876; AG028555; AG08724; AG04563; AG10175; AG08861; DK U01-066134
  13. 1000 joinedFunding-child
    1000 Förderer National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
    1000 Förderprogramm -
    1000 Fördernummer R01 DK078616; K24 DK080140; U01 DK085526
  14. 1000 joinedFunding-child
    1000 Förderer National Institute of Allergy and Infectious Diseases (NIAID) |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer National Human Genome Research Institute (NHGRI) |
    1000 Förderprogramm -
    1000 Fördernummer U01-HG-004729; U01-HG-004446; U01-HG-004424
  16. 1000 joinedFunding-child
    1000 Förderer National Institute of Child Health and Human Development (NICHD) |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer Juvenile Diabetes Research Foundation International (JDRF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer National Institute for Health Research Cambridge Biomedical Research Centre |
    1000 Förderprogramm -
    1000 Fördernummer -
  19. 1000 joinedFunding-child
    1000 Förderer Medical Research Council UK |
    1000 Förderprogramm -
    1000 Fördernummer G0000934; G0601261; MR/M012190/1; G0601966; G0700931; K013351; MC_UU_12019/1
  20. 1000 joinedFunding-child
    1000 Förderer Magnus Bergvall foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  21. 1000 joinedFunding-child
    1000 Förderer Foundation for old servants |
    1000 Förderprogramm -
    1000 Fördernummer -
  22. 1000 joinedFunding-child
    1000 Förderer Andrea and Charles Bronfman Philanthropies |
    1000 Förderprogramm -
    1000 Fördernummer -
  23. 1000 joinedFunding-child
    1000 Förderer NIH, National Institute on Aging |
    1000 Förderprogramm Intramural Research Program
    1000 Fördernummer N01AG62101; N01AG62103; N01AG62106; 1R01AG032098-01A1; NO1-AG-1–2109; 263-MA-410953
  24. 1000 joinedFunding-child
    1000 Förderer National Institute of Biomedical Innovation Organization (NIBIO) |
    1000 Förderprogramm Program for Promotion of Fundamental Studies in Health Sciences
    1000 Fördernummer -
  25. 1000 joinedFunding-child
    1000 Förderer National Center for Global Health and Medicine (NCGM) |
    1000 Förderprogramm -
    1000 Fördernummer -
  26. 1000 joinedFunding-child
    1000 Förderer University of Alabama at Birmingham |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300025C; HHSN268201300026C
  27. 1000 joinedFunding-child
    1000 Förderer Northwestern University |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300027C
  28. 1000 joinedFunding-child
    1000 Förderer University of Minnesota |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300028C
  29. 1000 joinedFunding-child
    1000 Förderer Kaiser Foundation Research Institute |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268201300029C
  30. 1000 joinedFunding-child
    1000 Förderer Johns Hopkins University School of Medicine |
    1000 Förderprogramm -
    1000 Fördernummer HHSN268200900041C
  31. 1000 joinedFunding-child
    1000 Förderer Croatian Ministry of Science, Education and sports |
    1000 Förderprogramm -
    1000 Fördernummer 216-1080315-0302
  32. 1000 joinedFunding-child
    1000 Förderer Croatian Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 8875
  33. 1000 joinedFunding-child
    1000 Förderer CNAMTS |
    1000 Förderprogramm -
    1000 Fördernummer -
  34. 1000 joinedFunding-child
    1000 Förderer Lilly |
    1000 Förderprogramm -
    1000 Fördernummer -
  35. 1000 joinedFunding-child
    1000 Förderer Novartis Pharma |
    1000 Förderprogramm -
    1000 Fördernummer -
  36. 1000 joinedFunding-child
    1000 Förderer Sanofi-Aventis |
    1000 Förderprogramm -
    1000 Fördernummer -
  37. 1000 joinedFunding-child
    1000 Förderer INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé) |
    1000 Förderprogramm -
    1000 Fördernummer -
  38. 1000 joinedFunding-child
    1000 Förderer Cohortes Santé TGIR |
    1000 Förderprogramm -
    1000 Fördernummer -
  39. 1000 joinedFunding-child
    1000 Förderer Association Diabète Risque Vasculaire |
    1000 Förderprogramm -
    1000 Fördernummer -
  40. 1000 joinedFunding-child
    1000 Förderer Fédération Française de Cardiologie |
    1000 Förderprogramm -
    1000 Fördernummer -
  41. 1000 joinedFunding-child
    1000 Förderer LA Fondation de France |
    1000 Förderprogramm -
    1000 Fördernummer -