Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

  1. Horikoshi, Momoko
  2. Mӓgi, Reedik
  3. van de Bunt, Martijn
  4. Surakka, Ida
  5. Sarin, Antti-Pekka
  6. Mahajan, Anubha
  7. Marullo, Letizia
  8. Thorleifsson, Gudmar
  9. Hägg, Sara
  10. Hottenga, Jouke-Jan
  11. Ladenvall, Claes
  12. Ried, Janina S.
  13. Winkler, Thomas W.
  14. Willems, Sara M.
  15. Pervjakova, Natalia
  16. Esko, Tõnu
  17. Beekman, Marian
  18. Nelson, Christopher P.
  19. Willenborg, Christina
  20. Wiltshire, Steven
  21. Ferreira, Teresa
  22. Fernandez, Juan
  23. Gaulton, Kyle J.
  24. Steinthorsdottir, Valgerdur
  25. Hamsten, Anders
  26. Magnusson, Patrik K. E.
  27. Willemsen, Gonneke
  28. Milaneschi, Yuri
  29. Robertson, Neil R.
  30. Groves, Christopher J.
  31. Bennett, Amanda J.
  32. Lehtimäki, Terho
  33. Viikari, Jorma S.
  34. Rung, Johan
  35. Lyssenko, Valeriya
  36. Perola, Markus
  37. Heid, Iris M.
  38. Herder, Christian ORCID logo
  39. Grallert, Harald
  40. Müller-Nurasyid, Martina
  41. Hypponen, Elina
  42. Roden, Michael
  43. Isaacs, Aaron
  44. van Leeuwen, Elisabeth M.
  45. Karssen, Lennart C.
  46. Mihailov, Evelin
  47. Houwing-Duistermaat, Jeanine J.
  48. de Craen, Anton J. M.
  49. Deelen, Joris
  50. Havulinna, Aki S.
  51. Blades, Matthew
  52. Hengstenberg, Christian
  53. Erdmann, Jeanette
  54. Schunkert, Heribert
  55. Kaprio, Jaakko
  56. Tobin, Martin D.
  57. Samani, Nilesh J.
  58. Lind, Lars
  59. Salomaa, Veikko
  60. Lindgren, Cecilia M.
  61. Slagboom, P. Eline
  62. Metspalu, Andres
  63. van Duijn, Cornelia M.
  64. Eriksson, Johan G.
  65. Peters, Annette
  66. Gieger, Christian
  67. Jula, Antti
  68. Groop, Leif
  69. Raitakari, Olli T.
  70. Power, Chris
  71. Penninx, Brenda W. J. H.
  72. de Geus, Eco
  73. Smit, Johannes H.
  74. Boomsma, Dorret I.
  75. Pedersen, Nancy L.
  76. Ingelsson, Erik
  77. Thorsteinsdottir, Unnur
  78. Stefansson, Kari
  79. Ripatti, Samuli
  80. Prokopenko, Inga
  81. McCarthy, Mark I.
  82. Morris, Andrew P.
  83. ENGAGE Consortium

Download
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.pdf 2,12MB
WeightNameValue
1000 Titel
  • Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
1000 Autor/in
  1. Horikoshi, Momoko |
  2. Mӓgi, Reedik |
  3. van de Bunt, Martijn |
  4. Surakka, Ida |
  5. Sarin, Antti-Pekka |
  6. Mahajan, Anubha |
  7. Marullo, Letizia |
  8. Thorleifsson, Gudmar |
  9. Hägg, Sara |
  10. Hottenga, Jouke-Jan |
  11. Ladenvall, Claes |
  12. Ried, Janina S. |
  13. Winkler, Thomas W. |
  14. Willems, Sara M. |
  15. Pervjakova, Natalia |
  16. Esko, Tõnu |
  17. Beekman, Marian |
  18. Nelson, Christopher P. |
  19. Willenborg, Christina |
  20. Wiltshire, Steven |
  21. Ferreira, Teresa |
  22. Fernandez, Juan |
  23. Gaulton, Kyle J. |
  24. Steinthorsdottir, Valgerdur |
  25. Hamsten, Anders |
  26. Magnusson, Patrik K. E. |
  27. Willemsen, Gonneke |
  28. Milaneschi, Yuri |
  29. Robertson, Neil R. |
  30. Groves, Christopher J. |
  31. Bennett, Amanda J. |
  32. Lehtimäki, Terho |
  33. Viikari, Jorma S. |
  34. Rung, Johan |
  35. Lyssenko, Valeriya |
  36. Perola, Markus |
  37. Heid, Iris M. |
  38. Herder, Christian |
  39. Grallert, Harald |
  40. Müller-Nurasyid, Martina |
  41. Hypponen, Elina |
  42. Roden, Michael |
  43. Isaacs, Aaron |
  44. van Leeuwen, Elisabeth M. |
  45. Karssen, Lennart C. |
  46. Mihailov, Evelin |
  47. Houwing-Duistermaat, Jeanine J. |
  48. de Craen, Anton J. M. |
  49. Deelen, Joris |
  50. Havulinna, Aki S. |
  51. Blades, Matthew |
  52. Hengstenberg, Christian |
  53. Erdmann, Jeanette |
  54. Schunkert, Heribert |
  55. Kaprio, Jaakko |
  56. Tobin, Martin D. |
  57. Samani, Nilesh J. |
  58. Lind, Lars |
  59. Salomaa, Veikko |
  60. Lindgren, Cecilia M. |
  61. Slagboom, P. Eline |
  62. Metspalu, Andres |
  63. van Duijn, Cornelia M. |
  64. Eriksson, Johan G. |
  65. Peters, Annette |
  66. Gieger, Christian |
  67. Jula, Antti |
  68. Groop, Leif |
  69. Raitakari, Olli T. |
  70. Power, Chris |
  71. Penninx, Brenda W. J. H. |
  72. de Geus, Eco |
  73. Smit, Johannes H. |
  74. Boomsma, Dorret I. |
  75. Pedersen, Nancy L. |
  76. Ingelsson, Erik |
  77. Thorsteinsdottir, Unnur |
  78. Stefansson, Kari |
  79. Ripatti, Samuli |
  80. Prokopenko, Inga |
  81. McCarthy, Mark I. |
  82. Morris, Andrew P. |
  83. ENGAGE Consortium |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-01
1000 Erschienen in
1000 Quellenangabe
  • 11(7):e1005230
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pgen.1005230 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488845/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005230#sec021 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI) at genome-wide significance, and two for fasting glucose (FG), none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3) and FG (GCK and G6PC2). The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated.
1000 Sacherschließung
lokal Body mass index
lokal Molecular genetics
lokal Quantitative trait loci
lokal Genome-wide association studies
lokal Quality control
lokal Obesity
lokal Genomic signal processing
lokal Meta-analysis
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SG9yaWtvc2hpLCBNb21va28=|https://frl.publisso.de/adhoc/creator/TdOTZ2ksIFJlZWRpaw==|https://frl.publisso.de/adhoc/creator/dmFuIGRlIEJ1bnQsIE1hcnRpam4=|https://frl.publisso.de/adhoc/creator/U3VyYWtrYSwgSWRh|https://frl.publisso.de/adhoc/creator/U2FyaW4sIEFudHRpLVBla2th|https://frl.publisso.de/adhoc/creator/TWFoYWphbiwgQW51Ymhh|https://frl.publisso.de/adhoc/creator/TWFydWxsbywgTGV0aXppYQ==|https://frl.publisso.de/adhoc/creator/VGhvcmxlaWZzc29uLCBHdWRtYXI=|https://frl.publisso.de/adhoc/creator/SMOkZ2csIFNhcmE=|https://frl.publisso.de/adhoc/creator/SG90dGVuZ2EsIEpvdWtlLUphbg==|https://frl.publisso.de/adhoc/creator/TGFkZW52YWxsLCBDbGFlcw==|https://frl.publisso.de/adhoc/creator/UmllZCwgSmFuaW5hIFMu|https://frl.publisso.de/adhoc/creator/V2lua2xlciwgVGhvbWFzIFcu|https://frl.publisso.de/adhoc/creator/V2lsbGVtcywgU2FyYSBNLg==|https://frl.publisso.de/adhoc/creator/UGVydmpha292YSwgTmF0YWxpYQ==|https://frl.publisso.de/adhoc/creator/RXNrbywgVMO1bnU=|https://frl.publisso.de/adhoc/creator/QmVla21hbiwgTWFyaWFu|https://frl.publisso.de/adhoc/creator/TmVsc29uLCBDaHJpc3RvcGhlciBQLg==|https://frl.publisso.de/adhoc/creator/V2lsbGVuYm9yZywgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/V2lsdHNoaXJlLCBTdGV2ZW4=|https://frl.publisso.de/adhoc/creator/RmVycmVpcmEsIFRlcmVzYQ==|https://frl.publisso.de/adhoc/creator/RmVybmFuZGV6LCBKdWFu|https://frl.publisso.de/adhoc/creator/R2F1bHRvbiwgS3lsZSBKLg==|https://frl.publisso.de/adhoc/creator/U3RlaW50aG9yc2RvdHRpciwgVmFsZ2VyZHVy|https://frl.publisso.de/adhoc/creator/SGFtc3RlbiwgQW5kZXJz|https://frl.publisso.de/adhoc/creator/TWFnbnVzc29uLCBQYXRyaWsgSy4gRS4=|https://frl.publisso.de/adhoc/creator/V2lsbGVtc2VuLCBHb25uZWtl|https://frl.publisso.de/adhoc/creator/TWlsYW5lc2NoaSwgWXVyaQ==|https://frl.publisso.de/adhoc/creator/Um9iZXJ0c29uLCBOZWlsIFIu|https://frl.publisso.de/adhoc/creator/R3JvdmVzLCBDaHJpc3RvcGhlciBKLg==|https://frl.publisso.de/adhoc/creator/QmVubmV0dCwgQW1hbmRhIEou|https://frl.publisso.de/adhoc/creator/TGVodGltw6RraSwgVGVyaG8=|https://frl.publisso.de/adhoc/creator/Vmlpa2FyaSwgSm9ybWEgUy4=|https://frl.publisso.de/adhoc/creator/UnVuZywgSm9oYW4=|https://frl.publisso.de/adhoc/creator/THlzc2Vua28sIFZhbGVyaXlh|https://frl.publisso.de/adhoc/creator/UGVyb2xhLCBNYXJrdXM=|https://frl.publisso.de/adhoc/creator/SGVpZCwgSXJpcyBNLg==|http://orcid.org/0000-0002-2050-093X|https://frl.publisso.de/adhoc/creator/R3JhbGxlcnQsIEhhcmFsZA==|https://frl.publisso.de/adhoc/creator/TcO8bGxlci1OdXJhc3lpZCwgTWFydGluYQ==|https://frl.publisso.de/adhoc/creator/SHlwcG9uZW4sIEVsaW5h|http://d-nb.info/gnd/130812773|https://frl.publisso.de/adhoc/creator/SXNhYWNzLCBBYXJvbg==|https://frl.publisso.de/adhoc/creator/dmFuIExlZXV3ZW4sIEVsaXNhYmV0aCBNLg==|https://frl.publisso.de/adhoc/creator/S2Fyc3NlbiwgTGVubmFydCBDLg==|https://frl.publisso.de/adhoc/creator/TWloYWlsb3YsIEV2ZWxpbg==|https://frl.publisso.de/adhoc/creator/SG91d2luZy1EdWlzdGVybWFhdCwgSmVhbmluZSBKLg==|https://frl.publisso.de/adhoc/creator/ZGUgQ3JhZW4sIEFudG9uIEouIE0u|https://frl.publisso.de/adhoc/creator/RGVlbGVuLCBKb3Jpcw==|https://frl.publisso.de/adhoc/creator/SGF2dWxpbm5hLCBBa2kgUy4=|https://frl.publisso.de/adhoc/creator/QmxhZGVzLCBNYXR0aGV3|https://frl.publisso.de/adhoc/creator/SGVuZ3N0ZW5iZXJnLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/RXJkbWFubiwgSmVhbmV0dGU=|https://frl.publisso.de/adhoc/creator/U2NodW5rZXJ0LCBIZXJpYmVydA==|https://frl.publisso.de/adhoc/creator/S2FwcmlvLCBKYWFra28=|https://frl.publisso.de/adhoc/creator/VG9iaW4sIE1hcnRpbiBELg==|https://frl.publisso.de/adhoc/creator/U2FtYW5pLCBOaWxlc2ggSi4=|https://frl.publisso.de/adhoc/creator/TGluZCwgTGFycw==|https://frl.publisso.de/adhoc/creator/U2Fsb21hYSwgVmVpa2tv|https://frl.publisso.de/adhoc/creator/TGluZGdyZW4sIENlY2lsaWEgTS4=|https://frl.publisso.de/adhoc/creator/U2xhZ2Jvb20sIFAuIEVsaW5l|https://frl.publisso.de/adhoc/creator/TWV0c3BhbHUsIEFuZHJlcw==|https://frl.publisso.de/adhoc/creator/dmFuIER1aWpuLCBDb3JuZWxpYSBNLg==|https://frl.publisso.de/adhoc/creator/RXJpa3Nzb24sIEpvaGFuIEcu|https://frl.publisso.de/adhoc/creator/UGV0ZXJzLCBBbm5ldHRl|https://frl.publisso.de/adhoc/creator/R2llZ2VyLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/SnVsYSwgQW50dGk=|https://frl.publisso.de/adhoc/creator/R3Jvb3AsIExlaWY=|https://frl.publisso.de/adhoc/creator/UmFpdGFrYXJpLCBPbGxpIFQu|https://frl.publisso.de/adhoc/creator/UG93ZXIsIENocmlz|https://frl.publisso.de/adhoc/creator/UGVubmlueCwgQnJlbmRhIFcuIEouIEgu|https://frl.publisso.de/adhoc/creator/ZGUgR2V1cywgRWNv|https://frl.publisso.de/adhoc/creator/U21pdCwgSm9oYW5uZXMgSC4=|https://frl.publisso.de/adhoc/creator/Qm9vbXNtYSwgRG9ycmV0IEku|https://frl.publisso.de/adhoc/creator/UGVkZXJzZW4sIE5hbmN5IEwu|https://frl.publisso.de/adhoc/creator/SW5nZWxzc29uLCBFcmlr|https://frl.publisso.de/adhoc/creator/VGhvcnN0ZWluc2RvdHRpciwgVW5udXI=|https://frl.publisso.de/adhoc/creator/U3RlZmFuc3NvbiwgS2FyaQ==|https://frl.publisso.de/adhoc/creator/UmlwYXR0aSwgU2FtdWxp|https://frl.publisso.de/adhoc/creator/UHJva29wZW5rbywgSW5nYQ==|https://frl.publisso.de/adhoc/creator/TWNDYXJ0aHksIE1hcmsgSS4=|https://frl.publisso.de/adhoc/creator/TW9ycmlzLCBBbmRyZXcgUC4=|https://frl.publisso.de/adhoc/creator/RU5HQUdFIENvbnNvcnRpdW0=
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. MRC |
  2. Wellcome Trust |
  3. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
  4. National Institute of Allergy and Infectious Diseases |
  5. National Human Genome Research Institute |
  6. National Institute of Child Health and Human Development |
  7. Juvenile Diabetes Research Foundation International (JDRF) |
  8. European Community |
  9. BioSHaRE Consortium |
  10. Cardiogenics |
  11. Novartis |
  12. Signe and Ane Gyllenberg Foundation |
  13. Swedish Cultural Foundation in Finland |
  14. Finnish Diabetes Research Society |
  15. the Sigrid Juselius Foundation |
  16. Folkhälsan Research Foundation |
  17. Foundation for Life and Health in Finland |
  18. Jakobstad Hospital |
  19. Medical Society of Finland |
  20. Närpes Research Foundation |
  21. Vasa and Närpes Health centers |
  22. European Network for Genetic and Genomic Epidemiology (ENGAGE) |
  23. Collarative European Effort to Develop Diabetes Diagnostics |
  24. Swedish Research Council |
  25. University of Tartu |
  26. Estonian Goverment |
  27. European Commission |
  28. Estonian Research Infrastructure’s Roadmap and through FP7 |
  29. Wellcome Trust Sanger Institute |
  30. National Institute of Alcohol Abuse and Alcoholism |
  31. Academy of Finland |
  32. Deutsche Forschungsgemeinschaft |
  33. German Federal Ministry of Education and Research (BMBF) |
  34. British Heart Foundation |
  35. National Institute for Health Research (NIHR) |
  36. Samfundet Folkhälsan |
  37. Juho Vainio Foundation |
  38. Novo Nordisk Foundation |
  39. Finska Läkaresällskapet |
  40. Päivikki and Sakari Sohlberg Foundation |
  41. Yrjö Jahnsson Foundation |
  42. State of Bavaria |
  43. Munich Center of Health Sciences (MC Health) |
  44. Ludwig-Maximilians-Universität |
  45. Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW) |
  46. German Federal Ministry of Health (BMG) |
  47. Innovation-Oriented Research Program on Genomics |
  48. Centre for Medical Systems Biology |
  49. Netherlands Consortium for Healthy Ageing |
  50. Netherlands Genomics Initiative |
  51. Netherlands Organization for Scientific Research (NWO) |
  52. Unilever Colworth |
  53. BBMRI-NL, a Research Infrastructure |
  54. NHLBI |
  55. Medical Research Council |
  56. Center for Medical Systems Biology (CMSB; NWO Genomics) |
  57. NBIC/BioAssist |
  58. Biobanking and Biomolecular Resources Research Infrastructure |
  59. VU University’s Institute for Health and Care Research |
  60. Neuroscience Campus Amsterdam (NCA) |
  61. European Science Foundation ESF |
  62. European Science Council |
  63. Rutgers University Cell and DNA Repository |
  64. Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA) |
  65. National Institutes of Health |
  66. Foundation for the US National Institutes of Health |
  67. NIMH |
  68. Dutch Brain Foundation |
  69. department of Psychology and Education of the VU University Amsterdam |
  70. Swedish Heart-Lung Foundation |
  71. Swedish Foundation for Strategic Research |
  72. Royal Swedish Academy of Sciences |
  73. Swedish Diabetes Foundation |
  74. Swedish Society of Medicine |
  75. Erasmus Medical Center |
  76. Erasmus University, Rotterdam |
  77. Netherlands Organization for the Health Research and Development (ZonMw) |
  78. Research Institute for Diseases in the Elderly (RIDE) |
  79. Ministry of Education, Culture and Science (Netherlands) |
  80. Ministry for Health, Welfare and Sports (Netherlands) |
  81. Municipality of Rotterdam |
  82. Ministry for Higher Education (Sweden) |
  83. GenomEUtwin |
  84. Uppsala University |
  85. Uppsala University Hospital |
  86. Social Insurance Institution of Finland, Kuopio |
  87. Tampere and Turku University Hospital Medical Funds |
  88. Paavo Nurmi Foundation |
  89. Finnish Foundation of Cardiovascular Research (TL, OTR) |
  90. Finnish Cultural Foundation |
  91. Tampere Tuberculosis Foundation |
  92. Emil Aaltonen Foundation |
  93. Manpei Suzuki Diabetes Foundation |
  94. Helsinki University Doctoral Programme in Biomedicine (DPBM) |
  95. University of Ferrara – Holder: Prof. Guido Barbujani |
  96. German National Genome Research Network |
  97. CARDomics |
1000 Fördernummer
  1. G0000934
  2. 068545/Z/02; 076113; GR069224; 098381; WT098017; WT090532; WT064890
  3. -
  4. -
  5. -
  6. -
  7. U01 DK062418
  8. FP7/2007-2013; FP7/2007-2011: 259679; HEALTH-F2-2008-200647
  9. 261433
  10. LSHM-CT-2006-037593
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. HEALTH-F4-2007- 201413
  23. CEED/2008-2012
  24. 31475113580; M-2005-1112; 2009-2298
  25. -
  26. SF0180142s08
  27. -
  28. 313010
  29. -
  30. AA-12502; AA-00145; AA-09203; AA15416; K02AA018755
  31. 100499; 205585; 118555; 141054; 265240; 263278; 264146; 114382; 126775; 127437; 129255; 129306; 130326; 209072; 210595; 213225; 216374; 134309; 126925; 121584; 124282; 129378; 117787; 41071; 139635; 129494; 213506; 129680; 251217
  32. -
  33. -
  34. -
  35. -
  36. -
  37. -
  38. -
  39. -
  40. -
  41. -
  42. -
  43. -
  44. NGFNPLUS 01GS0823
  45. -
  46. -
  47. IGE05007
  48. -
  49. 050-060-810
  50. -
  51. 904-61-090; 985-10-002;904-61-193;480-04-004; 400-05-717; 31160008; 911-09-032; 56-464-14192; 10-000-1002; 480- 05-003; 175.010.2005.011; 911-03-012; 050-060-810
  52. -
  53. -
  54. 1RL1MH083268-01
  55. G0500539; G0600705
  56. -
  57. RK(2008.024)
  58. BBMRI –NL, 184.021.007
  59. -
  60. -
  61. EU/QLRT-2001-01254
  62. 230374
  63. NIMH U24 MH068457-06
  64. -
  65. NIH, R01D0042157-01A; DK U01-066134
  66. -
  67. 1RC2MH089951-0; 1RC2 MH089995-01
  68. -
  69. -
  70. -
  71. SSF; ICA08-0047
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. -
  81. -
  82. -
  83. EU/QLRT-2001-01254; QLG2-CT-2002-01254
  84. -
  85. -
  86. -
  87. 9M048; 9N035
  88. -
  89. -
  90. -
  91. -
  92. -
  93. -
  94. -
  95. -
  96. -
  97. 01KU0908A
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. Seventh Framework Programme
  9. -
  10. -
  11. -
  12. -
  13. -
  14. -
  15. -
  16. -
  17. -
  18. -
  19. -
  20. -
  21. -
  22. -
  23. -
  24. Linné
  25. Center of Translational Genomics
  26. Genomic, metabolic and demographic characteristics of type 2 diabetes in the Estonian population
  27. Centre of Excellence in Genomics
  28. -
  29. -
  30. -
  31. -
  32. -
  33. -
  34. -
  35. Leicester Cardiovascular Biomedical Research Unit
  36. -
  37. -
  38. -
  39. -
  40. -
  41. -
  42. -
  43. -
  44. LMUinnovativ
  45. -
  46. -
  47. SenterNovem
  48. -
  49. -
  50. -
  51. -
  52. -
  53. -
  54. STAMPEED program
  55. -
  56. -
  57. -
  58. -
  59. -
  60. -
  61. -
  62. ERC Advanced
  63. -
  64. -
  65. -
  66. -
  67. Grand Opportunity
  68. -
  69. -
  70. -
  71. -
  72. -
  73. -
  74. -
  75. -
  76. -
  77. -
  78. -
  79. -
  80. -
  81. -
  82. -
  83. -
  84. -
  85. -
  86. -
  87. TeLeht
  88. -
  89. -
  90. -
  91. -
  92. -
  93. -
  94. -
  95. -
  96. NGFN-2; NGFN-plus
  97. -
1000 Dateien
  1. Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer MRC |
    1000 Förderprogramm -
    1000 Fördernummer G0000934
  2. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm -
    1000 Fördernummer 068545/Z/02; 076113; GR069224; 098381; WT098017; WT090532; WT064890
  3. 1000 joinedFunding-child
    1000 Förderer National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer National Institute of Allergy and Infectious Diseases |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer National Human Genome Research Institute |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer National Institute of Child Health and Human Development |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer Juvenile Diabetes Research Foundation International (JDRF) |
    1000 Förderprogramm -
    1000 Fördernummer U01 DK062418
  8. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Seventh Framework Programme
    1000 Fördernummer FP7/2007-2013; FP7/2007-2011: 259679; HEALTH-F2-2008-200647
  9. 1000 joinedFunding-child
    1000 Förderer BioSHaRE Consortium |
    1000 Förderprogramm -
    1000 Fördernummer 261433
  10. 1000 joinedFunding-child
    1000 Förderer Cardiogenics |
    1000 Förderprogramm -
    1000 Fördernummer LSHM-CT-2006-037593
  11. 1000 joinedFunding-child
    1000 Förderer Novartis |
    1000 Förderprogramm -
    1000 Fördernummer -
  12. 1000 joinedFunding-child
    1000 Förderer Signe and Ane Gyllenberg Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  13. 1000 joinedFunding-child
    1000 Förderer Swedish Cultural Foundation in Finland |
    1000 Förderprogramm -
    1000 Fördernummer -
  14. 1000 joinedFunding-child
    1000 Förderer Finnish Diabetes Research Society |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer the Sigrid Juselius Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  16. 1000 joinedFunding-child
    1000 Förderer Folkhälsan Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer Foundation for Life and Health in Finland |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer Jakobstad Hospital |
    1000 Förderprogramm -
    1000 Fördernummer -
  19. 1000 joinedFunding-child
    1000 Förderer Medical Society of Finland |
    1000 Förderprogramm -
    1000 Fördernummer -
  20. 1000 joinedFunding-child
    1000 Förderer Närpes Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  21. 1000 joinedFunding-child
    1000 Förderer Vasa and Närpes Health centers |
    1000 Förderprogramm -
    1000 Fördernummer -
  22. 1000 joinedFunding-child
    1000 Förderer European Network for Genetic and Genomic Epidemiology (ENGAGE) |
    1000 Förderprogramm -
    1000 Fördernummer HEALTH-F4-2007- 201413
  23. 1000 joinedFunding-child
    1000 Förderer Collarative European Effort to Develop Diabetes Diagnostics |
    1000 Förderprogramm -
    1000 Fördernummer CEED/2008-2012
  24. 1000 joinedFunding-child
    1000 Förderer Swedish Research Council |
    1000 Förderprogramm Linné
    1000 Fördernummer 31475113580; M-2005-1112; 2009-2298
  25. 1000 joinedFunding-child
    1000 Förderer University of Tartu |
    1000 Förderprogramm Center of Translational Genomics
    1000 Fördernummer -
  26. 1000 joinedFunding-child
    1000 Förderer Estonian Goverment |
    1000 Förderprogramm Genomic, metabolic and demographic characteristics of type 2 diabetes in the Estonian population
    1000 Fördernummer SF0180142s08
  27. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Centre of Excellence in Genomics
    1000 Fördernummer -
  28. 1000 joinedFunding-child
    1000 Förderer Estonian Research Infrastructure’s Roadmap and through FP7 |
    1000 Förderprogramm -
    1000 Fördernummer 313010
  29. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust Sanger Institute |
    1000 Förderprogramm -
    1000 Fördernummer -
  30. 1000 joinedFunding-child
    1000 Förderer National Institute of Alcohol Abuse and Alcoholism |
    1000 Förderprogramm -
    1000 Fördernummer AA-12502; AA-00145; AA-09203; AA15416; K02AA018755
  31. 1000 joinedFunding-child
    1000 Förderer Academy of Finland |
    1000 Förderprogramm -
    1000 Fördernummer 100499; 205585; 118555; 141054; 265240; 263278; 264146; 114382; 126775; 127437; 129255; 129306; 130326; 209072; 210595; 213225; 216374; 134309; 126925; 121584; 124282; 129378; 117787; 41071; 139635; 129494; 213506; 129680; 251217
  32. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
  33. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  34. 1000 joinedFunding-child
    1000 Förderer British Heart Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  35. 1000 joinedFunding-child
    1000 Förderer National Institute for Health Research (NIHR) |
    1000 Förderprogramm Leicester Cardiovascular Biomedical Research Unit
    1000 Fördernummer -
  36. 1000 joinedFunding-child
    1000 Förderer Samfundet Folkhälsan |
    1000 Förderprogramm -
    1000 Fördernummer -
  37. 1000 joinedFunding-child
    1000 Förderer Juho Vainio Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  38. 1000 joinedFunding-child
    1000 Förderer Novo Nordisk Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  39. 1000 joinedFunding-child
    1000 Förderer Finska Läkaresällskapet |
    1000 Förderprogramm -
    1000 Fördernummer -
  40. 1000 joinedFunding-child
    1000 Förderer Päivikki and Sakari Sohlberg Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  41. 1000 joinedFunding-child
    1000 Förderer Yrjö Jahnsson Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  42. 1000 joinedFunding-child
    1000 Förderer State of Bavaria |
    1000 Förderprogramm -
    1000 Fördernummer -
  43. 1000 joinedFunding-child
    1000 Förderer Munich Center of Health Sciences (MC Health) |
    1000 Förderprogramm -
    1000 Fördernummer -
  44. 1000 joinedFunding-child
    1000 Förderer Ludwig-Maximilians-Universität |
    1000 Förderprogramm LMUinnovativ
    1000 Fördernummer NGFNPLUS 01GS0823
  45. 1000 joinedFunding-child
    1000 Förderer Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW) |
    1000 Förderprogramm -
    1000 Fördernummer -
  46. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Health (BMG) |
    1000 Förderprogramm -
    1000 Fördernummer -
  47. 1000 joinedFunding-child
    1000 Förderer Innovation-Oriented Research Program on Genomics |
    1000 Förderprogramm SenterNovem
    1000 Fördernummer IGE05007
  48. 1000 joinedFunding-child
    1000 Förderer Centre for Medical Systems Biology |
    1000 Förderprogramm -
    1000 Fördernummer -
  49. 1000 joinedFunding-child
    1000 Förderer Netherlands Consortium for Healthy Ageing |
    1000 Förderprogramm -
    1000 Fördernummer 050-060-810
  50. 1000 joinedFunding-child
    1000 Förderer Netherlands Genomics Initiative |
    1000 Förderprogramm -
    1000 Fördernummer -
  51. 1000 joinedFunding-child
    1000 Förderer Netherlands Organization for Scientific Research (NWO) |
    1000 Förderprogramm -
    1000 Fördernummer 904-61-090; 985-10-002;904-61-193;480-04-004; 400-05-717; 31160008; 911-09-032; 56-464-14192; 10-000-1002; 480- 05-003; 175.010.2005.011; 911-03-012; 050-060-810
  52. 1000 joinedFunding-child
    1000 Förderer Unilever Colworth |
    1000 Förderprogramm -
    1000 Fördernummer -
  53. 1000 joinedFunding-child
    1000 Förderer BBMRI-NL, a Research Infrastructure |
    1000 Förderprogramm -
    1000 Fördernummer -
  54. 1000 joinedFunding-child
    1000 Förderer NHLBI |
    1000 Förderprogramm STAMPEED program
    1000 Fördernummer 1RL1MH083268-01
  55. 1000 joinedFunding-child
    1000 Förderer Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer G0500539; G0600705
  56. 1000 joinedFunding-child
    1000 Förderer Center for Medical Systems Biology (CMSB; NWO Genomics) |
    1000 Förderprogramm -
    1000 Fördernummer -
  57. 1000 joinedFunding-child
    1000 Förderer NBIC/BioAssist |
    1000 Förderprogramm -
    1000 Fördernummer RK(2008.024)
  58. 1000 joinedFunding-child
    1000 Förderer Biobanking and Biomolecular Resources Research Infrastructure |
    1000 Förderprogramm -
    1000 Fördernummer BBMRI –NL, 184.021.007
  59. 1000 joinedFunding-child
    1000 Förderer VU University’s Institute for Health and Care Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  60. 1000 joinedFunding-child
    1000 Förderer Neuroscience Campus Amsterdam (NCA) |
    1000 Förderprogramm -
    1000 Fördernummer -
  61. 1000 joinedFunding-child
    1000 Förderer European Science Foundation ESF |
    1000 Förderprogramm -
    1000 Fördernummer EU/QLRT-2001-01254
  62. 1000 joinedFunding-child
    1000 Förderer European Science Council |
    1000 Förderprogramm ERC Advanced
    1000 Fördernummer 230374
  63. 1000 joinedFunding-child
    1000 Förderer Rutgers University Cell and DNA Repository |
    1000 Förderprogramm -
    1000 Fördernummer NIMH U24 MH068457-06
  64. 1000 joinedFunding-child
    1000 Förderer Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA) |
    1000 Förderprogramm -
    1000 Fördernummer -
  65. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer NIH, R01D0042157-01A; DK U01-066134
  66. 1000 joinedFunding-child
    1000 Förderer Foundation for the US National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  67. 1000 joinedFunding-child
    1000 Förderer NIMH |
    1000 Förderprogramm Grand Opportunity
    1000 Fördernummer 1RC2MH089951-0; 1RC2 MH089995-01
  68. 1000 joinedFunding-child
    1000 Förderer Dutch Brain Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  69. 1000 joinedFunding-child
    1000 Förderer department of Psychology and Education of the VU University Amsterdam |
    1000 Förderprogramm -
    1000 Fördernummer -
  70. 1000 joinedFunding-child
    1000 Förderer Swedish Heart-Lung Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  71. 1000 joinedFunding-child
    1000 Förderer Swedish Foundation for Strategic Research |
    1000 Förderprogramm -
    1000 Fördernummer SSF; ICA08-0047
  72. 1000 joinedFunding-child
    1000 Förderer Royal Swedish Academy of Sciences |
    1000 Förderprogramm -
    1000 Fördernummer -
  73. 1000 joinedFunding-child
    1000 Förderer Swedish Diabetes Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  74. 1000 joinedFunding-child
    1000 Förderer Swedish Society of Medicine |
    1000 Förderprogramm -
    1000 Fördernummer -
  75. 1000 joinedFunding-child
    1000 Förderer Erasmus Medical Center |
    1000 Förderprogramm -
    1000 Fördernummer -
  76. 1000 joinedFunding-child
    1000 Förderer Erasmus University, Rotterdam |
    1000 Förderprogramm -
    1000 Fördernummer -
  77. 1000 joinedFunding-child
    1000 Förderer Netherlands Organization for the Health Research and Development (ZonMw) |
    1000 Förderprogramm -
    1000 Fördernummer -
  78. 1000 joinedFunding-child
    1000 Förderer Research Institute for Diseases in the Elderly (RIDE) |
    1000 Förderprogramm -
    1000 Fördernummer -
  79. 1000 joinedFunding-child
    1000 Förderer Ministry of Education, Culture and Science (Netherlands) |
    1000 Förderprogramm -
    1000 Fördernummer -
  80. 1000 joinedFunding-child
    1000 Förderer Ministry for Health, Welfare and Sports (Netherlands) |
    1000 Förderprogramm -
    1000 Fördernummer -
  81. 1000 joinedFunding-child
    1000 Förderer Municipality of Rotterdam |
    1000 Förderprogramm -
    1000 Fördernummer -
  82. 1000 joinedFunding-child
    1000 Förderer Ministry for Higher Education (Sweden) |
    1000 Förderprogramm -
    1000 Fördernummer -
  83. 1000 joinedFunding-child
    1000 Förderer GenomEUtwin |
    1000 Förderprogramm -
    1000 Fördernummer EU/QLRT-2001-01254; QLG2-CT-2002-01254
  84. 1000 joinedFunding-child
    1000 Förderer Uppsala University |
    1000 Förderprogramm -
    1000 Fördernummer -
  85. 1000 joinedFunding-child
    1000 Förderer Uppsala University Hospital |
    1000 Förderprogramm -
    1000 Fördernummer -
  86. 1000 joinedFunding-child
    1000 Förderer Social Insurance Institution of Finland, Kuopio |
    1000 Förderprogramm -
    1000 Fördernummer -
  87. 1000 joinedFunding-child
    1000 Förderer Tampere and Turku University Hospital Medical Funds |
    1000 Förderprogramm TeLeht
    1000 Fördernummer 9M048; 9N035
  88. 1000 joinedFunding-child
    1000 Förderer Paavo Nurmi Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  89. 1000 joinedFunding-child
    1000 Förderer Finnish Foundation of Cardiovascular Research (TL, OTR) |
    1000 Förderprogramm -
    1000 Fördernummer -
  90. 1000 joinedFunding-child
    1000 Förderer Finnish Cultural Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  91. 1000 joinedFunding-child
    1000 Förderer Tampere Tuberculosis Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  92. 1000 joinedFunding-child
    1000 Förderer Emil Aaltonen Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  93. 1000 joinedFunding-child
    1000 Förderer Manpei Suzuki Diabetes Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  94. 1000 joinedFunding-child
    1000 Förderer Helsinki University Doctoral Programme in Biomedicine (DPBM) |
    1000 Förderprogramm -
    1000 Fördernummer -
  95. 1000 joinedFunding-child
    1000 Förderer University of Ferrara – Holder: Prof. Guido Barbujani |
    1000 Förderprogramm -
    1000 Fördernummer -
  96. 1000 joinedFunding-child
    1000 Förderer German National Genome Research Network |
    1000 Förderprogramm NGFN-2; NGFN-plus
    1000 Fördernummer -
  97. 1000 joinedFunding-child
    1000 Förderer CARDomics |
    1000 Förderprogramm -
    1000 Fördernummer 01KU0908A
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408564.rdf
1000 Erstellt am 2018-06-27T12:45:04.414+0200
1000 Erstellt von 218
1000 beschreibt frl:6408564
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 19:01:33 CET 2020
1000 Objekt bearb. Tue Sep 04 10:29:43 CEST 2018
1000 Vgl. frl:6408564
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408564 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source