HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

  1. Connell, Marisa ORCID logo
  2. Chen, Helen
  3. Jiang, Jihong
  4. Kuan, Chia-Wei
  5. Fotovati, Abbas
  6. Chu, Tony LH
  7. He, Zhengcheng
  8. Lengyell, Tess C.
  9. Li, Huaibiao ORCID logo
  10. Kroll, Torsten ORCID logo
  11. Li, Amanda M.
  12. Goldowitz, Daniel ORCID logo
  13. Frappart, Lucien
  14. Ploubidou, Aspasia
  15. Patel, Millan ORCID logo
  16. Pilarski, Linda M.
  17. Simpson, Elizabeth ORCID logo
  18. Lange, Philipp ORCID logo
  19. Allan, Douglas W.
  20. Maxwell, Christopher ORCID logo

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WeightNameValue
1000 Titel
  • HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development
1000 Autor/in
  1. Connell, Marisa |
  2. Chen, Helen |
  3. Jiang, Jihong |
  4. Kuan, Chia-Wei |
  5. Fotovati, Abbas |
  6. Chu, Tony LH |
  7. He, Zhengcheng |
  8. Lengyell, Tess C. |
  9. Li, Huaibiao |
  10. Kroll, Torsten |
  11. Li, Amanda M. |
  12. Goldowitz, Daniel |
  13. Frappart, Lucien |
  14. Ploubidou, Aspasia |
  15. Patel, Millan |
  16. Pilarski, Linda M. |
  17. Simpson, Elizabeth |
  18. Lange, Philipp |
  19. Allan, Douglas W. |
  20. Maxwell, Christopher |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-10-10
1000 Erschienen in
1000 Quellenangabe
  • 6:e28672
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.7554/eLife.28672 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28994651/ |
1000 Ergänzendes Material
  • https://elifesciences.org/articles/28672/figures |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Oriented cell division is one mechanism progenitor cells use during development and to maintain tissue homeostasis. Common to most cell types is the asymmetric establishment and regulation of cortical NuMA-dynein complexes that position the mitotic spindle. Here, we discover that HMMR acts at centrosomes in a PLK1-dependent pathway that locates active Ran and modulates the cortical localization of NuMA-dynein complexes to correct mispositioned spindles. This pathway was discovered through the creation and analysis of Hmmr-knockout mice, which suffer neonatal lethality with defective neural development and pleiotropic phenotypes in multiple tissues. HMMR over-expression in immortalized cancer cells induces phenotypes consistent with an increase in active Ran including defects in spindle orientation. These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development.
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-7594-2137|https://frl.publisso.de/adhoc/creator/Q2hlbiwgSGVsZW4=|https://frl.publisso.de/adhoc/creator/SmlhbmcsIEppaG9uZw==|https://frl.publisso.de/adhoc/creator/S3VhbiwgQ2hpYS1XZWk=|https://frl.publisso.de/adhoc/creator/Rm90b3ZhdGksIEFiYmFz|https://frl.publisso.de/adhoc/creator/Q2h1LCBUb255IExI|https://frl.publisso.de/adhoc/creator/IEhlLCBaaGVuZ2NoZW5n|https://frl.publisso.de/adhoc/creator/TGVuZ3llbGwsIFRlc3MgQy4=|http://orcid.org/0000-0003-4086-3321|http://orcid.org/0000-0002-9376-5867|https://frl.publisso.de/adhoc/creator/TGksIEFtYW5kYSBNLg==|http://orcid.org/0000-0003-4756-4017|https://frl.publisso.de/adhoc/creator/RnJhcHBhcnQsIEx1Y2llbg==|https://frl.publisso.de/adhoc/creator/UGxvdWJpZG91LCBBc3Bhc2lh|http://orcid.org/0000-0001-7061-6837|https://frl.publisso.de/adhoc/creator/UGlsYXJza2ksIExpbmRhIE0u|http://orcid.org/0000-0002-0654-4303|http://orcid.org/0000-0003-1171-5864|https://frl.publisso.de/adhoc/creator/QWxsYW4sIERvdWdsYXMgVy4=|http://orcid.org/0000-0002-0860-4031
1000 Förderer
  1. Michael Cuccione Foundation
  2. Canadian Breast Cancer Foundation
  3. BC Children’s Hospital Research Institute
  4. Canada Research Chairs
  5. Michael Smith Foundation for Health Research
  6. Canadian Institutes of Health Research
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. -
  6. OBC 134038
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
1000 Dateien
1000 Objektart article
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1000 @id frl:6408316.rdf
1000 Erstellt am 2018-06-14T15:28:44.847+0200
1000 Erstellt von 285
1000 beschreibt frl:6408316
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Jun 20 13:33:43 CEST 2018
1000 Objekt bearb. Wed Jun 20 13:33:22 CEST 2018
1000 Vgl. frl:6408316
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408316 |
1000 Sichtbarkeit Metadaten public
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