Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

  1. Horikoshi, Momoko
  2. Mӓgi, Reedik
  3. van de Bunt, Martijn
  4. Surakka, Ida
  5. Sarin, Antti-Pekka
  6. Mahajan, Anubha
  7. Marullo, Letizia
  8. Thorleifsson, Gudmar
  9. Hägg, Sara
  10. Hottenga, Jouke-Jan
  11. Ladenvall, Claes
  12. Ried, Janina S.
  13. Winkler, Thomas W.
  14. Willems, Sara M.
  15. Pervjakova, Natalia
  16. Esko, Tõnu
  17. Beekman, Marian
  18. Nelson, Christopher P.
  19. Willenborg, Christina
  20. Wiltshire, Steven
  21. Ferreira, Teresa
  22. Fernandez, Juan
  23. Gaulton, Kyle J.
  24. Steinthorsdottir, Valgerdur
  25. Hamsten, Anders
  26. Magnusson, Patrik K. E.
  27. Willemsen, Gonneke
  28. Milaneschi, Yuri
  29. Robertson, Neil R.
  30. Groves, Christopher J.
  31. Bennett, Amanda J.
  32. Lehtimäki, Terho
  33. Viikari, Jorma S.
  34. Rung, Johan
  35. Lyssenko, Valeriya
  36. Perola, Markus
  37. Heid, Iris M.
  38. Herder, Christian ORCID logo
  39. Grallert, Harald
  40. Müller-Nurasyid, Martina
  41. Hypponen, Elina
  42. Roden, Michael
  43. Isaacs, Aaron
  44. van Leeuwen, Elisabeth M.
  45. Karssen, Lennart C.
  46. Mihailov, Evelin
  47. Houwing-Duistermaat, Jeanine J.
  48. de Craen, Anton J. M.
  49. Deelen, Joris
  50. Havulinna, Aki S.
  51. Blades, Matthew
  52. Hengstenberg, Christian
  53. Erdmann, Jeanette
  54. Schunkert, Heribert
  55. Kaprio, Jaakko
  56. Tobin, Martin D.
  57. Samani, Nilesh J.
  58. Lind, Lars
  59. Salomaa, Veikko
  60. Lindgren, Cecilia M.
  61. Slagboom, P. Eline
  62. Metspalu, Andres
  63. van Duijn, Cornelia M.
  64. Eriksson, Johan G.
  65. Peters, Annette
  66. Gieger, Christian
  67. Jula, Antti
  68. Groop, Leif
  69. Raitakari, Olli T.
  70. Power, Chris
  71. Penninx, Brenda W. J. H.
  72. de Geus, Eco
  73. Smit, Johannes H.
  74. Boomsma, Dorret I.
  75. Pedersen, Nancy L.
  76. Ingelsson, Erik
  77. Thorsteinsdottir, Unnur
  78. Stefansson, Kari
  79. Ripatti, Samuli
  80. Prokopenko, Inga
  81. McCarthy, Mark I.
  82. Morris, Andrew P.
  83. ENGAGE Consortium

Download
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.pdf 2,12MB
WeightNameValue
1000 Titel
  • Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
1000 Autor/in
  1. Horikoshi, Momoko |
  2. Mӓgi, Reedik |
  3. van de Bunt, Martijn |
  4. Surakka, Ida |
  5. Sarin, Antti-Pekka |
  6. Mahajan, Anubha |
  7. Marullo, Letizia |
  8. Thorleifsson, Gudmar |
  9. Hägg, Sara |
  10. Hottenga, Jouke-Jan |
  11. Ladenvall, Claes |
  12. Ried, Janina S. |
  13. Winkler, Thomas W. |
  14. Willems, Sara M. |
  15. Pervjakova, Natalia |
  16. Esko, Tõnu |
  17. Beekman, Marian |
  18. Nelson, Christopher P. |
  19. Willenborg, Christina |
  20. Wiltshire, Steven |
  21. Ferreira, Teresa |
  22. Fernandez, Juan |
  23. Gaulton, Kyle J. |
  24. Steinthorsdottir, Valgerdur |
  25. Hamsten, Anders |
  26. Magnusson, Patrik K. E. |
  27. Willemsen, Gonneke |
  28. Milaneschi, Yuri |
  29. Robertson, Neil R. |
  30. Groves, Christopher J. |
  31. Bennett, Amanda J. |
  32. Lehtimäki, Terho |
  33. Viikari, Jorma S. |
  34. Rung, Johan |
  35. Lyssenko, Valeriya |
  36. Perola, Markus |
  37. Heid, Iris M. |
  38. Herder, Christian |
  39. Grallert, Harald |
  40. Müller-Nurasyid, Martina |
  41. Hypponen, Elina |
  42. Roden, Michael |
  43. Isaacs, Aaron |
  44. van Leeuwen, Elisabeth M. |
  45. Karssen, Lennart C. |
  46. Mihailov, Evelin |
  47. Houwing-Duistermaat, Jeanine J. |
  48. de Craen, Anton J. M. |
  49. Deelen, Joris |
  50. Havulinna, Aki S. |
  51. Blades, Matthew |
  52. Hengstenberg, Christian |
  53. Erdmann, Jeanette |
  54. Schunkert, Heribert |
  55. Kaprio, Jaakko |
  56. Tobin, Martin D. |
  57. Samani, Nilesh J. |
  58. Lind, Lars |
  59. Salomaa, Veikko |
  60. Lindgren, Cecilia M. |
  61. Slagboom, P. Eline |
  62. Metspalu, Andres |
  63. van Duijn, Cornelia M. |
  64. Eriksson, Johan G. |
  65. Peters, Annette |
  66. Gieger, Christian |
  67. Jula, Antti |
  68. Groop, Leif |
  69. Raitakari, Olli T. |
  70. Power, Chris |
  71. Penninx, Brenda W. J. H. |
  72. de Geus, Eco |
  73. Smit, Johannes H. |
  74. Boomsma, Dorret I. |
  75. Pedersen, Nancy L. |
  76. Ingelsson, Erik |
  77. Thorsteinsdottir, Unnur |
  78. Stefansson, Kari |
  79. Ripatti, Samuli |
  80. Prokopenko, Inga |
  81. McCarthy, Mark I. |
  82. Morris, Andrew P. |
  83. ENGAGE Consortium |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-01
1000 Erschienen in
1000 Quellenangabe
  • 11(7):e1005230
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pgen.1005230 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488845/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005230#sec021 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI) at genome-wide significance, and two for fasting glucose (FG), none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3) and FG (GCK and G6PC2). The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated.
1000 Sacherschließung
lokal Body mass index
lokal Molecular genetics
lokal Quantitative trait loci
lokal Genome-wide association studies
lokal Quality control
lokal Obesity
lokal Genomic signal processing
lokal Meta-analysis
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SG9yaWtvc2hpLCBNb21va28=|https://frl.publisso.de/adhoc/creator/TdOTZ2ksIFJlZWRpaw==|https://frl.publisso.de/adhoc/creator/dmFuIGRlIEJ1bnQsIE1hcnRpam4=|https://frl.publisso.de/adhoc/creator/U3VyYWtrYSwgSWRh|https://frl.publisso.de/adhoc/creator/U2FyaW4sIEFudHRpLVBla2th|https://frl.publisso.de/adhoc/creator/TWFoYWphbiwgQW51Ymhh|https://frl.publisso.de/adhoc/creator/TWFydWxsbywgTGV0aXppYQ==|https://frl.publisso.de/adhoc/creator/VGhvcmxlaWZzc29uLCBHdWRtYXI=|https://frl.publisso.de/adhoc/creator/SMOkZ2csIFNhcmE=|https://frl.publisso.de/adhoc/creator/SG90dGVuZ2EsIEpvdWtlLUphbg==|https://frl.publisso.de/adhoc/creator/TGFkZW52YWxsLCBDbGFlcw==|https://frl.publisso.de/adhoc/creator/UmllZCwgSmFuaW5hIFMu|https://frl.publisso.de/adhoc/creator/V2lua2xlciwgVGhvbWFzIFcu|https://frl.publisso.de/adhoc/creator/V2lsbGVtcywgU2FyYSBNLg==|https://frl.publisso.de/adhoc/creator/UGVydmpha292YSwgTmF0YWxpYQ==|https://frl.publisso.de/adhoc/creator/RXNrbywgVMO1bnU=|https://frl.publisso.de/adhoc/creator/QmVla21hbiwgTWFyaWFu|https://frl.publisso.de/adhoc/creator/TmVsc29uLCBDaHJpc3RvcGhlciBQLg==|https://frl.publisso.de/adhoc/creator/V2lsbGVuYm9yZywgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/V2lsdHNoaXJlLCBTdGV2ZW4=|https://frl.publisso.de/adhoc/creator/RmVycmVpcmEsIFRlcmVzYQ==|https://frl.publisso.de/adhoc/creator/RmVybmFuZGV6LCBKdWFu|https://frl.publisso.de/adhoc/creator/R2F1bHRvbiwgS3lsZSBKLg==|https://frl.publisso.de/adhoc/creator/U3RlaW50aG9yc2RvdHRpciwgVmFsZ2VyZHVy|https://frl.publisso.de/adhoc/creator/SGFtc3RlbiwgQW5kZXJz|https://frl.publisso.de/adhoc/creator/TWFnbnVzc29uLCBQYXRyaWsgSy4gRS4=|https://frl.publisso.de/adhoc/creator/V2lsbGVtc2VuLCBHb25uZWtl|https://frl.publisso.de/adhoc/creator/TWlsYW5lc2NoaSwgWXVyaQ==|https://frl.publisso.de/adhoc/creator/Um9iZXJ0c29uLCBOZWlsIFIu|https://frl.publisso.de/adhoc/creator/R3JvdmVzLCBDaHJpc3RvcGhlciBKLg==|https://frl.publisso.de/adhoc/creator/QmVubmV0dCwgQW1hbmRhIEou|https://frl.publisso.de/adhoc/creator/TGVodGltw6RraSwgVGVyaG8=|https://frl.publisso.de/adhoc/creator/Vmlpa2FyaSwgSm9ybWEgUy4=|https://frl.publisso.de/adhoc/creator/UnVuZywgSm9oYW4=|https://frl.publisso.de/adhoc/creator/THlzc2Vua28sIFZhbGVyaXlh|https://frl.publisso.de/adhoc/creator/UGVyb2xhLCBNYXJrdXM=|https://frl.publisso.de/adhoc/creator/SGVpZCwgSXJpcyBNLg==|http://orcid.org/0000-0002-2050-093X|https://frl.publisso.de/adhoc/creator/R3JhbGxlcnQsIEhhcmFsZA==|https://frl.publisso.de/adhoc/creator/TcO8bGxlci1OdXJhc3lpZCwgTWFydGluYQ==|https://frl.publisso.de/adhoc/creator/SHlwcG9uZW4sIEVsaW5h|http://d-nb.info/gnd/130812773|https://frl.publisso.de/adhoc/creator/SXNhYWNzLCBBYXJvbg==|https://frl.publisso.de/adhoc/creator/dmFuIExlZXV3ZW4sIEVsaXNhYmV0aCBNLg==|https://frl.publisso.de/adhoc/creator/S2Fyc3NlbiwgTGVubmFydCBDLg==|https://frl.publisso.de/adhoc/creator/TWloYWlsb3YsIEV2ZWxpbg==|https://frl.publisso.de/adhoc/creator/SG91d2luZy1EdWlzdGVybWFhdCwgSmVhbmluZSBKLg==|https://frl.publisso.de/adhoc/creator/ZGUgQ3JhZW4sIEFudG9uIEouIE0u|https://frl.publisso.de/adhoc/creator/RGVlbGVuLCBKb3Jpcw==|https://frl.publisso.de/adhoc/creator/SGF2dWxpbm5hLCBBa2kgUy4=|https://frl.publisso.de/adhoc/creator/QmxhZGVzLCBNYXR0aGV3|https://frl.publisso.de/adhoc/creator/SGVuZ3N0ZW5iZXJnLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/RXJkbWFubiwgSmVhbmV0dGU=|https://frl.publisso.de/adhoc/creator/U2NodW5rZXJ0LCBIZXJpYmVydA==|https://frl.publisso.de/adhoc/creator/S2FwcmlvLCBKYWFra28=|https://frl.publisso.de/adhoc/creator/VG9iaW4sIE1hcnRpbiBELg==|https://frl.publisso.de/adhoc/creator/U2FtYW5pLCBOaWxlc2ggSi4=|https://frl.publisso.de/adhoc/creator/TGluZCwgTGFycw==|https://frl.publisso.de/adhoc/creator/U2Fsb21hYSwgVmVpa2tv|https://frl.publisso.de/adhoc/creator/TGluZGdyZW4sIENlY2lsaWEgTS4=|https://frl.publisso.de/adhoc/creator/U2xhZ2Jvb20sIFAuIEVsaW5l|https://frl.publisso.de/adhoc/creator/TWV0c3BhbHUsIEFuZHJlcw==|https://frl.publisso.de/adhoc/creator/dmFuIER1aWpuLCBDb3JuZWxpYSBNLg==|https://frl.publisso.de/adhoc/creator/RXJpa3Nzb24sIEpvaGFuIEcu|https://frl.publisso.de/adhoc/creator/UGV0ZXJzLCBBbm5ldHRl|https://frl.publisso.de/adhoc/creator/R2llZ2VyLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/SnVsYSwgQW50dGk=|https://frl.publisso.de/adhoc/creator/R3Jvb3AsIExlaWY=|https://frl.publisso.de/adhoc/creator/UmFpdGFrYXJpLCBPbGxpIFQu|https://frl.publisso.de/adhoc/creator/UG93ZXIsIENocmlz|https://frl.publisso.de/adhoc/creator/UGVubmlueCwgQnJlbmRhIFcuIEouIEgu|https://frl.publisso.de/adhoc/creator/ZGUgR2V1cywgRWNv|https://frl.publisso.de/adhoc/creator/U21pdCwgSm9oYW5uZXMgSC4=|https://frl.publisso.de/adhoc/creator/Qm9vbXNtYSwgRG9ycmV0IEku|https://frl.publisso.de/adhoc/creator/UGVkZXJzZW4sIE5hbmN5IEwu|https://frl.publisso.de/adhoc/creator/SW5nZWxzc29uLCBFcmlr|https://frl.publisso.de/adhoc/creator/VGhvcnN0ZWluc2RvdHRpciwgVW5udXI=|https://frl.publisso.de/adhoc/creator/U3RlZmFuc3NvbiwgS2FyaQ==|https://frl.publisso.de/adhoc/creator/UmlwYXR0aSwgU2FtdWxp|https://frl.publisso.de/adhoc/creator/UHJva29wZW5rbywgSW5nYQ==|https://frl.publisso.de/adhoc/creator/TWNDYXJ0aHksIE1hcmsgSS4=|https://frl.publisso.de/adhoc/creator/TW9ycmlzLCBBbmRyZXcgUC4=|https://frl.publisso.de/adhoc/creator/RU5HQUdFIENvbnNvcnRpdW0=
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. MRC
  2. Wellcome Trust
  3. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  4. National Institute of Allergy and Infectious Diseases
  5. National Human Genome Research Institute
  6. National Institute of Child Health and Human Development
  7. Juvenile Diabetes Research Foundation International (JDRF)
  8. European Community
  9. BioSHaRE Consortium
  10. Cardiogenics
  11. Novartis
  12. Signe and Ane Gyllenberg Foundation
  13. Swedish Cultural Foundation in Finland
  14. Finnish Diabetes Research Society
  15. the Sigrid Juselius Foundation
  16. Folkhälsan Research Foundation
  17. Foundation for Life and Health in Finland
  18. Jakobstad Hospital
  19. Medical Society of Finland
  20. Närpes Research Foundation
  21. Vasa and Närpes Health centers
  22. European Network for Genetic and Genomic Epidemiology (ENGAGE)
  23. Collarative European Effort to Develop Diabetes Diagnostics
  24. Swedish Research Council
  25. University of Tartu
  26. Estonian Goverment
  27. European Commission
  28. Estonian Research Infrastructure’s Roadmap and through FP7
  29. Wellcome Trust Sanger Institute
  30. National Institute of Alcohol Abuse and Alcoholism
  31. Academy of Finland
  32. Deutsche Forschungsgemeinschaft
  33. German Federal Ministry of Education and Research (BMBF)
  34. British Heart Foundation
  35. National Institute for Health Research (NIHR)
  36. Samfundet Folkhälsan
  37. Juho Vainio Foundation
  38. Novo Nordisk Foundation
  39. Finska Läkaresällskapet
  40. Päivikki and Sakari Sohlberg Foundation
  41. Yrjö Jahnsson Foundation
  42. State of Bavaria
  43. Munich Center of Health Sciences (MC Health)
  44. Ludwig-Maximilians-Universität
  45. Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW)
  46. German Federal Ministry of Health (BMG)
  47. Innovation-Oriented Research Program on Genomics
  48. Centre for Medical Systems Biology
  49. Netherlands Consortium for Healthy Ageing
  50. Netherlands Genomics Initiative
  51. Netherlands Organization for Scientific Research (NWO)
  52. Unilever Colworth
  53. BBMRI-NL, a Research Infrastructure
  54. NHLBI
  55. Medical Research Council
  56. Center for Medical Systems Biology (CMSB; NWO Genomics)
  57. NBIC/BioAssist
  58. Biobanking and Biomolecular Resources Research Infrastructure
  59. VU University’s Institute for Health and Care Research
  60. Neuroscience Campus Amsterdam (NCA)
  61. European Science Foundation ESF
  62. European Science Council
  63. Rutgers University Cell and DNA Repository
  64. Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA)
  65. National Institutes of Health
  66. Foundation for the US National Institutes of Health
  67. NIMH
  68. Dutch Brain Foundation
  69. department of Psychology and Education of the VU University Amsterdam
  70. Swedish Heart-Lung Foundation
  71. Swedish Foundation for Strategic Research
  72. Royal Swedish Academy of Sciences
  73. Swedish Diabetes Foundation
  74. Swedish Society of Medicine
  75. Erasmus Medical Center
  76. Erasmus University, Rotterdam
  77. Netherlands Organization for the Health Research and Development (ZonMw)
  78. Research Institute for Diseases in the Elderly (RIDE)
  79. Ministry of Education, Culture and Science (Netherlands)
  80. Ministry for Health, Welfare and Sports (Netherlands)
  81. Municipality of Rotterdam
  82. Ministry for Higher Education (Sweden)
  83. GenomEUtwin
  84. Uppsala University
  85. Uppsala University Hospital
  86. Social Insurance Institution of Finland, Kuopio
  87. Tampere and Turku University Hospital Medical Funds
  88. Paavo Nurmi Foundation
  89. Finnish Foundation of Cardiovascular Research (TL, OTR)
  90. Finnish Cultural Foundation
  91. Tampere Tuberculosis Foundation
  92. Emil Aaltonen Foundation
  93. Manpei Suzuki Diabetes Foundation
  94. Helsinki University Doctoral Programme in Biomedicine (DPBM)
  95. University of Ferrara – Holder: Prof. Guido Barbujani
  96. German National Genome Research Network
  97. CARDomics
1000 Fördernummer
  1. G0000934
  2. 068545/Z/02; 076113; GR069224; 098381; WT098017; WT090532; WT064890
  3. -
  4. -
  5. -
  6. -
  7. U01 DK062418
  8. FP7/2007-2013; FP7/2007-2011: 259679; HEALTH-F2-2008-200647
  9. 261433
  10. LSHM-CT-2006-037593
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. HEALTH-F4-2007- 201413
  23. CEED/2008-2012
  24. 31475113580; M-2005-1112; 2009-2298
  25. -
  26. SF0180142s08
  27. -
  28. 313010
  29. -
  30. AA-12502; AA-00145; AA-09203; AA15416; K02AA018755
  31. 100499; 205585; 118555; 141054; 265240; 263278; 264146; 114382; 126775; 127437; 129255; 129306; 130326; 209072; 210595; 213225; 216374; 134309; 126925; 121584; 124282; 129378; 117787; 41071; 139635; 129494; 213506; 129680; 251217
  32. -
  33. -
  34. -
  35. -
  36. -
  37. -
  38. -
  39. -
  40. -
  41. -
  42. -
  43. -
  44. NGFNPLUS 01GS0823
  45. -
  46. -
  47. IGE05007
  48. -
  49. 050-060-810
  50. -
  51. 904-61-090; 985-10-002;904-61-193;480-04-004; 400-05-717; 31160008; 911-09-032; 56-464-14192; 10-000-1002; 480- 05-003; 175.010.2005.011; 911-03-012; 050-060-810
  52. -
  53. -
  54. 1RL1MH083268-01
  55. G0500539; G0600705
  56. -
  57. RK(2008.024)
  58. BBMRI –NL, 184.021.007
  59. -
  60. -
  61. EU/QLRT-2001-01254
  62. 230374
  63. NIMH U24 MH068457-06
  64. -
  65. NIH, R01D0042157-01A; DK U01-066134
  66. -
  67. 1RC2MH089951-0; 1RC2 MH089995-01
  68. -
  69. -
  70. -
  71. SSF; ICA08-0047
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. -
  81. -
  82. -
  83. EU/QLRT-2001-01254; QLG2-CT-2002-01254
  84. -
  85. -
  86. -
  87. 9M048; 9N035
  88. -
  89. -
  90. -
  91. -
  92. -
  93. -
  94. -
  95. -
  96. -
  97. 01KU0908A
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. Seventh Framework Programme
  9. -
  10. -
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. -
  23. -
  24. Linné
  25. Center of Translational Genomics
  26. Genomic, metabolic and demographic characteristics of type 2 diabetes in the Estonian population
  27. Centre of Excellence in Genomics
  28. -
  29. -
  30. -
  31. -
  32. -
  33. -
  34. -
  35. Leicester Cardiovascular Biomedical Research Unit
  36. -
  37. -
  38. -
  39. -
  40. -
  41. -
  42. -
  43. -
  44. LMUinnovativ
  45. -
  46. -
  47. SenterNovem
  48. -
  49. -
  50. -
  51. -
  52. -
  53. -
  54. STAMPEED program
  55. -
  56. -
  57. -
  58. -
  59. -
  60. -
  61. -
  62. ERC Advanced
  63. -
  64. -
  65. -
  66. -
  67. Grand Opportunity
  68. -
  69. -
  70. -
  71. -
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. -
  81. -
  82. -
  83. -
  84. -
  85. -
  86. -
  87. TeLeht
  88. -
  89. -
  90. -
  91. -
  92. -
  93. -
  94. -
  95. -
  96. NGFN-2; NGFN-plus
  97. -
1000 Dateien
  1. Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408564.rdf
1000 Erstellt am 2018-06-27T12:45:04.414+0200
1000 Erstellt von 218
1000 beschreibt frl:6408564
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2020-01-30T19:01:33.845+0100
1000 Objekt bearb. Tue Sep 04 10:29:43 CEST 2018
1000 Vgl. frl:6408564
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408564 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source