Download
s12864-018-4584-2.pdf 809,28KB
WeightNameValue
1000 Titel
  • Lowered dietary phosphorus affects intestinal and renal gene expression to maintain mineral homeostasis with immunomodulatory implications in weaned piglets
1000 Autor/in
  1. Just, Franziska |
  2. Oster, Michael |
  3. Büsing, Kirsten |
  4. Borgelt, Luisa |
  5. Murani, Eduard |
  6. Ponsuksili, Siriluck |
  7. Wolf, Petra |
  8. Wimmers, Klaus |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-03-20
1000 Erschienen in
1000 Quellenangabe
  • 19:207
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12864-018-4584-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859397/ |
1000 Ergänzendes Material
  • https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4584-2#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: In monogastric animals, phosphorus (P) homeostasis is maintained by regulating intestinal absorption, bone mobilization, and renal excretion. Since P is a non-renewable resource, a shortage is imminent due to widespread over-usage in the farming and animal husbandry industries. As a consequence, P efficiency should be improved in pig production. We sought to characterize the transcriptional response in re−/absorbing and excreting tissues in pigs to diets varying in calcium: phosphorus ratios. Weaned piglets were assigned to one of three groups fed diets varying in digestible P content for a period of five weeks. Gene expression profiles were analyzed in jejunum, colon, and kidney. RESULTS: Transcriptome analysis revealed that reduced dietary P intake affects gene expression in jejunum and kidney, but not in colon. The regulation of mineral homeostasis was reflected via altered mRNA abundances of CYP24A1, CYP27A1, TRPM6, SPP1, and VDR in jejunum and kidney. Moreover, lowered abundances of transcripts associated with the classical complement system pathway were observed in the jejunum. In kidney, shifted transcripts were involved in phospholipase C, calcium signaling, and NFAT signaling, which may have immunomodulatory implications. CONCLUSIONS: Our results revealed local transcriptional consequences of variable P intake in intestinal and renal tissues. The adaptive responses are the result of organismal efforts to maintain systemic mineral homeostasis while modulating immune features at local tissue sites. Therefore, the deviation from the currently recommended dietary P supply must be carefully considered, as the endogenous mechanisms that respond to low P diets may impact important adaptive immune responses.
1000 Sacherschließung
lokal Immune response
lokal Diet
lokal Phosphorus ratio
lokal Gene expression
lokal Pig
1000 Fachgruppe
  1. Biologie |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SnVzdCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/QsO8c2luZywgS2lyc3Rlbg==|https://frl.publisso.de/adhoc/creator/Qm9yZ2VsdCwgTHVpc2E=|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/V29sZiwgUGV0cmE=|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. Leibniz Science Campus Phosphorus Research Rostock |
  2. European Union |
  3. Leibniz Institute for Farm Animal Biology (FBN) |
  4. Leibniz Association |
1000 Fördernummer
  1. -
  2. FP7/2007–2013; 311794
  3. -
  4. -
1000 Förderprogramm
  1. -
  2. Seventh Framework Programme; ECO-FCE project
  3. Open Access Fund
  4. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Science Campus Phosphorus Research Rostock |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Seventh Framework Programme; ECO-FCE project
    1000 Fördernummer FP7/2007–2013; 311794
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407996.rdf
1000 Erstellt am 2018-05-09T09:42:25.965+0200
1000 Erstellt von 25
1000 beschreibt frl:6407996
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 18:56:17 CET 2020
1000 Objekt bearb. Wed May 09 09:43:20 CEST 2018
1000 Vgl. frl:6407996
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407996 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source