A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

  1. Huan, Tianxiao
  2. Esko, Tõnu
  3. Peters, Marjolein J.
  4. Pilling, Luke C.
  5. Schramm, Katharina
  6. Schurmann, Claudia
  7. Chen, Brian H.
  8. Liu, Chunyu
  9. Joehanes, Roby
  10. Johnson, Andrew D.
  11. Yao, Chen
  12. Ying, Sai-xia
  13. Courchesne, Paul
  14. Milani, Lili
  15. Raghavachari, Nalini
  16. Wang, Richard
  17. Liu, Poching
  18. Reinmaa, Eva
  19. Dehghan, Abbas
  20. Hofman, Albert
  21. Uitterlinden, André G.
  22. Hernandez, Dena G.
  23. Bandinelli, Stefania
  24. Singleton, Andrew
  25. Melzer, David
  26. Metspalu, Andres
  27. Carstensen, Maren
  28. Grallert, Harald
  29. Herder, Christian ORCID logo
  30. Meitinger, Thomas
  31. Peters, Annette
  32. Roden, Michael
  33. Waldenberger, Melanie
  34. Dörr, Marcus
  35. Felix, Stephan B.
  36. Zeller, Tanja
  37. International Consortium for Blood Pressure GWAS (ICBP)
  38. Vasan, Ramachandran
  39. O'Donnell, Christopher J.
  40. Munson, Peter J.
  41. Yang, Xia
  42. Prokisch, Holger
  43. Völker, Uwe
  44. van Meurs, Joyce B. J.
  45. Ferrucci, Luigi
  46. Levy, Daniel
  47. Brand, Stefan-Martin

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1000 Titel
  • A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
1000 Autor/in
  1. Huan, Tianxiao |
  2. Esko, Tõnu |
  3. Peters, Marjolein J. |
  4. Pilling, Luke C. |
  5. Schramm, Katharina |
  6. Schurmann, Claudia |
  7. Chen, Brian H. |
  8. Liu, Chunyu |
  9. Joehanes, Roby |
  10. Johnson, Andrew D. |
  11. Yao, Chen |
  12. Ying, Sai-xia |
  13. Courchesne, Paul |
  14. Milani, Lili |
  15. Raghavachari, Nalini |
  16. Wang, Richard |
  17. Liu, Poching |
  18. Reinmaa, Eva |
  19. Dehghan, Abbas |
  20. Hofman, Albert |
  21. Uitterlinden, André G. |
  22. Hernandez, Dena G. |
  23. Bandinelli, Stefania |
  24. Singleton, Andrew |
  25. Melzer, David |
  26. Metspalu, Andres |
  27. Carstensen, Maren |
  28. Grallert, Harald |
  29. Herder, Christian |
  30. Meitinger, Thomas |
  31. Peters, Annette |
  32. Roden, Michael |
  33. Waldenberger, Melanie |
  34. Dörr, Marcus |
  35. Felix, Stephan B. |
  36. Zeller, Tanja |
  37. International Consortium for Blood Pressure GWAS (ICBP) |
  38. Vasan, Ramachandran |
  39. O'Donnell, Christopher J. |
  40. Munson, Peter J. |
  41. Yang, Xia |
  42. Prokisch, Holger |
  43. Völker, Uwe |
  44. van Meurs, Joyce B. J. |
  45. Ferrucci, Luigi |
  46. Levy, Daniel |
  47. Brand, Stefan-Martin |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-03-18
1000 Erschienen in
1000 Quellenangabe
  • 11(3):e1005035
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pgen.1005035 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365001/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005035#sec018 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%–9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension.
1000 Sacherschließung
lokal Clinical genetics
lokal Medicine and health sciences
lokal Drug research and development
lokal Genome-wide association studies
lokal Gene expression
lokal Research laboratories
lokal Cardiology
lokal Genetic epidemiology
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 (Academic) Editor
1000 Label
1000 Förderer
  1. National Institutes of Health |
  2. Division of Intramural Research |
  3. National Heart, Lung, and Blood Institute |
  4. Estonian Ministry of Science and Education |
  5. University of Tartu |
  6. European Regional Development Fund |
  7. FP7 |
  8. NWO |
  9. Erasmus Medical Center |
  10. Erasmus University, Rotterdam |
  11. Netherlands Organization for the Health Research and Development (ZonMw) |
  12. Netherlands Organisation of Scientific Research NWO Investments |
  13. Research Institute for Diseases in the Elderly |
  14. Ministry of Education, Culture and Science (Netherlands) |
  15. Ministry for Health, Welfare and Sports (Netherlands) |
  16. European Commission |
  17. Municipality of Rotterdam |
  18. Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine |
  19. National Institute on Aging |
  20. Wellcome Trust |
  21. Helmholtz Zentrum München |
  22. German Research Center for Environmental Health |
  23. German Ministry of Education and Research (BMBF) |
  24. State of Bavaria (Germany) |
  25. Munich Center of Health Sciences (MC Health) |
  26. Ludwig Maximilians-Universität |
  27. German Center for Diabetes Research (DZD) |
  28. German Federal Ministry of Health |
  29. Ministry of School, Science and Research of the State of North-Rhine-Westphalia |
  30. DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung – German Centre for Cardiovascular Research) |
  31. European Commission |
  32. Ministry of Cultural Affairs |
  33. Social Ministry of the Federal State of Mecklenburg-West Pomerania |
1000 Fördernummer
  1. N01-HC-25195
  2. -
  3. -
  4. SF0180142s08
  5. SP1GVARENG
  6. 3.2.0304.11-0312
  7. 313010
  8. 916.12.154
  9. -
  10. -
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  12. 175.010.2005.011, 911-03-012
  13. 014-93-015
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  20. WT097835MF
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  31. FP7/2007-2013; HEALTH-F2-2011; 277984; HEALTH-F2-2013,; 603288
  32. -
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1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. Development Fund
  6. EXCEGEN
  7. -
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  9. -
  10. -
  11. -
  12. -
  13. RIDE2
  14. -
  15. -
  16. -
  17. -
  18. -
  19. Intramural Research Program
  20. Institutional Strategic Support Award
  21. -
  22. -
  23. National Genome Research Network NGFN plus Atherogenomics
  24. -
  25. -
  26. -
  27. -
  28. -
  29. -
  30. framework of the MetaXpress consortium
  31. Seventh Framework Programme
  32. -
  33. -
1000 Dateien
  1. A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
    A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer N01-HC-25195
  2. 1000 joinedFunding-child
    1000 Förderer Division of Intramural Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer National Heart, Lung, and Blood Institute |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Estonian Ministry of Science and Education |
    1000 Förderprogramm -
    1000 Fördernummer SF0180142s08
  5. 1000 joinedFunding-child
    1000 Förderer University of Tartu |
    1000 Förderprogramm Development Fund
    1000 Fördernummer SP1GVARENG
  6. 1000 joinedFunding-child
    1000 Förderer European Regional Development Fund |
    1000 Förderprogramm EXCEGEN
    1000 Fördernummer 3.2.0304.11-0312
  7. 1000 joinedFunding-child
    1000 Förderer FP7 |
    1000 Förderprogramm -
    1000 Fördernummer 313010
  8. 1000 joinedFunding-child
    1000 Förderer NWO |
    1000 Förderprogramm -
    1000 Fördernummer 916.12.154
  9. 1000 joinedFunding-child
    1000 Förderer Erasmus Medical Center |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Erasmus University, Rotterdam |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Netherlands Organization for the Health Research and Development (ZonMw) |
    1000 Förderprogramm -
    1000 Fördernummer -
  12. 1000 joinedFunding-child
    1000 Förderer Netherlands Organisation of Scientific Research NWO Investments |
    1000 Förderprogramm -
    1000 Fördernummer 175.010.2005.011, 911-03-012
  13. 1000 joinedFunding-child
    1000 Förderer Research Institute for Diseases in the Elderly |
    1000 Förderprogramm RIDE2
    1000 Fördernummer 014-93-015
  14. 1000 joinedFunding-child
    1000 Förderer Ministry of Education, Culture and Science (Netherlands) |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer Ministry for Health, Welfare and Sports (Netherlands) |
    1000 Förderprogramm -
    1000 Fördernummer -
  16. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer Municipality of Rotterdam |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine |
    1000 Förderprogramm -
    1000 Fördernummer -
  19. 1000 joinedFunding-child
    1000 Förderer National Institute on Aging |
    1000 Förderprogramm Intramural Research Program
    1000 Fördernummer -
  20. 1000 joinedFunding-child
    1000 Förderer Wellcome Trust |
    1000 Förderprogramm Institutional Strategic Support Award
    1000 Fördernummer WT097835MF
  21. 1000 joinedFunding-child
    1000 Förderer Helmholtz Zentrum München |
    1000 Förderprogramm -
    1000 Fördernummer -
  22. 1000 joinedFunding-child
    1000 Förderer German Research Center for Environmental Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  23. 1000 joinedFunding-child
    1000 Förderer German Ministry of Education and Research (BMBF) |
    1000 Förderprogramm National Genome Research Network NGFN plus Atherogenomics
    1000 Fördernummer 01GS0834; 01ZZ9603; 01ZZ0103; 01ZZ0403; 03IS2061A; 03ZIK012
  24. 1000 joinedFunding-child
    1000 Förderer State of Bavaria (Germany) |
    1000 Förderprogramm -
    1000 Fördernummer -
  25. 1000 joinedFunding-child
    1000 Förderer Munich Center of Health Sciences (MC Health) |
    1000 Förderprogramm -
    1000 Fördernummer -
  26. 1000 joinedFunding-child
    1000 Förderer Ludwig Maximilians-Universität |
    1000 Förderprogramm -
    1000 Fördernummer -
  27. 1000 joinedFunding-child
    1000 Förderer German Center for Diabetes Research (DZD) |
    1000 Förderprogramm -
    1000 Fördernummer -
  28. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  29. 1000 joinedFunding-child
    1000 Förderer Ministry of School, Science and Research of the State of North-Rhine-Westphalia |
    1000 Förderprogramm -
    1000 Fördernummer -
  30. 1000 joinedFunding-child
    1000 Förderer DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung – German Centre for Cardiovascular Research) |
    1000 Förderprogramm framework of the MetaXpress consortium
    1000 Fördernummer -
  31. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Seventh Framework Programme
    1000 Fördernummer FP7/2007-2013; HEALTH-F2-2011; 277984; HEALTH-F2-2013,; 603288
  32. 1000 joinedFunding-child
    1000 Förderer Ministry of Cultural Affairs |
    1000 Förderprogramm -
    1000 Fördernummer -
  33. 1000 joinedFunding-child
    1000 Förderer Social Ministry of the Federal State of Mecklenburg-West Pomerania |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6408576.rdf
1000 Erstellt am 2018-06-28T09:57:28.274+0200
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