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Polysialic Acid in Human Plasma Can Compensate the Cytotoxicity of Histones.pdf 1,93MB
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1000 Titel
  • Polysialic Acid in Human Plasma Can Compensate the Cytotoxicity of Histones
1000 Autor/in
  1. Zlatina, Kristina |
  2. Saftenberger, Marc |
  3. Kühnle, Andrea |
  4. Galuska, Christina E. |
  5. Gärtner, Ulrich |
  6. Rebl, Alexander |
  7. Oster, Michael |
  8. Vernunft, Andreas |
  9. Galuska, Sebastian P. |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-06-05
1000 Erschienen in
1000 Quellenangabe
  • 19(6):1679
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3390/ijms19061679 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032143/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The innate immune system has numerous mechanisms to fight against pathogens, including the formation of neutrophil extracellular traps (NETs). By spreading out chromatin, antimicrobial peptides and enzymes, neutrophils efficiently trap pathogens like bacteria and facilitate their elimination. During this process, high concentrations of extracellular histones can be reached. Several researchers have demonstrated that the cytotoxic characteristics of these histones can trigger diseases like sepsis. Interestingly, the carbohydrate polysialic acid (polySia) can bind histones and reduce histone-mediated cytotoxicity in a chain length-dependent manner. In the present study, we examined the chain length of polySia in plasma and tested its ability to decrease the cytotoxic characteristics of extracellular histones. Remarkably, we detected polySia not only in the soluble fraction of plasma, but also on enriched extracellular vesicles (EVs). Chain length analysis revealed that polySia chains originating from human plasma can consists of more than 40 sialic acid residues and show a cytoprotective effect against extracellular histones. Intriguingly, polySia is not only present in human plasma but also in fish and other branches of vertebrates. Thus, polySia is a physiological element in plasma and may represent a natural buffer for extracellular histones.
1000 Sacherschließung
lokal NETs
lokal neutrophil extracellular traps
lokal polysialic acid
lokal histone
lokal plasma
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-2912-3445|https://frl.publisso.de/adhoc/creator/U2FmdGVuYmVyZ2VyLCBNYXJj|https://frl.publisso.de/adhoc/creator/S8O8aG5sZSwgQW5kcmVh|https://frl.publisso.de/adhoc/creator/R2FsdXNrYSwgQ2hyaXN0aW5hIEUu|https://frl.publisso.de/adhoc/creator/R8OkcnRuZXIsIFVscmljaA==|http://orcid.org/0000-0002-2918-7433|https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/VmVybnVuZnQsIEFuZHJlYXM=|http://orcid.org/0000-0001-5565-0252
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Leibniz Association |
  3. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. GA 1755/1-2
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. Open Access Fund
  3. Open Access Fund
1000 Dateien
  1. Polysialic Acid in Human Plasma Can Compensate the Cytotoxicity of Histones
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer GA 1755/1-2
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408998.rdf
1000 Erstellt am 2018-07-24T10:14:59.345+0200
1000 Erstellt von 218
1000 beschreibt frl:6408998
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Aug 10 11:19:23 CEST 2018
1000 Objekt bearb. Fri Aug 10 11:19:05 CEST 2018
1000 Vgl. frl:6408998
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408998 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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