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Phillippo-et-al_2017_Sensitivity of treatment recommendations to bias in network meta-analysis.pdf 814,83KB
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1000 Titel
  • Sensitivity of treatment recommendations to bias in network meta-analysis
1000 Autor/in
  1. Phillippo, David M. |
  2. Dias, Sofia |
  3. Ades, A. E. |
  4. Didelez, Vanessa |
  5. Welton, Nicky J. |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-12-06
1000 Erschienen in
1000 Quellenangabe
  • 181(3): 843-867
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1111/rssa.12341 |
1000 Ergänzendes Material
  • https://rss.onlinelibrary.wiley.com/doi/abs/10.1111/rssa.12341 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Network meta‐analysis (NMA) pools evidence on multiple treatments to estimate relative treatment effects. Included studies are typically assessed for risk of bias; however, this provides no indication of the impact of potential bias on a decision based on the NMA. We propose methods to derive bias adjustment thresholds which measure the smallest changes to the data that result in a change of treatment decision. The methods use efficient matrix operations and can be applied to explore the consequences of bias in individual studies or aggregate treatment contrasts, in both fixed and random‐effects NMA models. Complex models with multiple types of data input are handled by using an approximation to the hypothetical aggregate likelihood. The methods are illustrated with a simple NMA of thrombolytic treatments and a more complex example comparing social anxiety interventions. An accompanying R package is provided.
1000 Sacherschließung
lokal Mixed treatment comparison
lokal Threshold analysis
lokal Risk of bias
lokal Quality of evidence
lokal Influence matrix
lokal Evidence synthesis
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGhpbGxpcHBvLCBEYXZpZCBNLg==|https://frl.publisso.de/adhoc/creator/RGlhcywgU29maWE=|https://frl.publisso.de/adhoc/creator/QWRlcywgQS4gRS4=|https://frl.publisso.de/adhoc/creator/RGlkZWxleiwgVmFuZXNzYQ==|https://frl.publisso.de/adhoc/creator/V2VsdG9uLCBOaWNreSBKLg==
1000 Label
1000 Förderer
  1. Centre for Clinical Practice, National Institute for Health and Care Excellence |
1000 Fördernummer
  1. MR/K025643/1; MR/M005232/1
1000 Förderprogramm
  1. -
1000 Dateien
  1. Sensitivity of treatment recommendations to bias in network meta-analysis
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Centre for Clinical Practice, National Institute for Health and Care Excellence |
    1000 Förderprogramm -
    1000 Fördernummer MR/K025643/1; MR/M005232/1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408135.rdf
1000 Erstellt am 2018-05-28T15:09:53.620+0200
1000 Erstellt von 266
1000 beschreibt frl:6408135
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 21:33:42 CET 2020
1000 Objekt bearb. Fri Jun 15 13:13:59 CEST 2018
1000 Vgl. frl:6408135
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408135 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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