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1000 Titel
  • A DNA methylation biomarker of alcohol consumption
1000 Autor/in
  1. Liu, C |
  2. Marioni, R E |
  3. Hedman, Å K |
  4. Pfeiffer, L |
  5. Tsai, P-C |
  6. Reynolds, L M |
  7. Just, A C |
  8. Duan, Q |
  9. Boer, C G |
  10. Tanaka, T |
  11. Elks, C E |
  12. Aslibekyan, S |
  13. Brody, J A |
  14. Kühnel, B |
  15. Herder, Christian |
  16. Almli, L M |
  17. Zhi, D |
  18. Wang, Y |
  19. Huan, T |
  20. Yao, C |
  21. Mendelson, M M |
  22. Joehanes, R |
  23. Liang, L |
  24. Love, S-A |
  25. Guan, W |
  26. Shah, S |
  27. McRae, A F |
  28. Kretschmer, A |
  29. Prokisch, H |
  30. Strauch, K |
  31. Peters, A |
  32. Visscher, P M |
  33. Wray, N R |
  34. Guo, X |
  35. Wiggins, K L |
  36. Smith, A K |
  37. Binder, E B |
  38. Ressler, K J |
  39. Irvin, M R |
  40. Absher, D M |
  41. Hernandez, D |
  42. Ferrucci, L |
  43. Bandinelli, S |
  44. Lohman, K |
  45. Ding, J |
  46. Trevisi, L |
  47. Gustafsson, S |
  48. Sandling, J H |
  49. Stolk, L |
  50. Uitterlinden, A G |
  51. Yet, I |
  52. Castillo-Fernandez, J E |
  53. Spector, T D |
  54. Schwartz, J D |
  55. Vokonas, P |
  56. Lind, L |
  57. Li, Y |
  58. Fornage, M |
  59. Arnett, D K |
  60. Wareham, N J |
  61. Sotoodehnia, N |
  62. Ong, K K |
  63. van Meurs, J B J |
  64. Conneely, K N |
  65. Baccarelli, A A |
  66. Deary, I J |
  67. Bell, J T |
  68. North, K E |
  69. Liu, Y |
  70. Waldenberger, M |
  71. London, S J |
  72. Ingelsson, E |
  73. Levy, D |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-11-15
1000 Erschienen in
1000 Quellenangabe
  • 23:422-433
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/mp.2016.192 |
  • https://www.ncbi.nlm.nih.gov/pubmed/27843151 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575985/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/mp2016192#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42–76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=6926) and identified 144 CpGs that provided substantial discrimination (area under the curve=0.90–0.99) for current heavy alcohol intake (42 g per day in men and 28 g per day in women) in four replication cohorts. The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry samples) and 165 (2423 African ancestry samples) alcohol-related CpGs at Bonferroni-adjusted P<1 × 10−7. Analysis of the monocyte-derived DNA (n=1251) identified 62 alcohol-related CpGs at P<1 × 10-7. In whole-blood samples of people of European ancestry, we detected differential methylation in two neurotransmitter receptor genes, the γ-Aminobutyric acid-A receptor delta and γ-aminobutyric acid B receptor subunit 1; their differential methylation was associated with expression levels of a number of genes involved in immune function. In conclusion, we have identified a robust alcohol-related DNA methylation signature and shown the potential utility of DNA methylation as a clinically useful diagnostic test to detect current heavy alcohol consumption.
1000 Sacherschließung
lokal Genetics
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. European Research Council (ERC) |
  2. Wellcome Trust |
  3. European Community |
  4. National Institute for Health Research (NIHR) |
  5. Guy’s and St Thomas’ NHS Foundation Trust |
  6. King’s College London |
  7. NIH/CIDR |
1000 Fördernummer
  1. 250157
  2. -
  3. FP7/2007-2013
  4. -
  5. -
  6. -
  7. -
1000 Förderprogramm
  1. Advanced Principal Investigator award
  2. -
  3. Seventh Framework Programme
  4. -
  5. -
  6. -
  7. -
1000 Dateien
  1. A DNA methylation biomarker of alcohol consumption
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Research Council (ERC) |
    1000 Förderprogramm Advanced Principal Investigator award
    1000 Fördernummer 250157
  2. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Seventh Framework Programme
    1000 Fördernummer FP7/2007-2013
  4. 1000 joinedFunding-child
    1000 Förderer National Institute for Health Research (NIHR) |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Guy’s and St Thomas’ NHS Foundation Trust |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer King’s College London |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer NIH/CIDR |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408141.rdf
1000 Erstellt am 2018-05-29T14:23:48.717+0200
1000 Erstellt von 218
1000 beschreibt frl:6408141
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue Oct 25 15:38:01 CEST 2022
1000 Objekt bearb. Tue Oct 25 15:38:01 CEST 2022
1000 Vgl. frl:6408141
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408141 |
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1000 Sichtbarkeit Daten public
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